scholarly journals Imaging neurodegeneration in the mouse hippocampus after neonatal hypoxia-ischemia using oscillating gradient diffusion MRI

2013 ◽  
Vol 72 (3) ◽  
pp. 829-840 ◽  
Author(s):  
Manisha Aggarwal ◽  
Jennifer Burnsed ◽  
Lee J. Martin ◽  
Frances J. Northington ◽  
Jiangyang Zhang
Keyword(s):  
Diffusion Mri ◽  
Neonatal Hypoxia ◽  
Gradient Diffusion ◽  
Hypoxia Ischemia ◽  
Mouse Hippocampus

scholarly journals Oscillating-gradient diffusion magnetic resonance imaging detects acute subcellular structural changes in the mouse forebrain after neonatal hypoxia-ischemia

2018 ◽  
Vol 39 (7) ◽  
pp. 1336-1348 ◽  
Author(s):  
Dan Wu ◽  
Lee J Martin ◽  
Frances J Northington ◽  
Jiangyang Zhang
Keyword(s):  
Diffusion Mri ◽  
Structural Changes ◽  
Spatial Scales ◽  
Brain Structures ◽  
Contralateral Side ◽  
Neonatal Hypoxia ◽  
Gradient Diffusion ◽  
Hypoxia Ischemia ◽  
Apparent Diffusion

The recently developed oscillating-gradient diffusion MRI (OG-dMRI) technique extends our ability to examine brain structures at different spatial scales. In this study, we investigated the sensitivity of OG-dMRI in detecting cellular and subcellular structural changes in a mouse model of neonatal hypoxia ischemia (HI). Neonatal mice received unilateral HI injury or sham injury at postnatal day 10, followed by in vivo T2-weighted and diffusion MRI of the brains at 3–6 h and 24 h after HI. Apparent diffusion coefficient (ADC) maps were acquired using conventional pulsed-gradient dMRI (PG-dMRI) and OG-dMRI with oscillating frequencies from 50 to 200 Hz. Pathology at cellular and subcellular levels was evaluated using neuronal, glial, and mitochondrial markers. We found significantly higher rates of ADC increase with oscillating frequencies (Δ fADC) in the ipsilateral edema region, compared to the contralateral side, starting as early as 3 h after HI. Even in injured regions that showed no apparent change in PG-ADC or pseudo-normalized PG-ADC measurements, Δ fADC remained significantly elevated. Histopathology showed swelling of sub-cellular structures in these regions with no apparent whole-cell level change. These results suggest that OG-dMRI is sensitive to subcellular structural changes in the brain after HI and is less susceptible to pseudo-normalization than PG-dMRI.

scholarly journals Oscillating gradient diffusion MRI reveals unique microstructural information in normal and hypoxia-ischemia injured mouse brains

2014 ◽  
Vol 72 (5) ◽  
pp. 1366-1374 ◽  
Author(s):  
Dan Wu ◽  
Lee J. Martin ◽  
Frances J. Northington ◽  
Jiangyang Zhang
Keyword(s):  
Diffusion Mri ◽  
Gradient Diffusion ◽  
Hypoxia Ischemia

scholarly journals Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxia-ischemia

Autophagy ◽  
2010 ◽  
Vol 6 (3) ◽  
pp. 366-377 ◽  
Author(s):  
Silvia Carloni ◽  
Silvia Girelli ◽  
Claudia Scopa ◽  
Giuseppe Buonocore ◽  
Mariangela Longini ◽  
...  
Keyword(s):  
Neuroprotective Effect ◽  
Neonatal Hypoxia ◽  
Hypoxia Ischemia

scholarly journals The nonerythropoietic asialoerythropoietin protects against neonatal hypoxia-ischemia as potently as erythropoietin

2004 ◽  
Vol 91 (4) ◽  
pp. 900-910 ◽  
Author(s):  
Xiaoyang Wang ◽  
Changlian Zhu ◽  
Xinhua Wang ◽  
Jens Gammeltoft Gerwien ◽  
Andre Schrattenholz ◽  
...  
Keyword(s):  
Neonatal Hypoxia ◽  
Hypoxia Ischemia

scholarly journals Splenic Immune Cells in Experimental Neonatal Hypoxia–Ischemia

2012 ◽  
Vol 4 (2) ◽  
pp. 208-219 ◽  
Author(s):  
Nancy Fathali ◽  
Robert P. Ostrowski ◽  
Yu Hasegawa ◽  
Tim Lekic ◽  
Jiping Tang ◽  
...  
Keyword(s):  
Immune Cells ◽  
Neonatal Hypoxia ◽  
Hypoxia Ischemia

Neonatal hypoxia-ischemia caused mild motor dysfunction, recovered by acrobatic training, without affecting morphological structures involved in motor control in rats

2019 ◽  
Vol 1707 ◽  
pp. 27-44 ◽  
Author(s):  
Heloísa Deola Confortim ◽  
Bruna Ferrary Deniz ◽  
Wellington de Almeida ◽  
Patrícia Maidana Miguel ◽  
Loise Bronauth ◽  
...  
Keyword(s):  
Motor Control ◽  
Motor Dysfunction ◽  
Neonatal Hypoxia ◽  
Hypoxia Ischemia

Experimental neonatal hypoxia ischemia causes long lasting changes of oxidative stress parameters in the hippocampus and the spleen

2018 ◽  
Vol 46 (4) ◽  
pp. 433-439 ◽  
Author(s):  
Felipe Kawa Odorcyk ◽  
Janaína Kolling ◽  
Eduardo Farias Sanches ◽  
Angela T.S. Wyse ◽  
Carlos Alexandre Netto
Keyword(s):  
Oxidative Stress ◽  
Wistar Rat ◽  
Mortality And Morbidity ◽  
Neonatal Hypoxia ◽  
Oxidative Stress Parameters ◽  
Rat Pups ◽  
Hypoxia Ischemia ◽  
Anti Oxidant ◽  
Enzyme Superoxide Dismutase ◽  
Stress Parameters

Abstract Neonatal hypoxia ischemia (HI) is the main cause of mortality and morbidity in newborns. The mechanisms involved in its progression start immediately and persist for several days. Oxidative stress and inflammation are determinant factors of the severity of the final lesion. The spleen plays a major part in the inflammatory response to HI. This study assessed the temporal progression of HI-induced alterations in oxidative stress parameters in the hippocampus, the most affected brain structure, and in the spleen. HI was induced in Wistar rat pups in post-natal day 7. Production of reactive oxygen species (ROS), and the activity of the anti oxidant enzyme superoxide dismutase and catalase were assessed 24 h, 96 h and 38 days post-HI. Interestingly, both structures showed a similar pattern, with few alterations in the production of ROS species up to 96 h often combined with an increased activity of the anti oxidant enzymes. However, 38 days after the injury, ROS were at the highest in both structures, coupled with a decrease in the activity of the enzymes. Altogether, present results suggest that HI causes long lasting alterations in the hippocampus as well as in the spleen, suggesting a possible target for delayed treatments for HI.

scholarly journals Probing mouse brain microstructure using oscillating gradient diffusion MRI

2011 ◽  
Vol 67 (1) ◽  
pp. 98-109 ◽  
Author(s):  
Manisha Aggarwal ◽  
Melina V. Jones ◽  
Peter A. Calabresi ◽  
Susumu Mori ◽  
Jiangyang Zhang
Keyword(s):  
Mouse Brain ◽  
Diffusion Mri ◽  
Gradient Diffusion ◽  
Brain Microstructure
Sign in / Sign up

Export Citation Format

Share Document