scholarly journals A Rare Coexistence of Retroperitoneal Pararenal Castleman's Disease with Focal Nodular Hyperplasia

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Theodosios Theodosopoulos ◽  
Andreas Karakatsanis ◽  
Anneza I. Yiallourou ◽  
Fotios Nikolakopoulos ◽  
Vassiliki Psychogiou ◽  
...  
Keyword(s):  
Focal Nodular Hyperplasia ◽  
Castleman’S Disease ◽  
Surgical Excision ◽  
Left Lobe ◽  
Hepatic Lesion ◽  
Left Renal Artery ◽  
Castleman's Disease ◽  
Vascular Type ◽  
Nodular Hyperplasia ◽  
Angiofollicular Hyperplasia

Castleman's disease is a distinct form of lymph node hyperplasia divided into a solitary and a multicentric type. The solitary type occurs most commonly in the mediastinum and is usually asymptomatic. We present a patient with Castleman's disease of the hyaline-vascular solitary type located in the retroperitoneum. The patient was a 38-year-old male, who presented to our hospital with fever. The imaging workup revealed a retroperitoneal mass, measuring 4 × 6 cm, located lateral to the aorta, inferior to the left renal artery and vein, and posterior to the left testicular vein. At workup, a solid hepatic lesion, 3 cm in diameter, located in the left lobe of the liver, segment IV, was also identified. Both lesions were surgically excised. The retroperitoneal tumor had the features of angiofollicular hyperplasia (Castleman's disease), hyaline-vascular type, whereas a diagnosis of focal nodular hyperplasia was made for the hepatic lesion. The patient is well at fourty months followup postoperatively. Surgical excision is the treatment of choice for unifocal Castleman's disease.

scholarly journals Localized Castleman’s Disease in Retroperitoneum Mimicking Broad Ligament Leiomyoma – a Diagnostic Challenge

2016 ◽  
Vol 10 (2) ◽  
pp. 57-59
Author(s):  
S Gon ◽  
D Mallik ◽  
A Bhattacharya ◽  
B Majumdar ◽  
M Sengupta
Keyword(s):  
Broad Ligament ◽  
Castleman’S Disease ◽  
Surgical Excision ◽  
Young Female ◽  
Castleman Disease ◽  
Castleman's Disease ◽  
Diagnostic Challenge ◽  
Diagnostic Dilemma ◽  
Vascular Type ◽  
Complete Surgical Excision

Primary retroperitoneal tumours pose a diagnostic dilemma and therapeutic challenges because of their location and late detection. Localized Castleman Disease (CD) in retroperitoneal location is a rare occurrence, with incidence of only 4% cases occurring in diverse locations like retroperitoneum. A rare case of unicentric localized Castleman Disease localized in broad ligament is hereby reported which was clinically & radiologically suspected as broad ligament leiomyoma but finally diagnosed as Castleman’s Disease, hyaline vascular type in a young female posing a diagnostic challenge both for the pathologist and clinician. Definite diagnosis is essential as complete surgical excision in case of unicentric Castleman’s Disease has good prognosis after resection.   

Castleman’s Disease: Four Extraordinary Presantations and Review of Literature.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 4416-4416
Author(s):  
Gokben Yildirim Kupesiz ◽  
Bahar Akkaya ◽  
O. Alphan Kupesiz ◽  
Gulten Karpuzoglu
Keyword(s):  
Castleman’S Disease ◽  
Surgical Excision ◽  
Good Prognosis ◽  
Castleman's Disease ◽  
Cancer History ◽  
Systemic Involvement ◽  
Vascular Type ◽  
Histological Variants ◽  
Clinical Disorders ◽  
Localized Disease

