Characterization of an x‐ray tube‐based ultrahigh dose‐rate system for in vitro irradiations

2021 ◽  
Author(s):  
Daniel D. Cecchi ◽  
François Therriault‐Proulx ◽  
Simon Lambert‐Girard ◽  
Alexander Hart ◽  
Andrew Macdonald ◽  
...  
Keyword(s):  
Dose Rate ◽  
Rate System ◽  
X Ray

scholarly journals Synthesis and characterization of novel bioactive 1,2,4-oxadiazole natural product analogs bearing the N-phenylmaleimide and N-phenylsuccinimide moieties

2013 ◽  
Vol 9 ◽  
pp. 2202-2215 ◽  
Author(s):  
Catalin V Maftei ◽  
Elena Fodor ◽  
Peter G Jones ◽  
M Heiko Franz ◽  
Gerhard Kelter ◽  
...  
Keyword(s):  
Natural Product ◽  
Synthesis And Characterization ◽  
Aminobenzoic Acid ◽  
One Pot ◽  
X Ray ◽  
X Ray Crystallography ◽  
Quisqualic Acid ◽  
Oxobutanoic Acid

Taking into consideration the biological activity of the only natural products containing a 1,2,4-oxadiazole ring in their structure (quisqualic acid and phidianidines A and B), the natural product analogs 1-(4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)phenyl)pyrrolidine-2,5-dione (4) and 1-(4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)phenyl)-1H-pyrrole-2,5-dione (7) were synthesized starting from 4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)aniline (1) in two steps by isolating the intermediates 4-(4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)phenylamino)-4-oxobutanoic acid (3) and (Z)-4-(4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)phenylamino)-4-oxobut-2-enoic acid (6). The two natural product analogs 4 and 7 were then tested for antitumor activity toward a panel of 11 cell lines in vitro by using a monolayer cell-survival and proliferation assay. Compound 7 was the most potent and exhibited a mean IC50 value of approximately 9.4 µM. Aniline 1 was synthesized by two routes in one-pot reactions starting from tert-butylamidoxime and 4-aminobenzoic acid or 4-nitrobenzonitrile. The structures of compounds 1, 2, 4, 5 and 6 were confirmed by X-ray crystallography.

In vitro Characterization of Microspheres Containing Chemically Cross- Linked Gummy Exudates of Cochlospermum religiosum

2019 ◽  
Vol 9 (3) ◽  
pp. 217-228
Author(s):  
Vipin Kumar Sharma ◽  
Bhaskar Mazumder ◽  
Vinod Nautiyal ◽  
Prince Prashant Sharma ◽  
Yusra Ahmed
Keyword(s):  
Diffusion Mechanism ◽  
Drug Carriers ◽  
X Ray Diffraction ◽  
Ether Linkage ◽  
X Ray ◽  
In Vitro Characterization ◽  
Pharmaceutical Industries ◽  
Novel Drug

Background: The polymeric hydrocolloids of natural origin such as gums and mucilages have their own significance in food and pharmaceutical industries due to safety, cost, biodegradability, biocompatibility, etc. Objective: This study includes the assessment of feasibility of gummy exudates of Cochlospermum religiosum for development of microspheres through emulsification technique. Methods: The effects of exudates concentration, glutaraldehyde amount and process temperature were analyzed on particle-size and swelling dynamics of developed microspheres. The formulations were also characterized by thermal decomposition and powder X-ray diffraction technique to assess the effect of crosslinking. Results: The photomicrographs of preparations revealed the formation of microspheres with smooth, spherical and free-flowing nature. The swelling dynamics followed Fick’s diffusion mechanism for swelling media. Fourier transform infrared spectroscopy showed the formation of ether-linkage after crosslinking of exudates by glutaraldehyde. The thermogravimetric curves disclosed the formation of strong bonds during crosslinking. Conclusion: The ease of gummy exudates of Cochlospermum religiosum for microspheres formation ascribed the potential of these formulations to incorporate therapeutic agent(s) to be applied as novel drug-carriers.

IN VITRO OSTEO-INDUCTIVE CHARACTERIZATION OF NANO-GRADE PEARL POWDERS

2011 ◽  
Vol 23 (02) ◽  
pp. 135-140
Author(s):  
Mei-Ju Hou ◽  
Chi-Jen Shih
Keyword(s):  
Inductively Coupled Plasma ◽  
Body Fluid ◽  
X Ray Diffraction ◽  
X Ray ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Hydroxyl Apatite ◽  
Inductive Behavior

The main objective of this study is to characterize the in vitro osteo inductive behavior of pearl nano crystallites. The results obtained from X-ray diffraction, Fourier transform infrared (FTIR) spectra, and inductively coupled plasma mass (ICP-MS) analysis demonstrate that the pearls can induce the formation of a hydroxyl apatite (HA) layer on their surface in simulated body fluid (SBF), even after only short soaking periods. Further, MC3T3-E1 cells can easily attach and spread on the pearl powders after 1 h of cultivation.

