Impact of a spatially dependent dose delivery time structure on the biological effectiveness of scanning proton therapy

2021 ◽  
Author(s):  
Koki Kasamatsu ◽  
Sodai Tanaka ◽  
Koichi Miyazaki ◽  
Seishin Takao ◽  
Naoki Miyamoto ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Time Structure ◽  
Delivery Time ◽  
Dose Delivery ◽  
Biological Effectiveness

Effects of Dose-Delivery Time Structure on Biological Effectiveness for Therapeutic Carbon-Ion Beams Evaluated with Microdosimetric Kinetic Model

2013 ◽  
Vol 180 (1) ◽  
pp. 44-59 ◽  
Author(s):  
Taku Inaniwa ◽  
Masao Suzuki ◽  
Takuji Furukawa ◽  
Yuki Kase ◽  
Nobuyuki Kanematsu ◽  
...  
Keyword(s):  
Kinetic Model ◽  
Ion Beams ◽  
Time Structure ◽  
Delivery Time ◽  
Dose Delivery ◽  
Carbon Ion ◽  
Biological Effectiveness

The impact of dose delivery time on biological effectiveness in proton irradiation with various biological parameters

2020 ◽  
Vol 47 (9) ◽  
pp. 4644-4655
Author(s):  
Koki Kasamatsu ◽  
Taeko Matsuura ◽  
Sodai Tanaka ◽  
Seishin Takao ◽  
Naoki Miyamoto ◽  
...  
Keyword(s):  
Proton Irradiation ◽  
Biological Parameters ◽  
Delivery Time ◽  
Dose Delivery ◽  
Biological Effectiveness ◽  
The Impact

scholarly journals A MC tool for CT-based calculations of dose delivery and activation in proton therapy

2007 ◽  
Vol 74 ◽  
pp. 021013 ◽  
Author(s):  
K Parodi ◽  
A Ferrari ◽  
F Sommerer ◽  
H Paganetti
Keyword(s):  
Proton Therapy ◽  
Dose Delivery

scholarly journals Metallic Nanoparticles: A Useful Prompt Gamma Emitter for Range Monitoring in Proton Therapy?

Radiation ◽  
2021 ◽  
Vol 1 (4) ◽  
pp. 305-316
Author(s):  
Sébastien Penninckx ◽  
Félicien Hespeels ◽  
Julien Smeets ◽  
Julien L. Colaux ◽  
Stéphane Lucas ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Metallic Nanoparticles ◽  
Target Volume ◽  
Prompt Gamma ◽  
Dose Delivery ◽  
Non Invasive ◽  
Safety Margins ◽  
Medical Physicists ◽  
Invasive Techniques ◽  
Therapy Treatment

In clinical practice, dose delivery in proton therapy treatment is affected by uncertainties related to the range of the beam in the patient, which requires medical physicists to introduce safety margins on the penetration depth of the beam. Although this ensures an irradiation of the entire clinical target volume with the prescribed dose, these safety margins also lead to the exposure of nearby healthy tissues and a subsequent risk of side effects. Therefore, non-invasive techniques that allow for margin reduction through online monitoring of prompt gammas emitted along the proton tracks in the patient are currently under development. This study provides the proof-of-concept of metal-based nanoparticles, injected into the tumor, as a prompt gamma enhancer, helping in the beam range verification. It identifies the limitations of this application, suggesting a low feasibility in a realistic clinical scenario but opens some avenues for improvement.

scholarly journals Impact of range uncertainty on clinical distributions of linear energy transfer and biological effectiveness in proton therapy

2020 ◽  
Author(s):  
Christian Hahn ◽  
Jan Eulitz ◽  
Nils Peters ◽  
Patrick Wohlfahrt ◽  
Wolfgang Enghardt ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Proton Therapy ◽  
Linear Energy Transfer ◽  
Biological Effectiveness

scholarly journals Clinically relevant nanodosimetric simulation of DNA damage complexity from photons and protons

RSC Advances ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 6845-6858 ◽  
Author(s):  
N. T. Henthorn ◽  
J. W. Warmenhoven ◽  
M. Sotiropoulos ◽  
A. H. Aitkenhead ◽  
E. A. K. Smith ◽  
...  
Keyword(s):  
Dna Damage ◽  
Monte Carlo ◽  
Monte Carlo Simulations ◽  
Proton Therapy ◽  
Relative Biological Effectiveness ◽  
Biological Effectiveness ◽  
Mechanistic Understanding

Relative Biological Effectiveness (RBE) is a controversial and important topic in proton therapy. This work uses Monte Carlo simulations of DNA damage for protons and photons to probe this phenomenon, providing a plausible mechanistic understanding.

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