Multidisciplinary treatment of metastatic germ cell tumor: Clinical summary and discussion

1989 ◽  
Vol 17 (3) ◽  
pp. 179-180 ◽  
Author(s):  
Jon Pritchard ◽  
C. Ross Pinkerton
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Multidisciplinary Treatment ◽  
Cell Tumor

Multiple Tumor-Associated Intracranial Aneurysms Adjacent to a Suprasellar Germ Cell Tumor: Case Report and Review of Literature

2021 ◽  
pp. 1-10
Author(s):  
John K. Yue ◽  
Diana Chang ◽  
Taemin Oh ◽  
Ethan A. Winkler ◽  
Alex Y. Lu ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Intracranial Aneurysms ◽  
Multidisciplinary Treatment ◽  
Clinical History ◽  
Cell Tumor ◽  
Paracrine Signaling ◽  
Current Case ◽  
Case Presentation ◽  
Multiple Tumor

<b><i>Introduction:</i></b> Tumor-associated intracranial aneurysms are rare and not well understood. <b><i>Case Presentation:</i></b> We describe a 4-year-old female with multiple intracranial aneurysms intimately associated with a suprasellar germ cell tumor (GCT). We provide the clinical history, medical, and surgical treatment course, as well as a comprehensive and concise synthesis of the literature on tumor-associated aneurysms. <b><i>Discussion:</i></b> We discuss mechanisms for aneurysm formation with relevance to the current case, including cellular and paracrine signaling pertinent to suprasellar GCTs and possible molecular pathways involved. We review the complex multidisciplinary treatment required for complex tumor and cerebrovascular interactions.

scholarly journals Leptomeningeal Metastases in a Patient with an Extragonadal Germ Cell Tumor

2008 ◽  
Vol 2 ◽  
pp. CMO.S687
Author(s):  
Yoshiaki Kinebuchi ◽  
Masakuni Ishikawa ◽  
Osamu Ishizuka ◽  
Osamu Nishizawa ◽  
Kazuhiro Hongo
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Multidisciplinary Treatment ◽  
Germ Cell Tumors ◽  
Whole Brain Radiotherapy ◽  
Salvage Chemotherapy ◽  
Leptomeningeal Metastases ◽  
Cell Tumor ◽  
Extragonadal Germ Cell Tumor ◽  
Brain Radiotherapy

We present a case of leptomeningeal metastases in a 30-year-old man with an extragonadal germ cell tumor. The patient was referred to our hospital for treatment of an occipital brain metastasis. This lesion was resected, followed by whole brain radiotherapy and further chemotherapy, and a temporary complete remission was achieved. However, leptomeningeal recurrence developed, and despite salvage chemotherapy, the patient died of disease. Although multidisciplinary treatment is given to treat brain metastases of germ cell tumors, the patients’ prognosis has been unsatisfactory. The identification of a standard/effective treatment is required.

Multidisciplinary treatment of metastatic germ cell tumor clinical summary and discussion

1987 ◽  
Vol 15 (5) ◽  
pp. 257-261 ◽  
Author(s):  
Giulio J. D'Angio ◽  
Audrey E. Evans ◽  
Michael Willoughby
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Multidisciplinary Treatment ◽  
Cell Tumor

Cisplatin and Etoposide in Childhood Germ Cell Tumor: Brazilian Pediatric Oncology Society Protocol GCT-91

2009 ◽  
Vol 27 (8) ◽  
pp. 1297-1303 ◽  
Author(s):  
Luiz Fernando Lopes ◽  
Carla Renata Pacheco Macedo ◽  
Elitânia Marinho Pontes ◽  
Simone dos Santos Aguiar ◽  
Maria José Mastellaro ◽  
...  
Keyword(s):  
High Risk ◽  
Germ Cell ◽  
Children And Adolescents ◽  
Germ Cell Tumor ◽  
Multidisciplinary Treatment ◽  
Germ Cell Tumors ◽  
High Risk Group ◽  
Cell Tumor ◽  
Term Survival ◽  
Risk Patients

Purpose In 1988, we formed a consortium of Brazilian institutions to develop uniform standards for the diagnostic assessment and multidisciplinary treatment of children and adolescents with germ cell tumors. We also implemented the first childhood Brazilian germ cell tumor protocol, GCT-91, evaluating two-agent chemotherapy with cisplatin and etoposide (PE). We now report on the clinical characteristics and survival of children and adolescents with germ cell tumors treated on this protocol. Patients and Methods From May 1991 to April 2000, 115 patients (106 assessable patients) were enrolled onto the Brazilian protocol with a diagnosis of germ cell tumor. Results Patients were treated with surgery only (n = 35) and chemotherapy (n = 71). Important prognostic factors included stage (P = .025), surgical procedure at diagnosis according to resectability (P < .032), and abnormal lactate dehydrogenase value at diagnosis (P < .001). Conclusion The improvement in survival by the introduction of a standard protocol is an important achievement. This is of particular importance for smaller institutions with previous limited experience in the treatment of childhood germ cell tumors. In addition, the results of a two-agent regimen with PE were favorable (5-year overall survival rate is 83.3% for patients in the high-risk group [n = 36] who received PE v 58.8% for patients in the high-risk patients group who received PE plus ifosfamide, vinblastine, and bleomycin [n = 17; P = .017]). Thus for selected patients, complex three-agent regimens may not be necessary to achieve long-term survival, even for some patients with advanced disease.

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