Separation of macrovascular signal in multi-inversion time arterial spin labelling MRI

2010 ◽  
Vol 63 (5) ◽  
pp. 1357-1365 ◽  
Author(s):  
Michael A. Chappell ◽  
Bradley J. MacIntosh ◽  
Manus J. Donahue ◽  
Matthias Günther ◽  
Peter Jezzard ◽  
...  
Keyword(s):  
Arterial Spin Labelling ◽  
Inversion Time ◽  
Spin Labelling

scholarly journals In vivo Assessment of Human Brainstem Cerebrovascular Function: A Multi-Inversion Time Pulsed Arterial Spin Labelling Study

2014 ◽  
Vol 34 (6) ◽  
pp. 956-963 ◽  
Author(s):  
Esther AH Warnert ◽  
Ashley D Harris ◽  
Kevin Murphy ◽  
Neeraj Saxena ◽  
Neeta Tailor ◽  
...  
Keyword(s):  
Repeated Measures ◽  
Vascular Reactivity ◽  
Kinetic Curve ◽  
Tissue Perfusion ◽  
Compartment Model ◽  
Arterial Spin Labelling ◽  
Inversion Time ◽  
Cerebrovascular Function ◽  
Spin Labelling

The brainstem (BS) is involved in critical physiologic processes, including control of cardiovascular and respiratory functions. This study implements a multi-inversion time pulsed arterial spin labelling (MTI PASL) imaging sequence that addresses the challenges of BS imaging and aims to measure normal and elevated BS perfusion in healthy volunteers. An initial experiment was performed to obtain the kinetic curve of the label in the BS and consequently to estimate the label arrival times and tissue perfusion in seven participants. A second experiment estimated the BS cerebral vascular reactivity (CVR) to hypercapnia in 10 participants. Images were acquired with a gradient-echo sequence with two spiral interleaves and short echo time (TE = 2.7 ms). Data were analyzed with a two-compartment model, including a tissue and arterial component. In both experiments, perfusion in the BS was significantly lower than in cortical gray matter (repeated measures analysis of variance (RM-ANOVA), P<0.05), which is as expected since the BS consists of gray and white matter, the latter typically showing lower perfusion. The BS CVR found here is comparable to previous reports obtained with positron emission tomography (PET) imaging. Multi-inversion time pulsed ASL in combination with a two-compartment signal model can be used to assess BS perfusion and CVR.

scholarly journals Assessment of the effects of aerobic fitness on cerebrovascular function in young adults using multiple inversion time arterial spin labelling MRI

2019 ◽  
Author(s):  
Catherine Foster ◽  
Jessica J Steventon ◽  
Daniel Helme ◽  
Valentina Tomassini ◽  
Richard G. Wise
Keyword(s):  
Young Adults ◽  
Aerobic Fitness ◽  
Arterial Spin Labelling ◽  
Cerebrovascular Reactivity ◽  
Inverse Association ◽  
Cross Sectional ◽  
Whole Brain ◽  
Inversion Time ◽  
Cerebrovascular Function ◽  
Spin Labelling

AbstractThe cross-sectional study investigated the effects of aerobic fitness on cerebrovascular function in the healthy brain. We quantified grey matter (GM) cerebral blood flow (CBF) and cerebrovascular reactivity (CVR), in a sample of young adults within a normal fitness range. Based on existing TCD and fMRI evidence, we predicted a positive relationship between fitness and resting GM CBF, and CVR. Exploratory hypotheses that higher peak would be associated with higher GM volume and cognitive performance were also investigated.20 adults underwent a peak test and a battery of cognitive tests. All subjects underwent an MRI scan where multiple inversion time (MTI) pulsed arterial spin labelling (PASL) was used to quantify resting CBF and CVR to 5% CO2.ROI analysis showed a non-significant negative correlation between whole-brain GM CBF and peak; r=-0.4, p=0.08, corrected p (p’) =0.16 and a significant positive correlation between peak and voxelwise whole-brain GM CVR; r=0.62, p=0.003, p’ =0.006. Voxelwise analysis revealed a significant inverse association between peak and resting CBF in the left and right thalamus, brainstem, right lateral occipital cortex, left intracalcarine cortex and cerebellum. The results of this study suggest that aerobic fitness is associated with lower CBF and greater CVR in young adults.

