A successfully treated case of multicentric angiofollicular hyperplasia with oral chemotherapy (Castleman's disease)

1990 ◽  
Vol 18 (4) ◽  
pp. 333-335 ◽  
Author(s):  
Nicholas A. Pavlidis ◽  
Fotini N. Skopouli ◽  
Mary C. Bai ◽  
Constantinos L. Bourantas
Keyword(s):  
Castleman’S Disease ◽  
Oral Chemotherapy ◽  
Castleman's Disease ◽  
Angiofollicular Hyperplasia

Unicentric angiofollicular hyperplasia (Castleman's disease) of the parotid

1996 ◽  
Vol 81 (3) ◽  
pp. 328-332 ◽  
Author(s):  
Pietro Leocata ◽  
Alfonso Corbacelli ◽  
Alessandro Chiominto ◽  
Tommaso Cutilli ◽  
Laura Belli ◽  
...  
Keyword(s):  
Castleman’S Disease ◽  
Castleman's Disease ◽  
Angiofollicular Hyperplasia

scholarly journals A Rare Coexistence of Retroperitoneal Pararenal Castleman's Disease with Focal Nodular Hyperplasia

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Theodosios Theodosopoulos ◽  
Andreas Karakatsanis ◽  
Anneza I. Yiallourou ◽  
Fotios Nikolakopoulos ◽  
Vassiliki Psychogiou ◽  
...  
Keyword(s):  
Focal Nodular Hyperplasia ◽  
Castleman’S Disease ◽  
Surgical Excision ◽  
Left Lobe ◽  
Hepatic Lesion ◽  
Left Renal Artery ◽  
Castleman's Disease ◽  
Vascular Type ◽  
Nodular Hyperplasia ◽  
Angiofollicular Hyperplasia

Castleman's disease is a distinct form of lymph node hyperplasia divided into a solitary and a multicentric type. The solitary type occurs most commonly in the mediastinum and is usually asymptomatic. We present a patient with Castleman's disease of the hyaline-vascular solitary type located in the retroperitoneum. The patient was a 38-year-old male, who presented to our hospital with fever. The imaging workup revealed a retroperitoneal mass, measuring 4 × 6 cm, located lateral to the aorta, inferior to the left renal artery and vein, and posterior to the left testicular vein. At workup, a solid hepatic lesion, 3 cm in diameter, located in the left lobe of the liver, segment IV, was also identified. Both lesions were surgically excised. The retroperitoneal tumor had the features of angiofollicular hyperplasia (Castleman's disease), hyaline-vascular type, whereas a diagnosis of focal nodular hyperplasia was made for the hepatic lesion. The patient is well at fourty months followup postoperatively. Surgical excision is the treatment of choice for unifocal Castleman's disease.

An Extra Ordinary Respone of Castleman’s Disease to Rituximab.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 3849-3849 ◽  
Author(s):  
Sherif Abdou ◽  
Hayman Salib
Keyword(s):  
Mediastinal Lymph Node ◽  
Castleman’S Disease ◽  
Lymph Node Biopsy ◽  
Hiv Positive ◽  
Chronic Glomerulonephritis ◽  
Castleman's Disease ◽  
Bilateral Hilar Lymphadenopathy ◽  
Fatal Course ◽  
Angiofollicular Hyperplasia

