scholarly journals Effect of aging on sensory nerve conduction study parameters

2004 ◽  
Vol 29 (5) ◽  
pp. 716-720 ◽  
Author(s):  
Henry C. Tong ◽  
Robert A. Werner ◽  
Alfred Franzblau
2009 ◽  
Vol 120 (7) ◽  
pp. 1342-1345 ◽  
Author(s):  
Christian P. Kamm ◽  
Olivier Scheidegger ◽  
Kai M. Rösler

2018 ◽  
Vol 27 (4) ◽  
pp. 38-47
Author(s):  
Stella Papageorgiou ◽  
Konstantinos Krikonis ◽  
Jean-François Quinton ◽  
Kirsten Gnirs

Author(s):  
Umamaheshwari C. ◽  
Shanthi M. ◽  
Malathi M.

Background: Chemotherapy induced peripheral neuropathy is a significant disability after the treatment of large number of cancers and they have an impact on quality of life. The aim of the present endeavour was to study the cisplatin-paclitaxel induced peripheral neuropathy in patients with lung or ovarian cancerMethods: The study was carried out in the Department of Oncology, Government Rajaji Hospital, Madurai, after obtaining clearance from Institutional ethical committee, Government Rajaji Hospital, Madurai. Thirty newly diagnosed patients suffering from Lung or ovarian cancer attending Oncology department were selected. After satisfying inclusion and exclusion criteria. Patient received injection cisplatin 60 mg/m2 and injection paclitaxel 175 mg/m2. Nerve conduction study was done to assess the peripheral neuropathy. It was done before starting the chemotherapy. Patients with grade 0 neuropathy were included for the study. Nerve conduction study was repeated after each cycle. The time taken to develop peripheral neuropathy was assessed using Cancer Institute - Common Toxicity Criteria version 3.0. The data were analyzed with SPSS statistical software package (Version 16.0 SPSS Inc., Chicago, USA ).Results: There is a statistically significant reduction in sensory nerve (sural) amplitude (SNAP) and latency (p <0.05) indicating significant axonal damage. The time taken to develop peripheral neuropathy was 3 cycles with grade 3/4.Conclusions: In this present study, the neurotoxicity induced by cisplatin-paclitaxel in patients with lung or ovarian carcinoma was observed, so that early intervention can prevent the permanent neurotoxicity.


2012 ◽  
Vol 123 (5) ◽  
pp. 973-978 ◽  
Author(s):  
Hideharu Murashima ◽  
Masahiro Sonoo ◽  
Hiroshi Tsukamoto ◽  
Shingo Kawakami ◽  
Yasuomi Kawamura ◽  
...  

1970 ◽  
Vol 8 (3) ◽  
pp. 169-175 ◽  
Author(s):  
Dilip Thakur ◽  
BH Paudel ◽  
BK Bajaj ◽  
CB Jha

Background: Nerve conduction study (NCS) assesses peripheral nerve functions and has clinical implication. Objective: To study effect of gender on NCS variables in healthy adults. Settings and Design: Department of Physiology, B.P. Koirala Institute of Health Sciences, Dharan, Nepal. Material and Method: The study was done in 34 (m=19, 32±11 years; f=15, 32±12 years) consenting healthy adults. The compound muscle action potential (CMAP) and sensory nerve action potential (SNAP) were recorded. Statistical analysis: The effect of gender on NCS variables was analyzed using Mann Whitney U test. Results: Male vs. female: males had increased CMAP and F-wave latencies (ms) in all tested motor nerves. CMAP duration (ms) was longer in males (p<0.05) in all tested motor nerves: right median (5.9±1.3 vs. 4.92±0.65), left median (5.54±0.91 vs. 4.72±0.57), right ulnar (5.55±1.01 vs. 4.56±0.59), left ulnar (5.71±0.97 vs. 4.64±0.51), right tibial (6.58±0.95 vs. 5.95±0.71), and left tibial (6.98±1.31 vs. 6.21±0.78). Females showed higher sural SNAP amplitude (µV) (23.26±9.23 vs. 15.94±8.42). SNAP duration (ms) was longer in males: right ulnar (1.16±0.19 vs. 1.03±0.06). SNAP latencies (ms) were also longer in males: right sural (2.61±0.44 vs. 2.21±0.36). Males had greater height (165.9±4.74 vs. 149.3±7.24) and weight (60.4±7.2 vs. 53±7.2).Conclusion: Gender has definite effects on NCS variables. Males had higher CMAP amplitude, longer latencies and duration. SNAP latencies and duration were longer in males whereas amplitude was higher in females. Without adjustment for these factors, the sensitivity and specificity of NCS will decrease when using the same reference data in patients with different gender. Keywords: compound muscle action potential; gender; nerve conduction study; sensory nerve action potential DOI: 10.3126/hren.v8i3.4210Health Renaissance, September-December 2010; Vol 8 (No.3);169-175


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