scholarly journals Probing mouse brain microstructure using oscillating gradient diffusion MRI

2011 ◽  
Vol 67 (1) ◽  
pp. 98-109 ◽  
Author(s):  
Manisha Aggarwal ◽  
Melina V. Jones ◽  
Peter A. Calabresi ◽  
Susumu Mori ◽  
Jiangyang Zhang
Keyword(s):  
Mouse Brain ◽  
Diffusion Mri ◽  
Gradient Diffusion ◽  
Brain Microstructure

scholarly journals Feasibility of oscillating and pulsed gradient diffusion MRI to assess neonatal hypoxia-ischemia on clinical systems

2020 ◽  
pp. 0271678X2094435 ◽  
Author(s):  
Fusheng Gao ◽  
Xiaoxia Shen ◽  
Hongxi Zhang ◽  
Ruicheng Ba ◽  
Xiaolu Ma ◽  
...  
Keyword(s):  
White Matter ◽  
Diffusion Mri ◽  
High Sensitivity ◽  
B Value ◽  
Subcortical White Matter ◽  
Gradient Diffusion ◽  
Normal Term ◽  
Deep Grey Matter ◽  
The Difference ◽  
Brain Microstructure

Diffusion-time- ( td) dependent diffusion MRI (dMRI) extends our ability to characterize brain microstructure by measuring dMRI signals at varying td. The use of oscillating gradient (OG) is essential for accessing short td but is technically challenging on clinical MRI systems. This study aims to investigate the clinical feasibility and value of td-dependent dMRI in neonatal hypoxic-ischemic encephalopathy (HIE). Eighteen HIE neonates and six normal term-born neonates were scanned on a 3 T scanner, with OG-dMRI at an oscillating frequency of 33 Hz (equivalent td ≈ 7.5 ms) and pulsed gradient (PG)-dMRI at a td of 82.8 ms and b-value of 700 s/mm2. The td-dependence, as quantified by the difference in apparent diffusivity coefficients between OG- and PG-dMRI (ΔADC), was observed in the normal neonatal brains, and the ΔADC was higher in the subcortical white matter than the deep grey matter. In HIE neonates with severe and moderate injury, ΔADC significantly increased in the basal ganglia (BG) compared to the controls (23.7% and 10.6%, respectively). In contrast, the conventional PG-ADC showed a 12.6% reduction only in the severe HIE group. White matter edema regions also demonstrated increased ΔADC, where PG-ADC did not show apparent changes. Our result demonstrated that td-dependent dMRI provided high sensitivity in detecting moderate-to-severe HIE.

scholarly journals In utero localized diffusion MRI of the embryonic mouse brain microstructure and injury

2014 ◽  
Vol 42 (3) ◽  
pp. 717-728 ◽  
Author(s):  
Dan Wu ◽  
Jun Lei ◽  
Jason M. Rosenzweig ◽  
Irina Burd ◽  
Jiangyang Zhang
Keyword(s):  
Mouse Brain ◽  
Diffusion Mri ◽  
In Utero ◽  
Embryonic Mouse ◽  
Brain Microstructure

Registration of a 3D mouse brain atlas with brain microstructure data

2003 ◽  
Vol 52-54 ◽  
pp. 307-312 ◽  
Author(s):  
Wonryull Koh ◽  
Bruce H. McCormick
Keyword(s):  
Mouse Brain ◽  
Brain Atlas ◽  
Brain Microstructure

scholarly journals Imaging neurodegeneration in the mouse hippocampus after neonatal hypoxia-ischemia using oscillating gradient diffusion MRI

2013 ◽  
Vol 72 (3) ◽  
pp. 829-840 ◽  
Author(s):  
Manisha Aggarwal ◽  
Jennifer Burnsed ◽  
Lee J. Martin ◽  
Frances J. Northington ◽  
Jiangyang Zhang
Keyword(s):  
Diffusion Mri ◽  
Neonatal Hypoxia ◽  
Gradient Diffusion ◽  
Hypoxia Ischemia ◽  
Mouse Hippocampus

scholarly journals Neurite orientation dispersion and density imaging of mouse brain microstructure

2019 ◽  
Vol 224 (5) ◽  
pp. 1797-1813 ◽  
Author(s):  
Nian Wang ◽  
Jieying Zhang ◽  
Gary Cofer ◽  
Yi Qi ◽  
Robert J. Anderson ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Brain Microstructure

scholarly journals Early detection of human glioma sphere xenografts in mouse brain using diffusion MRI at 14.1 T

