X-Y chromosome dissociation in mouse strains difering in efficiency of spermatogenesis: Elevated frequency of univalents in pubertal males

1989 ◽  
Vol 23 (3) ◽  
pp. 357-365 ◽  
Author(s):  
Halina Krzanowska
Keyword(s):  
Y Chromosome ◽  
Mouse Strains ◽  
Elevated Frequency

Segregation analysis of the testis-determining autosomal trait, Tda, that differs between the C57BL/6J and DBA/2J mouse strains suggests a multigenic threshold model

Genome ◽  
1996 ◽  
Vol 39 (2) ◽  
pp. 322-335 ◽  
Author(s):  
James R. Eisner ◽  
Brenda A. Eales ◽  
Fred G. Biddle
Keyword(s):  
Y Chromosome ◽  
Segregation Analysis ◽  
Threshold Model ◽  
Single Gene ◽  
Mouse Strains ◽  
Gene Model ◽  
Backcross Generation ◽  
Testis Development ◽  
Consomic Strain ◽  
Strain Background

The testis-determining autosomal trait (Tda) of the mouse was uncovered when the Y chromosome of the poschiavinus variety of Mus musculus domesticus was introduced into the C57BL/6J laboratory strain background. Testis development is normal in the F1 generation but, in the backcross and subsequent crosses to C57BL/6J females, XY individuals with the poschiavinus Y chromosome expressed bilateral ovaries or various combinations of an ovotestis with a contralateral ovary or testis or bilateral ovotestes and few had testes bilaterally. In other strain backgrounds, such as DBA/2J, XY individuals with the poschiavinus Y chromosome always expressed normal testes bilaterally. The first breeding analysis of this difference in the interaction of strain background with the poschiavinus Y chromosome suggested that the Tda trait was due to a single gene, but attempts to map it failed. We constructed two strains of C57BL/6J and DBA/2J that are consomic for the poschiavinus Y chromosome in order to conduct a segregation analysis of the Tda trait. In the C57BL/6J.Y-POS consomic strain, liability to express incomplete testis development is normally distributed and thresholds in development specify the probability of different classes of ovary, ovotestis, and testis combinations. Testis development is complete in the DBA/2J.Y-POS consomic strain. We demonstrated previously that the Tda trait of C57BL/6J is recessive to that of DBA/2J and the segregating first backcross generation of embryos rejected the single-gene model. We have extended our analysis to a F2 generation of embryos that also rejects a single-gene model. We also report a test mating analysis of the first backcross generation. It was initiated to provide an independent assessment of the single-gene model, but the analysis of the distribution of test mating results suggests that the difference in the Tda trait between C57BL/6J and DBA/2J may be due to a small number of loci, possibly four or five, and that the phenotypic effect between loci may be additive. Key words : mouse, Y chromosome, gonadal hermaphrodites, primary sex determination, autosomal testis-determining genes, multigenic threshold model.

Hippocampal morphology in the inbred mouse strains NZB and CBA/H and their reciprocal congenics for the nonpseudoautosomal region of the Y chromosome

1996 ◽  
Vol 26 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Pascale-Valérie Guillot ◽  
Frans Sluyter ◽  
Abdelkader Laghmouch ◽  
Pierre L. Roubertoux ◽  
Wim E. Crusio
Keyword(s):  
Y Chromosome ◽  
Inbred Mouse ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
Hippocampal Morphology

Most classical Mus musculus domesticus laboratory mouse strains carry a Mus musculus musculus Y chromosome

Nature ◽  
1985 ◽  
Vol 315 (6014) ◽  
pp. 70-72 ◽  
Author(s):  
C. E. Bishop ◽  
P. Boursot ◽  
B. Baron ◽  
F. Bonhomme ◽  
D. Hatat
Keyword(s):  
Y Chromosome ◽  
Mus Musculus ◽  
Laboratory Mouse ◽  
Mouse Strains ◽  
Mus Musculus Domesticus ◽  
Mus Musculus Musculus

The genetic basis of XX-XY differences present before gonadal sex differentiation in the mouse

1995 ◽  
Vol 350 (1333) ◽  
pp. 253-261 ◽  
Keyword(s):  
Y Chromosome ◽  
Genetic Basis ◽  
Sex Differentiation ◽  
Blastocyst Stage ◽  
Mouse Strains ◽  
Developmental Difference ◽  
X Chromosomes ◽  
Chromosomal Genes ◽  
The Difference ◽  
Advanced Development

