scholarly journals Simultaneous quantitative susceptibility mapping (QSM) and for high iron concentration quantification with 3D ultrashort echo time sequences: An echo dependence study

2018 ◽  
Vol 79 (4) ◽  
pp. 2315-2322 ◽  
Author(s):  
Xing Lu ◽  
Yajun Ma ◽  
Eric Y. Chang ◽  
Qun He ◽  
Adam Searleman ◽  
...  
Keyword(s):  
Iron Concentration ◽  
Susceptibility Mapping ◽  
Quantitative Susceptibility Mapping ◽  
Ultrashort Echo Time ◽  
High Iron ◽  
High Iron Concentration ◽  
Echo Time ◽  
Time Sequences

scholarly journals Ultrashort Echo Time Quantitative Susceptibility Mapping (UTE-QSM) of Highly Concentrated Magnetic Nanoparticles: A Comparison Study about Different Sampling Strategies

Molecules ◽  
2019 ◽  
Vol 24 (6) ◽  
pp. 1143 ◽  
Author(s):  
Xing Lu ◽  
Hyungseok Jang ◽  
Yajun Ma ◽  
Saeed Jerban ◽  
Eric Chang ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Single Point ◽  
Susceptibility Mapping ◽  
Sampling Strategies ◽  
Comparison Study ◽  
Quantitative Susceptibility Mapping ◽  
Ultrashort Echo Time ◽  
Radial Acquisition ◽  
High Iron ◽  
Echo Time

The ability to accurately and non-invasively quantify highly concentrated magnetic nanoparticles (MNPs) is desirable for many emerging applications. Ultrashort echo time quantitative susceptibility mapping (UTE-QSM) has demonstrated the capability to detect high iron concentrations. In this study, we aimed to investigate the effect of different sampling trajectories on the accuracy of quantification based on MNPs acquired through UTE-QSM. A phantom with six different MNP concentrations was prepared for UTE-QSM study with different UTE sampling trajectories, including radial acquisition, continuous single point imaging (CSPI), and Cones with four different gradient stretching factors of 1.0, 1.2, 1.4, and 1.6. No significant differences were found in QSM values derived from the different UTE sampling strategies, suggesting that the UTE-QSM technique could be accelerated with extended Cones sampling.

scholarly journals Dynamic contrast-enhanced quantitative susceptibility mapping with ultrashort echo time MRI for evaluating renal function

2016 ◽  
Vol 310 (2) ◽  
pp. F174-F182 ◽  
Author(s):  
Luke Xie ◽  
Anita T. Layton ◽  
Nian Wang ◽  
Peder E. Z. Larson ◽  
Jeff L. Zhang ◽  
...  
Keyword(s):  
Renal Function ◽  
Renal Medulla ◽  
Susceptibility Mapping ◽  
Quantitative Susceptibility Mapping ◽  
Ultrashort Echo Time ◽  
Dce Mri ◽  
Dynamic Contrast Enhanced ◽  
Concentrating Mechanism ◽  
Contrast Enhanced ◽  
Echo Time

Dynamic contrast-enhanced (DCE) MRI can provide key insight into renal function. DCE MRI is typically achieved through an injection of a gadolinium (Gd)-based contrast agent, which has desirable T1 quenching and tracer kinetics. However, significant T2* blooming effects and signal voids can arise when Gd becomes very concentrated, especially in the renal medulla and pelvis. One MRI sequence designed to alleviate T2* effects is the ultrashort echo time (UTE) sequence. In the present study, we observed T2* blooming in the inner medulla of the mouse kidney, despite using UTE at an echo time of 20 microseconds and a low dose of 0.03 mmol/kg Gd. We applied quantitative susceptibility mapping (QSM) and resolved the signal void into a positive susceptibility signal. The susceptibility values [in parts per million (ppm)] were converted into molar concentrations of Gd using a calibration curve. We determined the concentrating mechanism (referred to as the concentrating index) as a ratio of maximum Gd concentration in the inner medulla to the renal artery. The concentrating index was assessed longitudinally over a 17-wk course (3, 5, 7, 9, 13, 17 wk of age). We conclude that the UTE-based DCE method is limited in resolving extreme T2* content caused by the kidney's strong concentrating mechanism. QSM was able to resolve and confirm the source of the blooming effect to be the large positive susceptibility of concentrated Gd. UTE with QSM can complement traditional magnitude UTE and offer a powerful tool to study renal pathophysiology.

scholarly journals Comparison of two ultrashort echo time sequences for the quantification ofT1within phantom and human Achilles tendon at 3 T

2012 ◽  
Vol 68 (4) ◽  
pp. 1279-1284 ◽  
Author(s):  
Peter Wright ◽  
Vladimir Jellus ◽  
Dennis McGonagle ◽  
Matthew Robson ◽  
John Ridgeway ◽  
...  
Keyword(s):  
Achilles Tendon ◽  
Ultrashort Echo Time ◽  
Echo Time ◽  
Time Sequences

scholarly journals MRI estimates of brain iron concentration in normal aging using quantitative susceptibility mapping

NeuroImage ◽  
2012 ◽  
Vol 59 (3) ◽  
pp. 2625-2635 ◽  
Author(s):  
Berkin Bilgic ◽  
Adolf Pfefferbaum ◽  
Torsten Rohlfing ◽  
Edith V. Sullivan ◽  
Elfar Adalsteinsson
Keyword(s):  
Iron Concentration ◽  
Normal Aging ◽  
Susceptibility Mapping ◽  
Brain Iron ◽  
Quantitative Susceptibility Mapping ◽  
Brain Iron Concentration

scholarly journals MRI-Based Attenuation Correction for PET/MRI Using Ultrashort Echo Time Sequences

2010 ◽  
Vol 51 (5) ◽  
pp. 812-818 ◽  
Author(s):  
V. Keereman ◽  
Y. Fierens ◽  
T. Broux ◽  
Y. De Deene ◽  
M. Lonneux ◽  
...  
Keyword(s):  
Attenuation Correction ◽  
Ultrashort Echo Time ◽  
Echo Time ◽  
Time Sequences

scholarly journals Echo time‐dependent quantitative susceptibility mapping contains information on tissue properties

2016 ◽  
Vol 77 (5) ◽  
pp. 1946-1958 ◽  
Author(s):  
Surabhi Sood ◽  
Javier Urriola ◽  
David Reutens ◽  
Kieran O’Brien ◽  
Steffen Bollmann ◽  
...  
Keyword(s):  
Susceptibility Mapping ◽  
Time Dependent ◽  
Quantitative Susceptibility Mapping ◽  
Tissue Properties ◽  
Echo Time
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