scholarly journals Ultrashort echo time quantitative susceptibility mapping (UTE‐QSM) for detection of hemosiderin deposition in hemophilic arthropathy: A feasibility study

2020 ◽  
Vol 84 (6) ◽  
pp. 3246-3255
Author(s):  
Hyungseok Jang ◽  
Annette Drygalski ◽  
Jonathan Wong ◽  
Jenny Y. Zhou ◽  
Peter Aguero ◽  
...  
Keyword(s):  
Feasibility Study ◽  
Susceptibility Mapping ◽  
Quantitative Susceptibility Mapping ◽  
Ultrashort Echo Time ◽  
Hemophilic Arthropathy ◽  
Hemosiderin Deposition ◽  
Echo Time

scholarly journals Dynamic contrast-enhanced quantitative susceptibility mapping with ultrashort echo time MRI for evaluating renal function

2016 ◽  
Vol 310 (2) ◽  
pp. F174-F182 ◽  
Author(s):  
Luke Xie ◽  
Anita T. Layton ◽  
Nian Wang ◽  
Peder E. Z. Larson ◽  
Jeff L. Zhang ◽  
...  
Keyword(s):  
Renal Function ◽  
Renal Medulla ◽  
Susceptibility Mapping ◽  
Quantitative Susceptibility Mapping ◽  
Ultrashort Echo Time ◽  
Dce Mri ◽  
Dynamic Contrast Enhanced ◽  
Concentrating Mechanism ◽  
Contrast Enhanced ◽  
Echo Time

Dynamic contrast-enhanced (DCE) MRI can provide key insight into renal function. DCE MRI is typically achieved through an injection of a gadolinium (Gd)-based contrast agent, which has desirable T1 quenching and tracer kinetics. However, significant T2* blooming effects and signal voids can arise when Gd becomes very concentrated, especially in the renal medulla and pelvis. One MRI sequence designed to alleviate T2* effects is the ultrashort echo time (UTE) sequence. In the present study, we observed T2* blooming in the inner medulla of the mouse kidney, despite using UTE at an echo time of 20 microseconds and a low dose of 0.03 mmol/kg Gd. We applied quantitative susceptibility mapping (QSM) and resolved the signal void into a positive susceptibility signal. The susceptibility values [in parts per million (ppm)] were converted into molar concentrations of Gd using a calibration curve. We determined the concentrating mechanism (referred to as the concentrating index) as a ratio of maximum Gd concentration in the inner medulla to the renal artery. The concentrating index was assessed longitudinally over a 17-wk course (3, 5, 7, 9, 13, 17 wk of age). We conclude that the UTE-based DCE method is limited in resolving extreme T2* content caused by the kidney's strong concentrating mechanism. QSM was able to resolve and confirm the source of the blooming effect to be the large positive susceptibility of concentrated Gd. UTE with QSM can complement traditional magnitude UTE and offer a powerful tool to study renal pathophysiology.

scholarly journals Ultrashort Echo Time Quantitative Susceptibility Mapping (UTE-QSM) of Highly Concentrated Magnetic Nanoparticles: A Comparison Study about Different Sampling Strategies

Molecules ◽  
2019 ◽  
Vol 24 (6) ◽  
pp. 1143 ◽  
Author(s):  
Xing Lu ◽  
Hyungseok Jang ◽  
Yajun Ma ◽  
Saeed Jerban ◽  
Eric Chang ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Single Point ◽  
Susceptibility Mapping ◽  
Sampling Strategies ◽  
Comparison Study ◽  
Quantitative Susceptibility Mapping ◽  
Ultrashort Echo Time ◽  
Radial Acquisition ◽  
High Iron ◽  
Echo Time

The ability to accurately and non-invasively quantify highly concentrated magnetic nanoparticles (MNPs) is desirable for many emerging applications. Ultrashort echo time quantitative susceptibility mapping (UTE-QSM) has demonstrated the capability to detect high iron concentrations. In this study, we aimed to investigate the effect of different sampling trajectories on the accuracy of quantification based on MNPs acquired through UTE-QSM. A phantom with six different MNP concentrations was prepared for UTE-QSM study with different UTE sampling trajectories, including radial acquisition, continuous single point imaging (CSPI), and Cones with four different gradient stretching factors of 1.0, 1.2, 1.4, and 1.6. No significant differences were found in QSM values derived from the different UTE sampling strategies, suggesting that the UTE-QSM technique could be accelerated with extended Cones sampling.

