scholarly journals Clinically relevant nanodosimetric simulation of DNA damage complexity from photons and protons

RSC Advances ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 6845-6858 ◽  
Author(s):  
N. T. Henthorn ◽  
J. W. Warmenhoven ◽  
M. Sotiropoulos ◽  
A. H. Aitkenhead ◽  
E. A. K. Smith ◽  
...  
Keyword(s):  
Dna Damage ◽  
Monte Carlo ◽  
Monte Carlo Simulations ◽  
Proton Therapy ◽  
Relative Biological Effectiveness ◽  
Biological Effectiveness ◽  
Mechanistic Understanding

Relative Biological Effectiveness (RBE) is a controversial and important topic in proton therapy. This work uses Monte Carlo simulations of DNA damage for protons and photons to probe this phenomenon, providing a plausible mechanistic understanding.

SU-F-T-682: In-Vivo Simulation of the Relative Biological Effectiveness in Proton Therapy Using a Monte Carlo Method

2016 ◽  
Vol 43 (6Part24) ◽  
pp. 3621-3621
Author(s):  
H Oesten ◽  
S Loeck ◽  
S Helmbrecht ◽  
F Tillner ◽  
P Wohlfahrt ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Monte Carlo Method ◽  
Proton Therapy ◽  
Relative Biological Effectiveness ◽  
Biological Effectiveness

scholarly journals EP-1997: Monte Carlo simulations of direct DNA damage on gold nanoparticle enhanced proton therapy

2018 ◽  
Vol 127 ◽  
pp. S1086
Author(s):  
M. Sotiropoulos ◽  
N.T. Henthorn ◽  
J.W. Warmenhoven ◽  
R.I. Mackay ◽  
K.J. Kirkby ◽  
...  
Keyword(s):  
Dna Damage ◽  
Monte Carlo ◽  
Monte Carlo Simulations ◽  
Gold Nanoparticle ◽  
Proton Therapy

scholarly journals Comparative photon and proton dosimetry for patients with mediastinal lymphoma in the era of Monte Carlo treatment planning and variable relative biological effectiveness

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Yolanda D. Tseng ◽  
Shadonna M. Maes ◽  
Gregory Kicska ◽  
Patricia Sponsellor ◽  
Erik Traneus ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Treatment Planning ◽  
Proton Therapy ◽  
Breast Tissue ◽  
Relative Biological Effectiveness ◽  
Planning System ◽  
Treatment Planning System ◽  
Target Coverage ◽  
Mediastinal Lymphoma ◽  
Biological Effectiveness

Abstract Background Existing pencil beam analytical (PBA) algorithms for proton therapy treatment planning are not ideal for sites with heterogeneous tissue density and do not account for the spatial variations in proton relative biological effectiveness (vRBE). Using a commercially available Monte Carlo (MC) treatment planning system, we compared various dosimetric endpoints between proton PBA, proton MC, and photon treatment plans among patients with mediastinal lymphoma. Methods Eight mediastinal lymphoma patients with both free breathing (FB) and deep inspiration breath hold (DIBH) CT simulation scans were analyzed. The original PBA plans were re-calculated with MC. New proton plans that used MC for both optimization and dose calculation with equivalent CTV/ITV coverage were also created. A vRBE model, which uses a published model for DNA double strand break (DSB) induction, was applied on MC plans to study the potential impact of vRBE on cardiac doses. Comparative photon plans were generated on the DIBH scan. Results Re-calculation of FB PBA plans with MC demonstrated significant under coverage of the ITV V99 and V95. Target coverage was recovered by re-optimizing the PT plan with MC with minimal change to OAR doses. Compared to photons with DIBH, MC-optimized FB and DIBH proton plans had significantly lower dose to the mean lung, lung V5, breast tissue, and spinal cord for similar target coverage. Even with application of vRBE in the proton plans, the putative increase in RBE at the end of range did not decrease the dosimetric advantages of proton therapy in cardiac substructures. Conclusions MC should be used for PT treatment planning of mediastinal lymphoma to ensure adequate coverage of target volumes. Our preliminary data suggests that MC-optimized PT plans have better sparing of the lung and breast tissue compared to photons. Also, the potential for end of range RBE effects are unlikely to be large enough to offset the dosimetric advantages of proton therapy in cardiac substructures for mediastinal targets, although these dosimetric findings require validation with late toxicity data.

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