There is now a substantial body of data showing that in eutherian mammals (mouse, rat, cow and man) XY conceptuses are developmentally more advanced (and consequently larger) than XX conceptuses of equivalent gestational age. This developmental difference is already discernible in the preimplantation period and it has been suggested that the more advanced development of XY embryos may be a consequence of the preimplantation expression of Y chromosomal genes such as Sry or Zfy . In the present paper sex-chromosomally variant mice were used to analyse the genetic basis of XX-XY differences as manifest at 10.5 days post coitum . The results show that the XX-XY difference is due to a combination of a Y chromosome effect and an effect of the difference in X chromosome constitution (2X v IX). The Y effect is not dependent on the presence of Sry . In the light of this and other studies, it is concluded that the Y chromosome of most mouse strains carries a factor which accelerates preimplantation development and that the resulting developmental advantage is carried over into the postimplantation period. The retarding effect of two X chromosomes is then superimposed on this Y effect subsequent to the blastocyst stage but prior to 9.5 days post coitum .

scholarly journals Male-Offspring-Specific, Haplotype-Dependent, Nonrandom Cosegregation of Alleles at Loci on Two Mouse Chromosomes

Genetics ◽  
2000 ◽  
Vol 154 (1) ◽  
pp. 351-356 ◽  
Author(s):  
Fernando Pardo-Manuel de Villena ◽  
Elena de la Casa-Esperón ◽  
Tammi L Briscoe ◽  
Jan-Michel Malette ◽  
Carmen Sapienza
Keyword(s):  
Y Chromosome ◽  
Inbred Mouse ◽  
Female Offspring ◽  
Male Offspring ◽  
Transmission Ratio Distortion ◽  
Transmission Ratio ◽  
Mouse Strains ◽  
Chromosome 11 ◽  
Ratio Distortion ◽  
Specific Haplotype

AbstractF1 backcrosses involving the DDK and C57BL/6 inbred mouse strains show transmission ratio distortion at loci on two different chromosomes, 11 and X. Transmission ratio distortion on chromosome X is restricted to female offspring while that on chromosome 11 is present in offspring of both sexes. In this article we investigate whether the inheritance of alleles at loci on one chromosome is independent of inheritance of alleles on the other. A strong nonrandom association between the inheritance of alleles at loci on both chromosomes is found among male offspring, while independent assortment occurs among female offspring. We also provide evidence that the mechanism by which this phenomenon occurs involves preferential cosegregation of nonparental chromatids of both chromosomes at the second meiotic divison, after the ova has been fertilized by a C57BL/6 sperm bearing a Y chromosome. These observations confirm the influence of the sperm in the segregation of chromatids during female meiosis, and indicate that a locus or loci on the Y chromosome are involved in this instance of meiotic drive.

Y-chromosome length in sublines of two mouse strains

1981 ◽  
Vol 11 (4) ◽  
pp. 359-368 ◽  
Author(s):  
Benson E. Ginsburg ◽  
Lynne C. Vigue ◽  
William A. Larson ◽  
Stephen C. Maxson
Keyword(s):  
Y Chromosome ◽  
Chromosome Length ◽  
Mouse Strains

Alterations in the number of motoneurons containing immunoreactive calcitonin gene-related peptide(CGRP)& choline acetyltransferase(ChAT) in the cervical spinal cord of the wobbler mouse during the development of the motoneuron disease

1995 ◽  
Vol 53 ◽  
pp. 970-971
Author(s):  
L. Vacca-Galloway ◽  
Y.Q. Zhang ◽  
P. Bose ◽  
S.H. Zhang
Keyword(s):  
Spinal Cord ◽  
Early Stage ◽  
Cervical Spinal Cord ◽  
Wild Type Mouse ◽  
Reflex Response ◽  
Mouse Strains ◽  
Behavioral Tests ◽  
Wobbler Mouse ◽  
Stage 4 ◽  
Stage 1

The Wobbler mouse (wr) has been studied as a model for inherited human motoneuron diseases (MNDs). Using behavioral tests for forelimb power, walking, climbing, and the “clasp-like reflex” response, the progress of the MND can be categorized into early (Stage 1, age 21 days) and late (Stage 4, age 3 months) stages. Age-and sex-matched normal phenotype littermates (NFR/wr) were used as controls (Stage 0), as well as mice from two related wild-type mouse strains: NFR/N and a C57BI/6N. Using behavioral tests, we also detected pre-symptomatic Wobblers at postnatal ages 7 and 14 days. The mice were anesthetized and perfusion-fixed for immunocytochemical (ICC) of CGRP and ChAT in the spinal cord (C3 to C5).Using computerized morphomety (Vidas, Zeiss), the numbers of IR-CGRP labelled motoneurons were significantly lower in 14 day old Wobbler specimens compared with the controls (Fig. 1). The same trend was observed at 21 days (Stage 1) and 3 months (Stage 4). The IR-CGRP-containing motoneurons in the Wobbler specimens declined progressively with age.

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