Abstract Castleman’s disease is a very rare non-neoplastic lymphoproliferative disorder of unknown cause that is diagnosed on a pathological basis. It is often associated with autoimmune diseases, and diagnosed in the context of human immunodeficiency virus (HIV) positive patients. No standard treatment has been developed for this rare disease. CASE REPORT: This 54-year-old male presented with nausea and vomiting. He has a past medical history of hypertension and chronic glomerulonephritis. His laboratory results showed acute renal failure. Hemodialysis was started prior to further work up. A chest x-ray showed bilateral hilar lymphadenopathy that was later confirmed by computerized tomography (CT) of the chest. A mediastinoscopy and mediastinotomy were performed. Mediastinal lymph node biopsy showed findings consistent with Castleman’s disease including atrophic follicles with hyalinized vessels. Remission was obtained for one year by prednisone and cyclophosphamide, but the patient relapsed with multiple lymphadenopathy. Biopsy confirmed the recurrence of Castleman’s disease. Rituximab was added to cyclophosphamide as a treatment regimen and for more than two years the patient has done extremely well. His kidney function returned to his baseline, hemodialysis was stopped, and the patient has long-term remission on CT scan and postron emission tomography (PET). DISCUSSION: Castleman’s disease is lymphadenopathy of unknown cause. About 400 patients have been reported to date. It is diagnosed microscopically by lymphadenopathy with angiofollicular hyperplasia and plasma cell infiltration. It has a rapid progressive and often fatal course. Traditional treatment is chemotherapy. A new trend in the treatment of Castleman’s disease is Rituximab which is a monoclonal antibody that showed success in HIV positive patients with Castleman’s disease. We believe that this is the first reported case of long-term remission of Castleman’s disease in an HIV-negative patient treated with Rituximab and chemotherapy.

Castleman's Disease Masquerading as Sigmoid Colon Tumor and Hodgkin Lymphoma

Swiss Surgery ◽  
2002 ◽  
Vol 8 (1) ◽  
pp. 7-10 ◽  
Author(s):  
Altinli ◽  
Pekmezci ◽  
Balkan ◽  
Somay ◽  
M. Akif Buyukbese ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Hodgkin Lymphoma ◽  
Sigmoid Colon ◽  
Castleman’S Disease ◽  
Malignant Potential ◽  
Colon Tumor ◽  
Rare Entity ◽  
Castleman's Disease ◽  
Mediastinal Lymph Nodes ◽  
Histologic Types

Castleman's disease is a benign lymphoid neoplasm first reported as hyperplasia of mediastinal lymph nodes. Some authors referred to the lesions as isolated tumors, described as a variant of Hodgkin's disease with a possibility of a malignant potential and others proposed that the lymphoid masses were of a hamartomatous nature. Three histologic variants and two clinical types of the disease have been described. The disease may occur in almost any area in which lymph nodes are normally found. The most common locations are thorax (63%), abdomen (11%) and axilla (4%). We report two separate histologic types of Castleman's disease which were rare in the literature, mimicking sigmoid colon tumor and Hodgkin lymphoma. The diagnostic and therapeutic aspects of this rare entity is discussed.

A Case of Spontaneous Resolution of Castleman's Disease in the Neck

2012 ◽  
Vol 55 (11) ◽  
pp. 736
Author(s):  
Seong-Hyun Yun ◽  
Soo-Ryang Chae ◽  
Dong-Joon Yoo ◽  
Young-Hoon Joo
Keyword(s):  
Castleman’S Disease ◽  
Spontaneous Resolution ◽  
Castleman's Disease

A Case of Castleman’s Disease of the Neck

2019 ◽  
Vol 70 (4) ◽  
pp. 290-297
Author(s):  
Yukiomi Kushihashi ◽  
Shunya Egawa ◽  
Tatsuya Kitajima ◽  
Hitome Kobayashi ◽  
Toshikazu Shimane
Keyword(s):  
Castleman’S Disease ◽  
Castleman's Disease

Thoracoscopic resection for Castleman's disease in the chest wall; A case report.

1999 ◽  
Vol 13 (1) ◽  
pp. 72-76
Author(s):  
Yoshinori Suzuki ◽  
Yoshiaki Narita ◽  
Kyosuke Miyazaki ◽  
Yo Kurashima ◽  
Toru Nakamura ◽  
...  
Keyword(s):  
Case Report ◽  
Chest Wall ◽  
Castleman’S Disease ◽  
Castleman's Disease ◽  
Thoracoscopic Resection
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