Hyperpolarized 13 C NMR studies of glucose metabolism in living breast cancer cell cultures

2013 ◽  
Vol 26 (12) ◽  
pp. 1831-1843 ◽  
Author(s):  
T. Harris ◽  
H. Degani ◽  
L. Frydman
Keyword(s):  
Breast Cancer ◽  
Glucose Metabolism ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cell Cultures ◽  
Nmr Studies ◽  
C Nmr

scholarly journals EGF receptor stimulation shifts breast cancer cell glucose metabolism toward glycolytic flux through PI3 kinase signaling

PLoS ONE ◽  
2019 ◽  
Vol 14 (9) ◽  
pp. e0221294 ◽  
Author(s):  
Kyung-Ho Jung ◽  
Eun Jeong Lee ◽  
Jin Won Park ◽  
Jin Hee Lee ◽  
Seung Hwan Moon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Glucose Metabolism ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Egf Receptor ◽  
Pi3 Kinase ◽  
Glycolytic Flux ◽  
Kinase Signaling ◽  
Receptor Stimulation ◽  
Cell Glucose

scholarly journals Resveratrol decreases breast cancer cell viability and glucose metabolism by inhibiting 6-phosphofructo-1-kinase

Biochimie ◽  
2013 ◽  
Vol 95 (6) ◽  
pp. 1336-1343 ◽  
Author(s):  
Lilian S. Gomez ◽  
Patricia Zancan ◽  
Mariah C. Marcondes ◽  
Livia Ramos-Santos ◽  
José Roberto Meyer-Fernandes ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Glucose Metabolism ◽  
Cell Viability ◽  
Cancer Cell ◽  
Breast Cancer Cell

Abstract 244: Eicosapentaenoic acid reduces effects of some adipocyte derived factors on breast cancer cell inflammation and glucose metabolism

2017 ◽  
Author(s):  
Arwa Aljawadi ◽  
Sara Alhaj ◽  
Suranganie Dharamawardhane ◽  
Shane Scoggin ◽  
Lauren Gollahon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Glucose Metabolism ◽  
Eicosapentaenoic Acid ◽  
Cancer Cell ◽  
Breast Cancer Cell

scholarly journals Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models

2018 ◽  
Vol 9 (11) ◽  
pp. 5682-5696 ◽  
Author(s):  
Ran Wei ◽  
Limin Mao ◽  
Ping Xu ◽  
Xinghai Zheng ◽  
Robert M. Hackman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Glucose Metabolism ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Growth ◽  
Preclinical Models ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Breast Cancer Growth

EGCG reduces breast cancer growth through the inhibition of key enzymes that participate in the glycolytic pathway and the suppression of glucose metabolism.

scholarly journals Extracellular vesicles induce aggressive phenotype of luminal breast cancer cells by PKM2 phosphorylation

2021 ◽  
Author(s):  
Seo Young Kang ◽  
Eun Ji Lee ◽  
Jung Woo Byun ◽  
Dohyun Han ◽  
Yoori Choi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Glucose Metabolism ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Extracellular Vesicles ◽  
Aerobic Glycolysis ◽  
Serine Phosphorylation ◽  
Mcf7 Cells ◽  
Glycolytic Activity

AbstractThe aerobic glycolysis is a hallmark of cancer glucose metabolism. Several studies have suggested that cancer-derived extracellular vesicles (EVs) can modulate glucose metabolism in adjacent cells and promote disease progression. Here we suggest that EVs originated from cancer cell with highly glycolytic activity can modulate glucose metabolism in the recipient cancer cells with relative low glycolytic activity, and further induce cell proliferation. Two types of breast cancer cell lines with different levels of glycolytic activity, MDA-MB-231 of a claudin low-type breast cancer cell and MCF7 of luminal type breast cancer cell, were selected and co-cultured using indirect co-culture system such as transwell system or microfluidic system. Glucose uptake of the recipient MCF7 cells was markedly increased after co-culture with MDA-MB-231 cells. MCF7 cells after co-culture with MDA-MB-231-tdTomato cells represented multiple tdTomato signal inside the cell, which proved that EVs originated from MDA-MB-231-tdTomato were transferred to MCF7 cell. In addition, serine phosphorylation of PKM2 necessary for tumorigenesis was highly activated, and tyrosine phosphorylation of PKM2 suggesting activated aerobic glycolysis was also increased in the co-cultured MCF7 cells. Proteomic profiling of the co-cultured MCF7 cells revealed the proliferation and dedifferentiation of MCF7 cells, and further confirmed epithelial-mesenchymal transition (EMT), which is a key phenomenon for cancer metastasis. In the transcriptomic analysis, glycolysis increased in co-cultured MCF7 cells, and the component analysis of genes associated with glycolysis revealed that the next major component after cytoplasm was extracellular exosome. Proteomic analysis of EVs revealed that there were important proteins in the EV such as EGFR, ERBB2 and MAPK for phosphorylating PKM2. This phenomenon suggests the potential for aggressive cancer cells to affect other cancer cells through EV mediators.

Melatonin and vitamin D 3 increase TGF-β 1 release and induce growth inhibition in breast cancer cell cultures

2003 ◽  
Vol 110 (2) ◽  
pp. 332-337 ◽  
Author(s):  
Mariano Bizzarri ◽  
Alessandra Cucina ◽  
Maria Giovanna Valente ◽  
Fausto Tagliaferri ◽  
Valeria Borrelli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Growth Inhibition ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cell Cultures ◽  
Vitamin D 3 ◽  
Induce Growth Inhibition
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