In vivo MRI analysis of depth-dependent ultrastructure in human knee cartilage at 7 T

2013 ◽  
Vol 26 (11) ◽  
pp. 1412-1419 ◽  
Author(s):  
Nikita Garnov ◽  
Wilfried Gründer ◽  
Gregor Thörmer ◽  
Robert Trampel ◽  
Robert Turner ◽  
...  
Keyword(s):  
2018 ◽  
Vol 28 (8) ◽  
pp. 3384-3392 ◽  
Author(s):  
Alexander Kolb ◽  
Simon Robinson ◽  
David Stelzeneder ◽  
Markus Schreiner ◽  
Catharina Chiari ◽  
...  

2010 ◽  
Vol 18 ◽  
pp. S182-S183
Author(s):  
Z.K. Hawezi ◽  
C.J. Tiderius ◽  
J. Svensson ◽  
L.E. Dahlberg ◽  
E. Lammentausta
Keyword(s):  

2011 ◽  
Vol 19 ◽  
pp. S177
Author(s):  
M. Haris ◽  
A. Singh ◽  
V. Kassey ◽  
K. Cai ◽  
D. Reddy ◽  
...  
Keyword(s):  

2011 ◽  
Vol 34 (6) ◽  
pp. 1352-1358 ◽  
Author(s):  
Zana K. Hawezi ◽  
Eveliina Lammentausta ◽  
Jonas Svensson ◽  
Leif E. Dahlberg ◽  
Carl J. Tiderius
Keyword(s):  

2013 ◽  
Vol 32 (3) ◽  
pp. 403-412 ◽  
Author(s):  
Harri T. Kokkonen ◽  
Juha-Sampo Suomalainen ◽  
Antti Joukainen ◽  
Heikki Kröger ◽  
Joonas Sirola ◽  
...  

2021 ◽  
Vol 22 (8) ◽  
pp. 3844
Author(s):  
Jacques Hernigou ◽  
Pascale Vertongen ◽  
Joanne Rasschaert ◽  
Philippe Hernigou

The value of bone marrow aspirate concentrates for treatment of human knee cartilage lesions is unclear. Most of the studies were performed with intra-articular injections. However, subchondral bone plays an important role in the progression of osteoarthritis. We investigated by a literature review whether joint, subchondral bone, or/and scaffolds implantation of fresh autologous bone marrow aspirate concentrated (BMAC) containing mesenchymal stem cells (MSCs) would improve osteoarthritis (OA). There is in vivo evidence that suggests that all these different approaches (intra-articular injections, subchondral implantation, scaffolds loaded with BMAC) can improve the patient. This review analyzes the evidence for each different approach to treat OA. We found that the use of intra-articular injections resulted in a significant relief of pain symptoms in the short term and was maintained in 12 months. However, the clinical trials indicate that the application of autologous bone marrow concentrates in combination with scaffolds or in injection in the subchondral bone was superior to intra-articular injection for long-term results. The tendency of MSCs to differentiate into fibrocartilage affecting the outcome was a common issue faced by all the studies when biopsies were performed, except for scaffolds implantation in which some hyaline cartilage was found. The review suggests also that both implantation of subchondral BMAC and scaffolds loaded with BMAC could reduce the need for further surgery.


2016 ◽  
Vol 77 (5) ◽  
pp. 1866-1873 ◽  
Author(s):  
Guruprasad Krishnamoorthy ◽  
Ravi Prakash Reddy Nanga ◽  
Puneet Bagga ◽  
Hari Hariharan ◽  
Ravinder Reddy

2014 ◽  
Vol 40 (9) ◽  
pp. 2039-2047 ◽  
Author(s):  
Jukka Liukkonen ◽  
Petri Lehenkari ◽  
Jukka Hirvasniemi ◽  
Antti Joukainen ◽  
Tuomas Virén ◽  
...  

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