Differential involvement of myelinated and unmyelinated nerve fibers in painful diabetic polyneuropathy

2020 ◽  
Vol 63 (1) ◽  
pp. 68-74 ◽  
Author(s):  
Eleonora Galosi ◽  
Giuseppe Di Pietro ◽  
Silvia La Cesa ◽  
Giulia Di Stefano ◽  
Caterina Leone ◽  
...  
Keyword(s):  
Diabetic Polyneuropathy ◽  
Nerve Fibers ◽  
Unmyelinated Nerve ◽  
Differential Involvement

Local Anesthetics Selectively Damage Schwann Cells of Unmyelinated Nerve Fibers

1987 ◽  
Vol 67 (3) ◽  
pp. A276-A276
Author(s):  
Robert R. Myers ◽  
Michael W. Kalichman ◽  
Henry C. Powell
Keyword(s):  
Schwann Cells ◽  
Local Anesthetics ◽  
Nerve Fibers ◽  
Unmyelinated Nerve

Conduction velocity in unmyelinated nerve fibers of a cutaneous nerve

1973 ◽  
Vol 76 (3) ◽  
pp. 1004-1007 ◽  
Author(s):  
A. V. Zeveke ◽  
V. I. Myaderov ◽  
V. A. Utkin ◽  
V. L. Shaposhnikov
Keyword(s):  
Conduction Velocity ◽  
Nerve Fibers ◽  
Cutaneous Nerve ◽  
Unmyelinated Nerve

Nerve Fiber Synapses on Spiral Ganglion Cells in the Human Cochlea

1979 ◽  
Vol 88 (6_suppl2) ◽  
pp. 1-17 ◽  
Author(s):  
Robert S. Kimura ◽  
Carol Y. Ota ◽  
Tadahiko Takahashi
Keyword(s):  
Nerve Fiber ◽  
Ganglion Cells ◽  
Spiral Ganglion ◽  
Nerve Fibers ◽  
Parasympathetic Nerve ◽  
Human Cochlea ◽  
Cell Processes ◽  
Unmyelinated Nerve ◽  
Axodendritic Synapses ◽  
Axosomatic Synapses

Nerve fiber synapses were observed on the small myelinated and unmyelinated spiral ganglion cells of the human cochlea. The nerve fibers penetrated the junctions of the ensheathing satellite cells and myelin lamellae, and partly invaginated into the perikarya to establish axosomatic synapses. One small myelinated neuron with a nerve fiber synapse demonstrated multipolar cell processes. However, most small neurons with identical ultrastructural characteristics did not show these synapses. Axodendritic synapses were also seen on the dendritic processes of the small neurons and between varicose nerves and unmyelinated nerve fibers some distance from the small neurons. While these observations conform in some aspects with the concept of parasympathetic nerve fibers and neurons in the cochlea, they are also compatible with the idea that the small neurons may have an auditory function influenced by the synaptic contacts of efferent fibers from the olivocochlear bundle.

scholarly journals Simultaneous Quantification of Unmyelinated Nerve Fibers in Sural Nerve and in Skin

2015 ◽  
Vol 75 (1) ◽  
pp. 53-60 ◽  
Author(s):  
Mathilde Duchesne ◽  
Laurent Magy ◽  
Laurence Richard ◽  
Pierre Ingrand ◽  
Jean-Philippe Neau ◽  
...  
Keyword(s):  
Sural Nerve ◽  
Nerve Fibers ◽  
Simultaneous Quantification ◽  
Unmyelinated Nerve

scholarly journals The Pathological Features of Common Hereditary Mitochondrial Dynamics Neuropathy

2021 ◽  
Vol 15 ◽  
Author(s):  
Rui Wu ◽  
He Lv ◽  
Hui Wang ◽  
Zhaoxia Wang ◽  
Yun Yuan
Keyword(s):  
Morphological Changes ◽  
Mitochondrial Dynamics ◽  
Deep Tendon Reflex ◽  
Nerve Fibers ◽  
Sensory Loss ◽  
Mitofusin 2 ◽  
Charcot Marie Tooth Disease ◽  
Tendon Reflex ◽  
Unmyelinated Nerve ◽  
Related Proteins

ObjectivesMitofusin 2 and ganglioside-induced differentiation-associated protein 1 are two main mitochondrial dynamics-related proteins. Dysfunction of these two proteins leads to different subtypes of Charcot–Marie–Tooth disease type 2A (CMT2A) and CMT2K. This study aims to report the pathological difference between CMT2A and CMT2K in a large cohort.MethodsThirty patients with molecularly confirmed CMT2A and nine with CMT2K were identified by next-generation sequencing. Sural nerve biopsies were performed in 29 patients.ResultsThe patients with both diseases showed length-dependent neuropathy with distal weakness, sensory loss, and no deep tendon reflex. Optic neuropathy appeared in 3/30 (10%) patients with CMT2A. Tendon contracture appeared in 4/9 (50.0%) patients with CMT2K. Sural biopsy revealed the loss of both myelinated and unmyelinated nerve fibers. Closely packed, irregularly oriented neurofilaments were observed in axons of unmyelinated nerve fibers in both diseases. Another important finding was the ubiquitous presence of smaller, rounded, and fragmented mitochondria in CMT2A and elongated mitochondria in CMT2K in the myelinated and unmyelinated axons.ConclusionThis study confirmed large diversity in phenotypes between CMT2A and CMT2K. Mitochondrial dynamics-related variations can induce different mitochondrial morphological changes and neurofilament accumulation in axons.

Early diagnosis of diabetic polyneuropathy based on the results of corneal nerve fibers examination

2020 ◽  
Vol 136 (5) ◽  
pp. 155
Author(s):  
S.E. Avetisov ◽  
N.A. Chernenkova ◽  
Z.V. Surnina ◽  
L.T. Akhmedzhanova ◽  
A.S. Fokina ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Diabetic Polyneuropathy ◽  
Nerve Fibers ◽  
Corneal Nerve

Fine structure of the impulse-conducting system in rat heart

1970 ◽  
Vol 48 (4) ◽  
pp. 837-839 ◽  
Author(s):  
Haukur Melax ◽  
Thomas S. Leeson
Keyword(s):  
Sinoatrial Node ◽  
Atrioventricular Node ◽  
Nerve Fibers ◽  
Cardiac Cells ◽  
Loose Connective Tissue ◽  
Cardiac Muscle Cells ◽  
Myelinated Nerve ◽  
Specific Granules ◽  
Atrial Specific Granules ◽  
Unmyelinated Nerve

The sinoatrial node of the rat is composed of loosely interwoven modified cardiac muscle cells, which are lined up in groups to form somewhat irregular layers or plates. A generous amount of atrial specific granules is found in their cytoplasm. Between the nodal cells there is a loose connective tissue containing numerous bundles of unit fibrils of collagen and unmyelinated nerve fibers. In the atrioventricular node the modified cardiac cells are larger than those of the sinoatrial node, and are arranged in small groups. They contain a large amount of glycogen. Unmyelinated nerve fibers are extremely numerous in the atrioventricular node and myelinated nerve fibers are also present.

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