Abstract Castleman’s disease is a rare disorder of the lymphoid tissue with three possible histological variants--the hyalin-vascular type, with a good prognosis, the plasma-cellular type and the mixed type; the latter two are both more aggressive than the hyalin-vascular type. Two clinical types of this disease have already been described: the localized or unifocal type and the multicentric or multifocal type. Localized and multicentric Castleman’s disease may be different clinical disorders with overlapping histologic features. Localized disease generally presented with a single enlarged lymph node or widening of the mediastinum, whereas multicentric disease is a systemic lymphoproliferative disorder characterized by lymphadenopathy, hepatosplenomegaly, constitutional symptoms, anemia, hypoalbuminemia, and hypergammaglobulinemia. Unlike the localized type, for which surgical excision is curative regardless of the histologic type, multicentric disease often necessitates aggressive systemic therapy and portends a poorer outcome. The aetiology of Castleman’s disease remains unclear. Here, we report four cases of Castleman’s disease, with extraordinary presentations. Tumors from retroperitoneum, mesenterium, bladder vicinity and nasopharenx locations were included. All of patients were taken to the surgery with different pre operative diagnosis. There were 1 female and 3 males; ages ranged from 16–62 years old; sizes ranged from 4– 9 cm (mean 5.5 cm). All patients presented with localized disease. One of the patients had previous NHL and lung cancer history. None of the patients demonstrated systemic involvement or signs of the POEMS syndrome. Hystopathologically 3 of the cases were classified as hyalin-vascular type and 1 of the cases were classified as plasma-cellular type. None of the patients had recurrences. Castleman ‘s disease is an uncommon cause of lymphadenopathy, and must be considered after all other causes have been eliminated. We also add the overview of the literature of the cases with extraordinary presentations.

Castleman's disease of the leptomeninges

1988 ◽  
Vol 69 (2) ◽  
pp. 283-286 ◽  
Author(s):  
Gregory S. Severson ◽  
Douglas S. Harrington ◽  
Dennis D. Weisenburger ◽  
Rodney D. McComb ◽  
John H. Casey ◽  
...  
Keyword(s):  
Plasma Cells ◽  
Castleman’S Disease ◽  
Surgical Excision ◽  
Castleman's Disease ◽  
Content Type ◽  
Generalized Seizures ◽  
Vascular Type ◽  
Hyaline Vascular Type ◽  
Variable Extent ◽  
Operative Findings

✓ Castleman's disease is a rare, benign lymphoproliferative disorder that usually arises in lymph nodes, most commonly in the mediastinum. The authors report the clinical and pathological features of three patients with localized Castleman's disease of the leptomeninges. There were two women, aged 63 and 82 years, and one 25-year-old man. Two patients had progressive focal motor seizures of 3 and 24 months' duration, and the third patient presented acutely with generalized seizures. The clinical diagnosis was meningioma in each case, based on computerized tomography scans, cerebral arteriography, and the operative findings. All three lesions arose in the leptomeninges, compressed the underlying cerebral cortex, and infiltrated the overlying dura to a variable extent. Surgical excision of the tumor resulted in marked clinical improvement in all three patients. Histologically, two cases were classified as the hyaline-vascular type and one as the plasma cell type. Immunohistochemical stains of the latter case revealed a monoclonal population of mature plasma cells. Only a few scattered polyclonal plasma cells were seen in the other two cases. The authors conclude that Castleman's disease involving the leptomeninges is a rare disorder that may mimic meningioma clinically and radiographically.

scholarly journals Unicentric Castleman’s Disease in a Man Originally Diagnosed with Sarcoidosis: A Case and Analysis of the Key Differences in Diagnosis

2019 ◽  
Vol 4 (4) ◽  
Keyword(s):  
Lymph Nodes ◽  
Surgical Resection ◽  
Lymphoproliferative Disorder ◽  
Castleman’S Disease ◽  
Castleman Disease ◽  
Castleman's Disease ◽  
Vascular Type ◽  
Hyaline Vascular Type ◽  
Complete Surgical Resection ◽  
Vascular Proliferation

Castleman Disease (CD) is a lymphoproliferative disorder characterized by enlarged hyperplastic lymph nodes with regressed follicles surrounded by expanded mantle zones of small lymphocytes, and interfollicular vascular proliferation in the hyaline-vascular type. There are two types: unicentric and multicentric. Unicentric, hyalinevascular type of Castleman’s disease can be treated successfully with complete surgical resection with monitoring for reoccurrence. Here we report a case of a patient originally diagnosed with sarcoidosis who was found to have Unicentric Castleman’s disease.

scholarly journals Castleman’s disease: an entity forgotten in ENT

2021 ◽  
Vol 7 (5) ◽  
pp. 905
Author(s):  
Mohamed Riyas Ali ◽  
Vikram Wadhwa ◽  
Ravi Meher ◽  
Reena Tomar ◽  
Karishma Singh ◽  
...  
Keyword(s):  
Castleman’S Disease ◽  
Treatment Modalities ◽  
Retropharyngeal Space ◽  
Castleman's Disease ◽  
Complete Excision ◽  
Vascular Type ◽  
Hyaline Vascular Type ◽  
Systemic Lymphadenopathy ◽  
Rare Site ◽  
Usual Site