Spectroscopic and X-ray structural characterization of new organotin carboxylates and their in vitro antifungal activities

Polyhedron ◽  
2016 ◽  
Vol 117 ◽  
pp. 35-47 ◽  
Author(s):  
C.S. Rocha ◽  
B.P. de Morais ◽  
B.L. Rodrigues ◽  
C.L. Donnici ◽  
G.M. de Lima ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Antifungal Activities ◽  
X Ray

scholarly journals Radiological, geochemical, and mineralogical characterization of natural stones used in turkey

2017 ◽  
Vol 32 (3) ◽  
pp. 267-274
Author(s):  
Nil Yapici ◽  
Ferhat Gezer ◽  
Nusret Nurlu ◽  
Seref Turhan ◽  
Yuksel Ufuktepe
Keyword(s):  
Dose Rate ◽  
Germanium Detector ◽  
Spectroscopic Technique ◽  
Natural Stone ◽  
X Ray Diffraction ◽  
Mineralogical Characterization ◽  
Thin Sections ◽  
X Ray ◽  
Natural Stones

In the study, radiological, geochemical, and mineralogical characterization of natural stone samples used for covering or ornamental purposes collected from different quarries in Turkey was done using gamma spectrometric technique with high-purity germanium detector, X-ray fluorescence spectroscopic technique, X-ray diffraction technique and thin sections. The mean activity concentrations of 226Ra, 232Th, and 40K were measured in natural stone samples as 28.9, 30.8, and 355.0 Bqkg-1, respectively. The assessment of radiological hazards from utilization of stone samples as covering or ornamental material in building sector was made by estimating activity concentration index, absorbed gamma dose rate and annual effective dose rate. The examined natural stone samples were composed of calcite, dolomite, quartz, orthoclase, albite, biotite, hornblende, oligoclase, olivine and talc.

scholarly journals Preparation and Characterization of Paclitaxel Loaded SF/PLLA-PEG-PLLA Nanoparticles via Solution-Enhanced Dispersion by Supercritical CO2

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Zheng Zhao ◽  
Yi Li ◽  
Yu Zhang
Keyword(s):  
Supercritical Co2 ◽  
Crystalline State ◽  
Tumor Therapy ◽  
Ftir Analysis ◽  
Spectroscopy Analysis ◽  
X Ray ◽  
Release Property ◽  
Ph Dependent

Paclitaxel loaded silk fibroin/PLLA-PEG-PLLA (PTX-SF/PLLA-PEG-PLLA) nanoparticles with a mean particle size of about 651 nm were fabricated successfully by the SEDS process. Fourier transform infrared (FTIR) spectroscopy analysis indicated that the PTX was encapsulated by SF/PLLA-PEG-PLLA nanoparticles. X-ray powder diffraction (XRPD) analysis supported the results of FTIR analysis and also suggested that the crystalline state of PTX was decreased obviously. Furthermore, the UV-Vis/HPLC analysis showed that drug load (DL) and encapsulation efficiency (EE) were 18.1% and 90.2%, respectively. Thein vitrodrug release experiment suggested that the PTX-SF/PLLA-PEG-PLLA nanoparticles exhibited a sustained release and only 16.1% and 24.5% of paclitaxel were released at pH 7.4 and 6.0, respectively, in one week. The PTX-SF/PLLA-PEG-PLLA nanoparticles drug delivery system with pH-dependent release property has potential application in the field of tumor therapy.

Preparation and Characterization of Akermanite/Merwinite Scaffolds for Bone Tissue Repair

2020 ◽  
Vol 44 ◽  
pp. 73-81
Author(s):  
Mojtaba Ansari ◽  
Farzad Malmir ◽  
Amir Salati
Keyword(s):  
Bone Tissue ◽  
Bone Marrow Stromal Cells ◽  
Sol Gel ◽  
Magnesium Silicate ◽  
X Ray Diffraction ◽  
X Ray ◽  
Calcium Magnesium ◽  
Potential Use

The ceramics in the system CaO–MgO–SiO2 has recently attracted a great deal of attention because they display a good in vitro bioactivity and have potential use as bone implants. Biphasic calcium-magnesium-silicate ceramics were prepared by a sol-gel method. The dried gel with chemical composition 3CaO.MgO.2SiO2 was thermally treated at 1200 °C for 2 hrs. The structural behavior of the synthesized ceramics was examined by means of X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). Merwinite crystalline phase and akermanite phase were recognized. Then, porous akermanite/merwinite scaffolds were prepared to utilize polymer sponge method and evaluated by employing SEM. Furthermore, bone marrow stromal cells (BMSC) adhesion and proliferation on the scaffolds were evaluated by MTT assay test. Differentiation of the cells was assessed by measuring alkaline phosphatase (ALP) activity. The results demonstrated that BMSC adhered and spread well on akermanite scaffolds and proliferated with the increase in the culture time, and the differentiation rate of osteoblasts on scaffolds was comparable to that on blank culture plate control. Thus, the obtained results presented that the akermanite/merwinite scaffolds deserve attention for bone tissue engineering applications.

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