2016 ◽  
Vol 29 (11) ◽  
pp. 1577-1589 ◽  
Author(s):  
P. Porcari ◽  
M. E. Hegi ◽  
H. Lei ◽  
M-F. Hamou ◽  
I. Vassallo ◽  
...  
Keyword(s):  
Early Detection ◽  
Mouse Brain ◽  
Diffusion Mri ◽  
Human Glioma

Characterizing glioma microenvironment with ultra-high gradient diffusion MRI.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 2050-2050
Author(s):  
Ina Ly ◽  
Barbara Wichtmann ◽  
Susie Yi Huang ◽  
Aapo Nummenmaa ◽  
Ovidiu Andronesi ◽  
...  
Keyword(s):  
Diffusion Model ◽  
Diffusion Mri ◽  
Volume Fraction ◽  
Response To Treatment ◽  
Imaging Biomarker ◽  
Normal Brain ◽  
Post Contrast ◽  
Major Barrier ◽  
High Gradient ◽  
Gradient Diffusion

2050 Background: The infiltrating nature of gliomas, particularly into the peritumoral area, is a major barrier to improving clinical outcome as microscopic disease remains even after apparent gross total resection. Conventional T1 post-contrast and T2/FLAIR MRI do not capture full tumor extent. A better imaging biomarker is needed to improve differentiation between tumor, peritumoral area and normal brain. Methods: 4 pre-surgical patients with non-enhancing, FLAIR-hyperintense lesions suspicious for glioma underwent ultra-high gradient diffusion MRI on the Connectome MRI scanner, a unique scanner with maximum gradient strength of 300 mT/m enabling mapping of cellular microstructures on a micron-level scale. The FLAIR area was defined as the tumor region of interest (ROI). Radiographically normal appearing brain up to 1 cm around the FLAIR area was defined as the peritumoral ROI. Using a novel 3 compartment diffusion model (Linear Multiscale Model), the volume fraction of water (VFW) was calculated within restricted (intracellular), hindered (extracellular) and free (CSF) spaces. VFW in the tumor, peritumoral ROI, contralateral normal white matter (WM) and cortex were compared. Results: Within the tumor ROI, the median VFW in the restricted compartment was decreased vs. the peritumoral ROI (↓ 34%), WM (↓ 46%) and cortex (↓ 18%) while median VFW in the hindered compartment was increased vs. the peritumoral ROI (↑ 26%), WM (↑ 54%) and cortex (↑ 25%). Within the peritumoral ROI, median VFW in the hindered compartment was increased compared to WM (↑ 23%). 3 patients had available histopathology revealing isocitrate dehydrogenase-mutant gliomas. Conclusions: Using ultra-high gradient diffusion MRI and a novel diffusion model, we detected distinct diffusion patterns in the tumor and peritumoral area not seen on conventional MRI. Lower VFW in the restricted compartment within the tumor may reflect decreased intracellular water mobility due to enlarged nuclei. Higher VFW in the hindered compartment in the tumor and peritumoral area may reflect higher degree of tissue permeability and edema. MRI-pathology and larger cohort validation studies are underway to elucidate microenvironment changes in response to treatment.

scholarly journals Oscillating gradient diffusion MRI reveals unique microstructural information in normal and hypoxia-ischemia injured mouse brains

2014 ◽  
Vol 72 (5) ◽  
pp. 1366-1374 ◽  
Author(s):  
Dan Wu ◽  
Lee J. Martin ◽  
Frances J. Northington ◽  
Jiangyang Zhang
Keyword(s):  
Diffusion Mri ◽  
Gradient Diffusion ◽  
Hypoxia Ischemia

scholarly journals Improved fidelity of brain microstructure mapping from single-shell diffusion MRI

2015 ◽  
Vol 26 (1) ◽  
pp. 268-286 ◽  
Author(s):  
Maxime Taquet ◽  
Benoit Scherrer ◽  
Nicolas Boumal ◽  
Jurriaan M. Peters ◽  
Benoit Macq ◽  
...  
Keyword(s):  
Diffusion Mri ◽  
Brain Microstructure ◽  
Single Shell

Measurements of brain microstructure and connectivity with diffusion MRI

2011 ◽  
Vol 2 (Supplement A) ◽  
pp. A99-A102
Author(s):  
Chun-Yi Zac Lo ◽  
Yong He ◽  
Ching-Po Lin
Keyword(s):  
Diffusion Mri ◽  
Brain Microstructure
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