scholarly journals Advanced magnetic resonance imaging of cortical laminar necrosis in patients with stroke

2019 ◽  
Vol 32 (6) ◽  
pp. 431-437 ◽  
Author(s):  
Roberto Cannella ◽  
Gianvincenzo Sparacia ◽  
Vincenzina Lo Re ◽  
Elisa Oddo ◽  
Giuseppe Mamone ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Acute Stage ◽  
Arterial Spin Labelling ◽  
Resonance Imaging ◽  
Cortical Laminar Necrosis ◽  
Diffusion Weighted ◽  
Cortical Laminar ◽  
Laminar Necrosis ◽  
Spin Labelling

Purpose The aim of this study was to assess the novel advanced magnetic resonance imaging findings of acute stage cortical laminar necrosis developing after complicated cardiovascular or abdominal surgery. Materials and methods This institutional review board-approved study included patients with postoperative stroke due to cortical laminar necrosis imaged with magnetic resonance in the acute stage. Brain magnetic resonance imaging examinations were obtained on a 3T magnetic resonance scanner within 48 hours of the neurological symptoms, including diffusion-weighted images (b value, 1000 s/mm2) and arterial spin labelling using a pseudo-continuous arterial spin labelling method in four patients. Conventional and advanced magnetic resonance images were analysed to assess the imaging features in acute stage cortical laminar necrosis. Results The final population consisted of 14 patients (seven men and seven women, mean age 61 years, range 32–79 years) diagnosed with stroke and acute phase cortical laminar necrosis. All the patients presented with cortical lesions showing restricted diffusion on diffusion-weighted images and hypointensity on the apparent diffusion coefficient map. Cortical hyperintensity on T2-weighted or fluid-attenuated inversion recovery images was found in three (21%) and six (43%) patients, respectively. Reduced perfusion was noted in three out of four patients imaged with arterial spin labelling, while in one case no corresponding perfusion abnormality was noted on the arterial spin labelling maps. Arterial spin labelling abnormalities were much more extensive than diffusion restriction in two patients, and they were associated with a poor outcome. Conclusion Cortical hyperintense abnormalities on diffusion-weighted imaging may be the only sign of developing cortical laminar necrosis injury. The acquisition of arterial spin labelling helps to identify perfusion alterations and the extension of the ischaemic injury.

Repeatability of perfusion measurements in adult gliomas using pulsed and pseudo-continuous arterial spin labelling MRI

2021 ◽  
Author(s):  
Amirah Faisal Alsaedi ◽  
David Lee Thomas ◽  
Enrico De Vita ◽  
Jasmina Panovska-Griffiths ◽  
Sotirios Bisdas ◽  
...  
Keyword(s):  
Arterial Spin Labelling ◽  
Perfusion Measurements ◽  
Spin Labelling

scholarly journals Quantitative blood flow measurement in rat brain with multiphase arterial spin labelling magnetic resonance imaging

2018 ◽  
Vol 39 (8) ◽  
pp. 1557-1569 ◽  
Author(s):  
James R Larkin ◽  
Manon A Simard ◽  
Alexandre A Khrapitchev ◽  
James A Meakin ◽  
Thomas W Okell ◽  
...  
Keyword(s):  
Blood Flow ◽  
Flow Measurement ◽  
Arterial Spin Labelling ◽  
Sprague Dawley ◽  
Functional Studies ◽  
Non Invasive ◽  
Disease States ◽  
Preclinical Mri ◽  
Invasive Measurement ◽  
Spin Labelling

