scholarly journals Mathematical models for diffusion-weighted imaging of prostate cancer using b values up to 2000 s/mm2 : Correlation with Gleason score and repeatability of region of interest analysis

2014 ◽  
Vol 74 (4) ◽  
pp. 1116-1124 ◽  
Author(s):  
Jussi Toivonen ◽  
Harri Merisaari ◽  
Marko Pesola ◽  
Pekka Taimen ◽  
Peter J. Boström ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Mathematical Models ◽  
Gleason Score ◽  
Diffusion Weighted Imaging ◽  
Region Of Interest ◽  
B Values ◽  
Diffusion Weighted

scholarly journals Statistical Evaluation of Different Mathematical Models for Diffusion Weighted Imaging of Prostate Cancer Xenografts in Mice

2021 ◽  
Vol 11 ◽  
Author(s):  
Harri Merisaari ◽  
Hanne Laakso ◽  
Heidi Liljenbäck ◽  
Helena Virtanen ◽  
Hannu J. Aronen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Growth ◽  
Mathematical Models ◽  
Diffusion Weighted Imaging ◽  
Exponential Model ◽  
Information Criteria ◽  
B Values ◽  
Stretched Exponential ◽  
Diffusion Weighted ◽  
Mouse Xenograft Model

PurposeTo evaluate fitting quality and repeatability of four mathematical models for diffusion weighted imaging (DWI) during tumor progression in mouse xenograft model of prostate cancer.MethodsHuman prostate cancer cells (PC-3) were implanted subcutaneously in right hind limbs of 11 immunodeficient mice. Tumor growth was followed by weekly DWI examinations using a 7T MR scanner. Additional DWI examination was performed after repositioning following the fourth DWI examination to evaluate short term repeatability. DWI was performed using 15 and 12 b-values in the ranges of 0-500 and 0-2000 s/mm2, respectively. Corrected Akaike information criteria and F-ratio were used to evaluate fitting quality of each model (mono-exponential, stretched exponential, kurtosis, and bi-exponential).ResultsSignificant changes were observed in DWI data during the tumor growth, indicated by ADCm, ADCs, and ADCk. Similar results were obtained using low as well as high b-values. No marked changes in model preference were present between the weeks 1−4. The parameters of the mono-exponential, stretched exponential, and kurtosis models had smaller confidence interval and coefficient of repeatability values than the parameters of the bi-exponential model.ConclusionStretched exponential and kurtosis models showed better fit to DWI data than the mono-exponential model and presented with good repeatability.

Stimulated-echo diffusion-weighted imaging with moderate b values for the detection of prostate cancer

2020 ◽  
Vol 30 (6) ◽  
pp. 3236-3244
Author(s):  
Yuxin Zhang ◽  
Shane A. Wells ◽  
Benjamin L. Triche ◽  
Frederick Kelcz ◽  
Diego Hernando
Keyword(s):  
Prostate Cancer ◽  
Diffusion Weighted Imaging ◽  
B Values ◽  
Diffusion Weighted ◽  
Stimulated Echo
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