Real world use of oral treatments in interstitial cystitis/bladder pain syndrome in the UK: Outcome of a cross sectional study

Author(s):  
Kamaluddeen Garba ◽  
Miriam Avery ◽  
Muhammadbukhoree Yusuh ◽  
Omar Abdelwahab ◽  
Scott Harris ◽  
...  
2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Katherine A. Volpe ◽  
Rachel Mandelbaum ◽  
Larissa V. Rodriguez ◽  
Begüm Z. Özel ◽  
Renee Rolston ◽  
...  

2016 ◽  
Vol 10 (11-12) ◽  
pp. 383 ◽  
Author(s):  
Dean A. Tripp ◽  
J. Curtis Nickel ◽  
Adrijana Krsmanovic ◽  
Michel Pontari ◽  
Robert Moldwin ◽  
...  

Introduction: We sought to evaluate psychosocial factors as predictors of suicidal ideation (SI) in a tertiary care outpatient sample of women suffering from interstitial cystitis/bladder pain syndrome(IC/BPS).Methods: The patients are women managed at tertiary care centres (n=190). Controls were recruited from the community (n=117). Both groups completed questionnaires on demographics, pain (McGill Pain Questionnaire), IC/BPS symptoms, and psychological variables. Univariate and multivariate hierarchical regression modelling was conducted to examine the strength of associations and unique effects of psychosocial variables on patient SI.Results: Compared to 6% in healthy controls, 23% of patients endorsed SI in the past two weeks. Correlations between SI, depression, and catastrophizing across controls and cases show that forcontrols, SI is associated with greater pain (0.31; p<0.01) and depression only (0.59; p<0.01). For tertiary care centre cases, SI is associated with pain (0.24; p<0.01), depression (0.64; p<0.01), and catastrophizing (0.35; p<0.01). Regression analyses indicated that psychosocial variables accounted for a significant amount of variance over and above IC/BPS symptoms. Catastrophizing (i.e., helplessness) about pain and depression were significant univariate predictors of SI, but only depression predicted SI in multivariable analyses.Conclusions: Limitations of this study include its cross-sectional design and primarily correlation-based statistics. The present study is the first to implicate multiple psychosocial risk factors over and above IC/BPS-specific symptoms and patient pain experience in SI in women with IC/BPS. Depression in particular is uniquely important in predicting suicidality. These results support a multidisciplinary,proactive approach to IC/BPS involving not only treatment of disease symptoms, but also early detection/treatment of associated psychosocial problems.


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