scholarly journals Triple diffusion encoding MRI predicts intra‐axonal and extra‐axonal diffusion tensors in white matter

2019 ◽  
Vol 83 (6) ◽  
pp. 2209-2220 ◽  
Author(s):  
Sudhir Ramanna ◽  
Hunter G. Moss ◽  
Emilie T. McKinnon ◽  
Essa Yacoub ◽  
Joseph A. Helpern ◽  
...  
Keyword(s):  
White Matter ◽  
Diffusion Tensors

Human Brain Diffusion Tensor Imaging Visualization With Virtual Reality

2010 ◽  
Author(s):  
Bin Chen ◽  
John Moreland
Keyword(s):  
Virtual Reality ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Biological Tissues ◽  
Head Tracking ◽  
Fiber Tractography ◽  
Brain White Matter ◽  
Diffusion Tensors ◽  
Visualization Techniques

Magnetic resonance diffusion tensor imaging (DTI) is sensitive to the anisotropic diffusion of water exerted by its macromolecular environment and has been shown useful in characterizing structures of ordered tissues such as the brain white matter, myocardium, and cartilage. The water diffusivity inside of biological tissues is characterized by the diffusion tensor, a rank-2 symmetrical 3×3 matrix, which consists of six independent variables. The diffusion tensor contains much information of diffusion anisotropy. However, it is difficult to perceive the characteristics of diffusion tensors by looking at the tensor elements even with the aid of traditional three dimensional visualization techniques. There is a need to fully explore the important characteristics of diffusion tensors in a straightforward and quantitative way. In this study, a virtual reality (VR) based MR DTI visualization with high resolution anatomical image segmentation and registration, ROI definition and neuronal white matter fiber tractography visualization and fMRI activation map integration is proposed. The VR application will utilize brain image visualization techniques including surface, volume, streamline and streamtube rendering, and use head tracking and wand for navigation and interaction, the application will allow the user to switch between different modalities and visualization techniques, as well making point and choose queries. The main purpose of the application is for basic research and clinical applications with quantitative and accurate measurements to depict the diffusivity or the degree of anisotropy derived from the diffusion tensor.

scholarly journals Adjugate Diffusion Tensors for Geodesic Tractography in White Matter

2015 ◽  
Vol 54 (1) ◽  
pp. 1-14 ◽  
Author(s):  
Andrea Fuster ◽  
Tom Dela Haije ◽  
Antonio Tristán-Vega ◽  
Birgit Plantinga ◽  
Carl-Fredrik Westin ◽  
...  
Keyword(s):  
White Matter ◽  
Diffusion Tensors

scholarly journals Varying coefficient model for modeling diffusion tensors along white matter tracts

2013 ◽  
Vol 7 (1) ◽  
pp. 102-125 ◽  
Author(s):  
Ying Yuan ◽  
Hongtu Zhu ◽  
Martin Styner ◽  
John H. Gilmore ◽  
J. S. Marron
Keyword(s):  
White Matter ◽  
Varying Coefficient Model ◽  
White Matter Tracts ◽  
Varying Coefficient ◽  
Diffusion Tensors

FT-IR microspectroscopic analysis of diseased white matter brain tissues

1995 ◽  
Vol 53 ◽  
pp. 968-969
Author(s):  
Steven M. Le Vine ◽  
David L. Wetzel
Keyword(s):  
White Matter ◽  
Gray Matter ◽  
Twitcher Mouse ◽  
Grid Pattern ◽  
Marked Contrast ◽  
Spatially Resolved ◽  
Ft Ir ◽  
Ir Microspectroscopy ◽  
Chemical Evidence

In situ FT-IR microspectroscopy has allowed spatially resolved interrogation of different parts of brain tissue. In previous work the spectrrscopic features of normal barin tissue were characterized. The white matter, gray matter and basal ganglia were mapped from appropriate peak area measurements from spectra obtained in a grid pattern. Bands prevalent in white matter were mostly associated with the lipid. These included 2927 and 1469 cm-1 due to CH2 as well as carbonyl at 1740 cm-1. Also 1235 and 1085 cm-1 due to phospholipid and galactocerebroside, respectively (Figs 1and2). Localized chemical changes in the white matter as a result of white matter diseases have been studied. This involved the documentation of localized chemical evidence of demyelination in shiverer mice in which the spectra of white matter lacked the marked contrast between it and gray matter exhibited in the white matter of normal mice (Fig. 3).The twitcher mouse, a model of Krabbe’s desease, was also studied. The purpose in this case was to look for a localized build-up of psychosine in the white matter caused by deficiencies in the enzyme responsible for its breakdown under normal conditions.

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