scholarly journals Assessment of multiparametric MRI in a human glioma model to monitor cytotoxic and anti-angiogenic drug effects

2010 ◽  
Vol 24 (5) ◽  
pp. 473-482 ◽  
Author(s):  
Benjamin Lemasson ◽  
Thomas Christen ◽  
Xavier Tizon ◽  
Régine Farion ◽  
Nadège Fondraz ◽  
...  
Keyword(s):  
Drug Effects ◽  
Multiparametric Mri ◽  
Human Glioma ◽  
Glioma Model

766 Nuclear Factor κB Blockade by Mutant IkBa Potentiates Chemotherapeutic Efficacy in an in Vivo Human Glioma Model

Neurosurgery ◽  
2001 ◽  
Vol 49 (2) ◽  
pp. 526-526
Author(s):  
Kyle D. Weaver ◽  
Wesley Fowler ◽  
Susan Yeyeodu ◽  
Matthew Ewend
Keyword(s):  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Human Glioma ◽  
Chemotherapeutic Efficacy ◽  
Glioma Model

Cellular multiparametric MRI of neural stem cell therapy in a rat glioma model

NeuroImage ◽  
2007 ◽  
Vol 37 (3) ◽  
pp. 769-782 ◽  
Author(s):  
C. Brekke ◽  
S.C. Williams ◽  
J. Price ◽  
F. Thorsen ◽  
M. Modo
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Neural Stem Cell ◽  
Stem Cell Therapy ◽  
Multiparametric Mri ◽  
Rat Glioma ◽  
Glioma Model

scholarly journals Treatment efficacy of DNA lipid nanocapsules and DNA multimodular systems after systemic administration in a human glioma model

2012 ◽  
Vol 14 (12) ◽  
pp. 769-775 ◽  
Author(s):  
Stephanie David ◽  
Tristan Montier ◽  
Nathalie Carmoy ◽  
Pauline Resnier ◽  
Anne Clavreul ◽  
...  
Keyword(s):  
Treatment Efficacy ◽  
Systemic Administration ◽  
Human Glioma ◽  
Lipid Nanocapsules ◽  
Glioma Model

scholarly journals MR Signal Amplification for Imaging of the Mutant EGF Receptor in Orthotopic Human Glioma Model

2013 ◽  
Vol 15 (6) ◽  
pp. 675-684
Author(s):  
Mohammed Salman Shazeeb ◽  
Suresh Gupta ◽  
Alexei Bogdanov
Keyword(s):  
Signal Amplification ◽  
Egf Receptor ◽  
Human Glioma ◽  
Glioma Model

scholarly journals VEGF induces angiogenesis in a zebrafish embryo glioma model established by transplantation of human glioma cells

2012 ◽  
Vol 28 (3) ◽  
pp. 937-942 ◽  
Author(s):  
DONG LI ◽  
XIANG-PEN LI ◽  
HONG-XUAN WANG ◽  
QING-YU SHEN ◽  
XIANG-PING LI ◽  
...  
Keyword(s):  
Zebrafish Embryo ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Glioma Model

In vivo MR tracking of therapeutic microglia to a human glioma model

2011 ◽  
Vol 24 (10) ◽  
pp. 1361-1368 ◽  
Author(s):  
Emeline J. Ribot ◽  
Sylvain Miraux ◽  
Jan P. Konsman ◽  
Véronique Bouchaud ◽  
Line Pourtau ◽  
...  
Keyword(s):  
Human Glioma ◽  
Glioma Model

Reduction in Pain Sensitivity from Pharmacological Elevation of Blood Pressure in Persons with Chronically Low Blood Pressure

2009 ◽  
Vol 23 (3) ◽  
pp. 104-112 ◽  
Author(s):  
Stefan Duschek ◽  
Heike Heiss ◽  
Boriana Buechner ◽  
Rainer Schandry
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Pain Sensitivity ◽  
Pain Threshold ◽  
Pain Perception ◽  
Drug Effects ◽  
Pressure Effects ◽  
Double Blind ◽  
Low Blood Pressure ◽  
Present Trial

Recent studies have revealed evidence for increased pain sensitivity in individuals with chronically low blood pressure. The present trial explored whether pain sensitivity can be reduced by pharmacological elevation of blood pressure. Effects of the sympathomimetic midodrine on threshold and tolerance to heat pain were examined in 52 hypotensive persons (mean blood pressure 96/61 mmHg) based on a randomized, placebo-controlled, double-blind design. Heat stimuli were applied to the forearm via a contact thermode. Confounding of drug effects on pain perception with changes in skin temperature, temperature sensitivity, and mood were statistically controlled for. Compared to placebo, higher pain threshold and tolerance, increased blood pressure, as well as reduced heart rate were observed under the sympathomimetic condition. Increases in systolic blood pressure between points of measurement correlated positively with increases in pain threshold and tolerance, and decreases in heart rate were associated with increases in pain threshold. The findings underline the causal role of hypotension in the augmented pain sensitivity related to this condition. Pain reduction as a function of heart rate decrease suggests involvement of a baroreceptor-related mechanism in the pain attrition. The increased proneness of persons with chronic hypotension toward clinical pain is discussed.

An Integrative Approach to Modeling Drug Effects

1993 ◽  
Vol 38 (2) ◽  
pp. 158-158
Author(s):  
George V. Rebec
Keyword(s):  
Drug Effects ◽  
Integrative Approach
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