Conduction velocity in unmyelinated nerve fibers of a cutaneous nerve

1973 ◽  
Vol 76 (3) ◽  
pp. 1004-1007 ◽  
Author(s):  
A. V. Zeveke ◽  
V. I. Myaderov ◽  
V. A. Utkin ◽  
V. L. Shaposhnikov
Keyword(s):  
Conduction Velocity ◽  
Nerve Fibers ◽  
Cutaneous Nerve ◽  
Unmyelinated Nerve

New Developments in Microneurography of Human C Fibers

Physiology ◽  
1996 ◽  
Vol 11 (4) ◽  
pp. 170-175
Author(s):  
C Forster ◽  
M Schmelz
Keyword(s):  
Conduction Velocity ◽  
Refractory Period ◽  
Nerve Fibers ◽  
Cutaneous Nerve ◽  
New Developments ◽  
Relative Refractory Period ◽  
C Fibers ◽  
Highly Sensitive ◽  
Different Types

Slowing of conduction velocity during the relative refractory period of an axon can be used to detect activation in human cutaneous nerve fibers. The method is highly sensitive and provides the means to identify individual unmyelinated afferent and efferent (sympathetic) units excited by different types of stimuli.

Local Anesthetics Selectively Damage Schwann Cells of Unmyelinated Nerve Fibers

1987 ◽  
Vol 67 (3) ◽  
pp. A276-A276
Author(s):  
Robert R. Myers ◽  
Michael W. Kalichman ◽  
Henry C. Powell
Keyword(s):  
Schwann Cells ◽  
Local Anesthetics ◽  
Nerve Fibers ◽  
Unmyelinated Nerve

Activity-Dependent Modulation of Axonal Excitability in Unmyelinated Peripheral Rat Nerve Fibers by the 5-HT(3) Serotonin Receptor

2006 ◽  
Vol 96 (6) ◽  
pp. 2963-2971 ◽  
Author(s):  
Philip M. Lang ◽  
Gila Moalem-Taylor ◽  
David J. Tracey ◽  
Hugh Bostock ◽  
Peter Grafe
Keyword(s):  
Action Potential ◽  
Conduction Velocity ◽  
Action Potentials ◽  
Serotonin Receptor ◽  
Nerve Fibers ◽  
Nerve Trunk ◽  
Axonal Membrane ◽  
Membrane Hyperpolarization ◽  
Axonal Excitability ◽  
Activity Dependent

Activity-dependent fluctuations in axonal excitability and changes in interspike intervals modify the conduction of trains of action potentials in unmyelinated peripheral nerve fibers. During inflammation of a nerve trunk, long stretches of axons are exposed to inflammatory mediators such as 5-hydroxytryptamine [5-HT]. In the present study, we have tested the effects of m-chlorophenylbiguanide (mCPBG), an agonist at the 5-HT(3) serotonin receptor, on activity- and potential-dependent variations in membrane threshold and conduction velocity of unmyelinated C-fiber axons of isolated rat sural nerve segments. The increase in axonal excitability during application of mCPBG was much stronger at higher frequencies of action potentials and/or during axonal membrane hyperpolarization. The effects on the postspike recovery cycle also depended on the rate of stimulation. At an action potential frequency of 1 Hz or in hyperpolarized axons, mCPBG produced a loss of superexcitability. In contrast, at 0.33 Hz, a small increase in the postspike subexcitability was observed. Similar effects on excitability changes were found when latency instead of threshold was recorded, but only at higher action potential frequencies: at 1.8 Hz, mCPBG increased conduction velocity and reduced postspike supernormality. The latter effect would increase the interspike interval if pairs of action potentials were conducted along several cm in an inflamed nerve trunk. These data indicate that activation of axonal 5-HT(3) receptors not only enhances membrane excitability but also modulates action potential trains in unmyelinated, including nociceptive, nerve fibers at high impulse rates.

scholarly journals Reduced neurofilament expression in cutaneous nerve fibers of patients with CMT2E

Neurology ◽  
2015 ◽  
Vol 85 (3) ◽  
pp. 228-234 ◽  
Author(s):  
Chiara Pisciotta ◽  
Yunhong Bai ◽  
Kathryn M. Brennan ◽  
Xingyao Wu ◽  
Tiffany Grider ◽  
...  
Keyword(s):  
Nerve Fibers ◽  
Cutaneous Nerve
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