scholarly journals Ex vivo porcine model to measure pH dependence of chemical exchange saturation transfer effect of glycosaminoglycan in the intervertebral disc

2013 ◽  
Vol 71 (5) ◽  
pp. 1743-1749 ◽  
Author(s):  
Gerd Melkus ◽  
Michelle Grabau ◽  
Dimitrios C. Karampinos ◽  
Sharmila Majumdar
Keyword(s):  
Intervertebral Disc ◽  
Porcine Model ◽  
Chemical Exchange ◽  
Ex Vivo ◽  
Ph Dependence ◽  
Transfer Effect ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer

scholarly journals Quantitative chemical exchange saturation transfer MRI of intervertebral disc in a porcine model

2016 ◽  
Vol 76 (6) ◽  
pp. 1677-1683 ◽  
Author(s):  
Zhengwei Zhou ◽  
Maxim Bez ◽  
Wafa Tawackoli ◽  
Joseph Giaconi ◽  
Dmitriy Sheyn ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Porcine Model ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Quantitative Chemical

scholarly journals Assessment of glycosaminoglycan concentration changes in the intervertebral disc via chemical exchange saturation transfer

2011 ◽  
Vol 25 (2) ◽  
pp. 255-261 ◽  
Author(s):  
Galit Saar ◽  
Boyang Zhang ◽  
Wen Ling ◽  
Ravinder R. Regatte ◽  
Gil Navon ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Concentration Changes

scholarly journals Evaluating Lumbar Intervertebral Disc Degeneration on a Compositional Level Using Chemical Exchange Saturation Transfer: Preliminary Results in Patients with Adolescent Idiopathic Scoliosis

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 934
Author(s):  
Lena M. Wollschläger ◽  
Sven Nebelung ◽  
Christoph Schleich ◽  
Anja Müller-Lutz ◽  
Karl L. Radke ◽  
...  
Keyword(s):  
Adolescent Idiopathic Scoliosis ◽  
Intervertebral Disc ◽  
Idiopathic Scoliosis ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Healthy Controls ◽  
Saturation Transfer ◽  
Scoliotic Curve ◽  
Lumbar Intervertebral Disc ◽  
Ivd Degeneration

Lumbar intervertebral disc (IVD) degeneration is characterized by structural and compositional changes. This study aimed to assess the glycosaminoglycan (GAG) content of IVDs of patients with adolescent idiopathic scoliosis (AIS) and healthy controls using GAG chemical exchange saturation transfer (gagCEST) imaging. Ten AIS patients (mean age 18.3 ± 8.2 years) and 16 healthy controls (mean age 25.5 ± 1.7 years) were included. Clinical standard morphologic MR images (T1w-, T2w-, and STIR-sequences), to rule out further spinal disorders and assess IVD degeneration using the Pfirrmann score, and compositional gagCEST sequences were acquired on a 3T MRI. In AIS patients, the most distal scoliotic curve was determined on whole-spine conventional radiographs and morphological MRI and IVDs were divided as to whether they were affected by scoliotic deformity, i.e., proximal (affected, aIVDs) or distal (unaffected, uaIVDs) to the stable vertebra of the most distal scoliotic curve. Linear mixed models were used to compare mean gagCEST-values. Over all segments, AIS-patients’ IVDs exhibited significantly lower gagCEST-values than the controls: 2.76 [2.32, 3.20]% (AIS), 3.51 [3.16, 3.86]% (Control); p = 0.005. Meanwhile, no significant differences were found for gagCEST values comparing aIVDs with uaIVDs. In conclusion, as a powerful diagnostic adjunct, gagCEST imaging may be prospectively applied to detect early compositional degenerative changes in patients suffering from AIS.

Chemical exchange saturation transfer effect in blood

2013 ◽  
Vol 71 (3) ◽  
pp. 1082-1092 ◽  
Author(s):  
Shaokuan Zheng ◽  
Imramsjah M. J. van der Bom ◽  
Zhongliang Zu ◽  
Guoxing Lin ◽  
Yansong Zhao ◽  
...  
Keyword(s):  
Chemical Exchange ◽  
Transfer Effect ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer
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