scholarly journals S-Nitrosoglutathione protects the spinal bladder: Novel therapeutic approach to post-spinal cord injury bladder remodeling

2014 ◽  
Vol 34 (6) ◽  
pp. 519-526 ◽  
Author(s):  
Anandakumar Shunmugavel ◽  
Mushfiquddin Khan ◽  
Francis M. Hughes ◽  
J. Todd Purves ◽  
Avtar Singh ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Therapeutic Approach ◽  
Cord Injury ◽  
Novel Therapeutic

Inhibition of IL-6 signaling: A novel therapeutic approach to treating spinal cord injury pain

Pain ◽  
2013 ◽  
Vol 154 (7) ◽  
pp. 1115-1128 ◽  
Author(s):  
Jutatip Guptarak ◽  
Sheshali Wanchoo ◽  
Julieann Durham-Lee ◽  
Yewen Wu ◽  
Dragoslava Zivadinovic ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Therapeutic Approach ◽  
Cord Injury ◽  
Spinal Cord Injury Pain ◽  
Novel Therapeutic

scholarly journals Cytosolic phospholipase A 2 protein as a novel therapeutic target for spinal cord injury

2014 ◽  
Vol 75 (5) ◽  
pp. 644-658 ◽  
Author(s):  
Nai‐Kui Liu ◽  
Ling‐Xiao Deng ◽  
Yi Ping Zhang ◽  
Qing‐Bo Lu ◽  
Xiao‐Fei Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Therapeutic Target ◽  
Phospholipase A ◽  
Cytosolic Phospholipase ◽  
Cord Injury ◽  
Novel Therapeutic ◽  
Phospholipase A 2

scholarly journals MicroRNA-146a Contributes to SCI Recovery via Regulating TRAF6 and IRAK1 Expression

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Jinsong Wei ◽  
Jiafeng Wang ◽  
Yulan Zhou ◽  
Shouquan Yan ◽  
Keshen Li ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Rat Model ◽  
Proinflammatory Cytokine ◽  
Target Genes ◽  
Sham Group ◽  
Luciferase Assay ◽  
Tight Control ◽  
Cord Injury ◽  
Novel Therapeutic

MicroRNA-146a participates in spinal cord injury (SCI) recovery. Until recently, how miRNA-146a participates in SCI remained unclear. In this study, we tried to explore the roles of miRNA-146a in the recovery of SCI using a rat model. The expression of the probable target genes of miRNA-146a (including IRAK1 and TARF6) as well as proinflammation cytokines were measured until 7 days after surgery in the three groups (sham group, SCI group, and miRNA-146a antagomir injection group). Also, the animals’ motivations were estimated using Basso Beattie Bresnahan (BBB) during the whole experiment. A luciferase assay was performed to demonstrate that miRNA-146a could directly target the mRNAs of IRAK1 and TRAF6. Our experiments indicate that miRNA-146a inhibits proinflammatory cytokine secretion by suppressing IRAK1 and TRAF6 expression in the SCI model. In contrast, miRNA-146a may be upregulated by inflammatory mediators via the IRAK1/TRAF6 pathway in the spinal cord. As a negative feedback element, miRNA-146a could make sure that the expression of IRAK1- and TRAF6-mediated genes was under tight control. Thus, miRNA-146a may serve as a novel therapeutic target for SCI interventions.

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