scholarly journals Ultrashort echo time MRI of cortical bone at 7 tesla field strength: A feasibility study

2011 ◽  
Vol 34 (3) ◽  
pp. 691-695 ◽  
Author(s):  
Roland Krug ◽  
Peder Eric Zufall Larson ◽  
Chunsheng Wang ◽  
Andrew J. Burghardt ◽  
Douglas A.C. Kelley ◽  
...  
Keyword(s):  
Field Strength ◽  
Cortical Bone ◽  
Feasibility Study ◽  
7 Tesla ◽  
Ultrashort Echo Time ◽  
Echo Time

scholarly journals Echo time‐dependent quantitative susceptibility mapping contains information on tissue properties

2016 ◽  
Vol 77 (5) ◽  
pp. 1946-1958 ◽  
Author(s):  
Surabhi Sood ◽  
Javier Urriola ◽  
David Reutens ◽  
Kieran O’Brien ◽  
Steffen Bollmann ◽  
...  
Keyword(s):  
Susceptibility Mapping ◽  
Time Dependent ◽  
Quantitative Susceptibility Mapping ◽  
Tissue Properties ◽  
Echo Time

scholarly journals Ultrashort echo time imaging of normal middle ear ossicles: a feasibility study

2012 ◽  
Vol 41 (7) ◽  
pp. 601-604 ◽  
Author(s):  
K Yamashita ◽  
T Yoshiura ◽  
A Hiwatashi ◽  
H Kamano ◽  
H Honda
Keyword(s):  
Feasibility Study ◽  
Middle Ear ◽  
Ultrashort Echo Time ◽  
Ear Ossicles ◽  
Echo Time

Echo-time dependency of quantitative susceptibility mapping reproducibility at different magnetic field strengths

NeuroImage ◽  
2019 ◽  
Vol 197 ◽  
pp. 557-564 ◽  
Author(s):  
Marta Lancione ◽  
Graziella Donatelli ◽  
Paolo Cecchi ◽  
Mirco Cosottini ◽  
Michela Tosetti ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Susceptibility Mapping ◽  
Time Dependency ◽  
Quantitative Susceptibility Mapping ◽  
Echo Time ◽  
Field Strengths

Investigating Optimal Echo Times for Quantitative Susceptibility Mapping of Basal Ganglia Nuclei in the Healthy Brain

2020 ◽  
Vol 16 (8) ◽  
pp. 991-996
Author(s):  
Wenping Fan ◽  
Xue Wang ◽  
Xingwen Zhang ◽  
Mengqi Liu ◽  
Qinglin Meng ◽  
...  
Keyword(s):  
Magnetic Susceptibility ◽  
Clinical Practice ◽  
Standard Deviation ◽  
Basal Ganglia ◽  
Caudate Nucleus ◽  
Susceptibility Mapping ◽  
Quantitative Susceptibility Mapping ◽  
Significant Difference ◽  
The Mean ◽  
Echo Time

Background: Quantitative susceptibility mapping (QSM) technique had been used to measure the magnetic susceptibility of brain tissue in clinical practice. However, QSM presented echo-time (TE) dependence, and an appropriate number of echo-times (nTEs) for QSM became more important to obtain the reliable susceptibility value. Objective: The aim of the study was to explore the optimal nTEs for quantitative susceptibility mapping (QSM) measurements of basal ganglia nuclei in the healthy brain. Methods: 3D multi-echo enhanced gradient recalled echo T2 star weighted angiography (ESWAN) sequence was acquired on a 3.0T MR scanner for QSM analysis. Regions of interests (ROIs) were drawn along the margin of the head of the caudate nucleus (HCN), putamen (Pu) and globus pallidus (GP). The mean susceptibility value and standard deviation of the ROIs were derived from the pixels within each region. Results: CV analysis demonstrated that TE6, TE8 and TE14 ESWAN sequences presented consistent lower CV value (<1) for QSM measure of HCN, Pu and GP. ANOVA identified that susceptibility value showed no significant difference between TE6 and TE8 in HCN, Pu and GP (P > 0.05). ICC analysis demonstrated that the susceptibility value of TE6-TE8 had the highest ICC value as compared with TE6-TE14 and TE8-TE14 in HCN, Pu and GP. Combined with the timeefficiency of MRI scanning, TE6 sequence could not only provide the reliable QSM measurement but also short imaging time. Conclusions: The current study identified that the optimal nTEs of ESWAN were 6 TEs (2.9ms ~ 80.9ms) for QSM measurement of basal ganglia nuclei in the healthy brain.

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