Cerebral blood flow is an important parameter in many diseases and functional studies that can be accurately measured in humans using arterial spin labelling (ASL) MRI. However, although rat models are frequently used for preclinical studies of both human disease and brain function, rat CBF measurements show poor consistency between studies. This lack of reproducibility is due, partly, to the smaller size and differing head geometry of rats compared to humans, as well as the differing analysis methodologies employed and higher field strengths used for preclinical MRI. To address these issues, we have implemented, optimised and validated a multiphase pseudo-continuous ASL technique, which overcomes many of the limitations of rat CBF measurement. Three rat strains (Wistar, Sprague Dawley and Berlin Druckrey IX) were used, and CBF values validated against gold-standard autoradiography measurements. Label positioning was found to be optimal at 45°, while post-label delay was optimised to 0.55 s. Whole brain CBF measures were 109 ± 22, 111 ± 18 and 100 ± 15 mL/100 g/min by multiphase pCASL, and 108 ± 12, 116 ± 14 and 122 ± 16 mL/100 g/min by autoradiography in Wistar, SD and BDIX cohorts, respectively. Tumour model analysis shows that the developed methods also apply in disease states. Thus, optimised multiphase pCASL provides robust, reproducible and non-invasive measurement of CBF in rats.

P2-391: NON-INVASIVE IMAGING OF BRAIN CLEARANCE PATHWAYS USING MULTIPLE ECHO TIME ARTERIAL SPIN LABELLING: AN AQUAPORIN-4 STUDY

2006 ◽  
Vol 14 (7S_Part_15) ◽  
pp. P851-P852
Author(s):  
Yolanda Ohene ◽  
Ian F. Harrison ◽  
Payam Nahavandi ◽  
Ozama Ismail ◽  
Ole P. Ottersen ◽  
...  
Keyword(s):  
Arterial Spin Labelling ◽  
Aquaporin 4 ◽  
Non Invasive ◽  
Echo Time ◽  
Spin Labelling

3D GRASE arterial spin labelling reveals an inverse correlation of cortical perfusion with the white matter lesion volume in MS

2012 ◽  
Vol 18 (11) ◽  
pp. 1570-1576 ◽  
Author(s):  
Michael Amann ◽  
Lutz Achtnichts ◽  
Jochen G Hirsch ◽  
Yvonne Naegelin ◽  
Johannes Gregori ◽  
...  
Keyword(s):  
White Matter ◽  
Disease Duration ◽  
Arterial Spin Labelling ◽  
Coefficient Of Determination ◽  
Lesion Volume ◽  
Single Shot ◽  
Lesion Load ◽  
Imaging Characteristics ◽  
Cortical Perfusion ◽  
Spin Labelling

Background: We hypothesized that in multiple sclerosis (MS) patients, reduced cortical perfusion is associated with chronic white matter injury. Objective: To investigate the influence of different clinical and magnetic resonance imaging characteristics on cortical perfusion. Methods: Cerebral blood flow (CBF) was assessed by applying a pulsed arterial spin labelling (ASL) technique combined with single-shot 3D-GRASE (gradient-spin echo) in a cohort of 165 MS patients with a relapsing–remitting ( n=123) or secondary progressive disease course ( n=42). Mean age was 45.4 years (20–68 years), mean disease duration was 14.2 years (1–48 years). Results: Mean cortical CBF was 45.6 ml/100g per min (SD: 7.8 ml/100g per min). Stepwise multiple linear regression models were calculated to investigate the relationship between different factor sets and mean CBF. The model with the highest adjusted coefficient of determination included T2 lesion load, age, gender and disease duration as significant factors. Post-hoc Spearman rank correlation revealed significant correlation of adjusted CBF with T2 lesion load (t=−0.35, p=1*10–6), with age (t =−0.34, p=4*10–6), and with disease duration (t=0.16, p=0.03), while Expanded Disability Status Scale (EDSS) did not reach significance in either model. Conclusion: This study suggests that the amount of white matter lesions indicates a reduced metabolic demand and reduced perfusion at a cortical level.

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