A 3D printed modular phantom for quality assurance of image‐guided small animal irradiators: Design, imaging experiments, and Monte Carlo simulations

2019 ◽  
Vol 46 (5) ◽  
pp. 2015-2024 ◽  
Author(s):  
Dylan Yamabe Breitkreutz ◽  
Spencer Bialek ◽  
Boris Vojnovic ◽  
Anthony Kavanagh ◽  
Christopher D. Johnstone ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Quality Assurance ◽  
Monte Carlo Simulations ◽  
Small Animal ◽  
Image Guided ◽  
3D Printed

scholarly journals A Monte Carlo Determination of Dose and Range Uncertainties for Preclinical Studies with a Proton Beam

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1889
Author(s):  
Arthur Bongrand ◽  
Charbel Koumeir ◽  
Daphnée Villoing ◽  
Arnaud Guertin ◽  
Ferid Haddad ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Monte Carlo Simulations ◽  
Proton Beam ◽  
Dose Response ◽  
Small Animal ◽  
Absorbed Dose ◽  
Normal Tissue Damage ◽  
Dose Homogeneity ◽  
And Control ◽  
The Impact

Proton therapy (PRT) is an irradiation technique that aims at limiting normal tissue damage while maintaining the tumor response. To study its specificities, the ARRONAX cyclotron is currently developing a preclinical structure compatible with biological experiments. A prerequisite is to identify and control uncertainties on the ARRONAX beamline, which can lead to significant biases in the observed biological results and dose–response relationships, as for any facility. This paper summarizes and quantifies the impact of uncertainty on proton range, absorbed dose, and dose homogeneity in a preclinical context of cell or small animal irradiation on the Bragg curve, using Monte Carlo simulations. All possible sources of uncertainty were investigated and discussed independently. Those with a significant impact were identified, and protocols were established to reduce their consequences. Overall, the uncertainties evaluated were similar to those from clinical practice and are considered compatible with the performance of radiobiological experiments, as well as the study of dose–response relationships on this proton beam. Another conclusion of this study is that Monte Carlo simulations can be used to help build preclinical lines in other setups.

scholarly journals Platform for automatic patient quality assurance via Monte Carlo simulations in proton therapy

2020 ◽  
Vol 70 ◽  
pp. 49-57 ◽  
Author(s):  
G. Guterres Marmitt ◽  
A. Pin ◽  
K. Ng Wei Siang ◽  
G. Janssens ◽  
K. Souris ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Quality Assurance ◽  
Monte Carlo Simulations ◽  
Proton Therapy

WE-E-108-10: Validating a 192Ir-Based Small Animal Irradiation Apparatus Using a 3D-Printed Applicator: Comparison Between TG-43, Monte Carlo and Films Dosimetry

2013 ◽  
Vol 40 (6Part29) ◽  
pp. 490-490 ◽  
Author(s):  
K Nie ◽  
C Collins Fekete ◽  
D Pinnaduwage ◽  
JAM Cunha ◽  
K Mellis ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Small Animal ◽  
Irradiation Apparatus ◽  
3D Printed

SU-E-T-274: Monte Carlo Simulations of Output Factors for a Small Animal Irradiator

2012 ◽  
Vol 39 (6Part14) ◽  
pp. 3766-3766
Author(s):  
R Pidikiti ◽  
S Stojadinovic ◽  
K Song ◽  
M Speiser ◽  
T Solberg
Keyword(s):  
Monte Carlo ◽  
Monte Carlo Simulations ◽  
Small Animal ◽  
Output Factors

Characterization of a New MR Compatible Small Animal PET Scanner Using Monte-Carlo Simulations

2013 ◽  
Vol 60 (3) ◽  
pp. 1637-1644 ◽  
Author(s):  
G. Stortz ◽  
M. D. Walker ◽  
C. J. Thompson ◽  
A. L. Goertzen ◽  
F. Retiere ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Monte Carlo Simulations ◽  
Small Animal ◽  
Small Animal Pet ◽  
Animal Pet
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