<p class="abstract">Castleman’s disease (CD) usually presents as localized or systemic lymphadenopathy or as an extra nodal mass. The usual site of presentation are mediastinum, retroperitoneum, axilla and mesentery. Only 3 cases of CD have been reported in retro pharyngeal space. We report a case of 20 year old male patient with retropharyngeal mass. He presented with difficulty in swallowing, change in voice and respiratory distress. The mass was removed in-toto transorally after performing elective tracheostomy. The histopathological findings were consistent with hyaline vascular type of CD. He was decannulated after two day and postoperative period was uneventful. Postoperative CT imaging confirmed the complete excision of tumor and patient is on follow up, with no signs of recurrence. The presentation of tumour in the retropharyngeal space which is a rare site of occurrence add to the uniqueness of this case. Unicentric CD has an excellent prognosis and surgery is the management of choice. Its clinical features, histological subtypes, treatment modalities and prognosis are discussed.</p>

scholarly journals Successful Treatment of Mediastinal Unicentric Castleman’s Disease Using Video-Assisted Thoracoscopic Surgery with Preoperative Embolization

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Yosuke Amano ◽  
Daiya Takai ◽  
Nobuya Ohishi ◽  
Aya Shinozaki-Ushiku ◽  
Masashi Fukayama ◽  
...  
Keyword(s):  
Thoracoscopic Surgery ◽  
Castleman’S Disease ◽  
Preoperative Embolization ◽  
Castleman's Disease ◽  
Tumor Vascularity ◽  
Mediastinal Tumors ◽  
Video Assisted ◽  
Vascular Type ◽  
Hyaline Vascular Type ◽  
Video Assisted Thoracoscopic Surgery

Unicentric Castleman’s disease is a rare, benign lymphoproliferative disorder that is curable with surgical resection. However, significant bleeding often occurs during surgery because of tumor hypervascularity. We herein present a case of hyaline-vascular-type mediastinal unicentric Castleman’s disease, successfully resected using video-assisted thoracoscopic surgery with preoperative embolization. In the present case, tumor hypervascularity and feeding vessels were revealed by computed tomography (CT), which led us to perform preoperative angiography and embolization to the tumor feeding arteries to reduce intraoperative bleeding. Castleman’s disease should be considered in the differential diagnosis of hypervascular mediastinal tumors. Tumor vascularity should be assessed prior to surgery, and preoperative embolization should be considered.

scholarly journals Retroperitoneal pararenal castleman’s disease: a case report

2013 ◽  
Vol 3 (6) ◽  
pp. 509-511
Author(s):  
S Shrestha ◽  
U Nepal ◽  
N Lamichhane ◽  
P Chhetri
Keyword(s):  
Preoperative Diagnosis ◽  
Histopathological Examination ◽  
Castleman’S Disease ◽  
Accurate Diagnosis ◽  
Renal Tumors ◽  
Unknown Etiology ◽  
Resected Specimen ◽  
Castleman's Disease ◽  
Vascular Type ◽  
Hyaline Vascular Type

Castleman’s diseas is a rare lymphoproliferative disorder of unknown etiology. We report a 28 years old woman with solitary Castleman’s disease in the left pararenal space. This case was diagnosed preoperatively as renal cell carcinoma. The patient underwent a radical nephrectomy with dissection of pararenal mass. Histopathological examination of the surgically resected specimen showed the hyaline vascular type of Castleman’s disease. A preoperative diagnosis of Castleman’s disease is difficult; therefore, a surgical resection and histopathological evaluation can provide an accurate diagnosis of tumor. Taking this case into consideration, we suggest that Castleman’s disease should be included in the differential diagnosis of renal tumors. DOI: http://dx.doi.org/10.3126/jpn.v3i6.9004 Journal of Pathology of Nepal (2013) Vol. 3, 509-511

Rare case of the hyaline vascular type of Castleman's disease of the kidney

2007 ◽  
Vol 14 (12) ◽  
pp. 1098-1100 ◽  
Author(s):  
Koji. Hatano ◽  
Shigeki Fujita ◽  
Yuichi Tsujimoto ◽  
Tsuyoshi Takada ◽  
Masato Honda ◽  
...  
Keyword(s):  
Rare Case ◽  
Castleman’S Disease ◽  
Castleman's Disease ◽  
Vascular Type ◽  
Hyaline Vascular Type
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