scholarly journals Assessment of glycosaminoglycan concentration changes in the intervertebral disc via chemical exchange saturation transfer

2011 ◽  
Vol 25 (2) ◽  
pp. 255-261 ◽  
Author(s):  
Galit Saar ◽  
Boyang Zhang ◽  
Wen Ling ◽  
Ravinder R. Regatte ◽  
Gil Navon ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Concentration Changes

scholarly journals Presaturation Power Adjusted Pulsed CEST: A Method to Increase Independence of Target CEST Signals

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Kazufumi Kikuchi ◽  
Keisuke Ishimatsu ◽  
Shanrong Zhang ◽  
Ivan E. Dimitrov ◽  
Hiroshi Honda ◽  
...  
Keyword(s):  
Exchange Rates ◽  
Chemical Exchange ◽  
Renal Medulla ◽  
Chemical Exchange Saturation Transfer ◽  
Amide Proton ◽  
Saturation Transfer ◽  
Cest Imaging ◽  
Concentration Changes

Chemical exchange saturation transfer (CEST) imaging has been demonstrated to discuss the concentration changes of amide proton, glutamate, creatine, or glucose measured at 3.5, 3.0, 2.0, and 1.0–1.2 ppm. However, these peaks in z-spectra are quite broad and overlap with each other, and thus, the independence of a CEST signal on any specific metabolite is still open to question. Here, we described whether there was interference among the CEST signals and how these CEST signals behave when the power of the presaturation pulse was changed. Based on these results, further experiments were designed to investigate a method to increase the independence of the CEST signal in both phantoms and animals. The result illustrates a clear interference among CEST signals. A presaturation power adjusted pulsed- (PPAP-) CEST method which was designed based on the exchange rates of the metabolites can be used to remove contributions from other exchanging species in the same sample. Further, the method was shown to improve the independence of the glutamate signal in vivo in the renal medulla in mice. The PPAP-CEST method has the potential to increase the independence of any target CEST signals in vivo by choosing the appropriate combination of pulse amplitudes and durations.

scholarly journals Evaluating Lumbar Intervertebral Disc Degeneration on a Compositional Level Using Chemical Exchange Saturation Transfer: Preliminary Results in Patients with Adolescent Idiopathic Scoliosis

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 934
Author(s):  
Lena M. Wollschläger ◽  
Sven Nebelung ◽  
Christoph Schleich ◽  
Anja Müller-Lutz ◽  
Karl L. Radke ◽  
...  
Keyword(s):  
Adolescent Idiopathic Scoliosis ◽  
Intervertebral Disc ◽  
Idiopathic Scoliosis ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Healthy Controls ◽  
Saturation Transfer ◽  
Scoliotic Curve ◽  
Lumbar Intervertebral Disc ◽  
Ivd Degeneration

Lumbar intervertebral disc (IVD) degeneration is characterized by structural and compositional changes. This study aimed to assess the glycosaminoglycan (GAG) content of IVDs of patients with adolescent idiopathic scoliosis (AIS) and healthy controls using GAG chemical exchange saturation transfer (gagCEST) imaging. Ten AIS patients (mean age 18.3 ± 8.2 years) and 16 healthy controls (mean age 25.5 ± 1.7 years) were included. Clinical standard morphologic MR images (T1w-, T2w-, and STIR-sequences), to rule out further spinal disorders and assess IVD degeneration using the Pfirrmann score, and compositional gagCEST sequences were acquired on a 3T MRI. In AIS patients, the most distal scoliotic curve was determined on whole-spine conventional radiographs and morphological MRI and IVDs were divided as to whether they were affected by scoliotic deformity, i.e., proximal (affected, aIVDs) or distal (unaffected, uaIVDs) to the stable vertebra of the most distal scoliotic curve. Linear mixed models were used to compare mean gagCEST-values. Over all segments, AIS-patients’ IVDs exhibited significantly lower gagCEST-values than the controls: 2.76 [2.32, 3.20]% (AIS), 3.51 [3.16, 3.86]% (Control); p = 0.005. Meanwhile, no significant differences were found for gagCEST values comparing aIVDs with uaIVDs. In conclusion, as a powerful diagnostic adjunct, gagCEST imaging may be prospectively applied to detect early compositional degenerative changes in patients suffering from AIS.

scholarly journals Quantitative chemical exchange saturation transfer MRI of intervertebral disc in a porcine model

2016 ◽  
Vol 76 (6) ◽  
pp. 1677-1683 ◽  
Author(s):  
Zhengwei Zhou ◽  
Maxim Bez ◽  
Wafa Tawackoli ◽  
Joseph Giaconi ◽  
Dmitriy Sheyn ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Porcine Model ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Quantitative Chemical
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