scholarly journals Diet Enriched with Olive Oil Attenuates Placental Dysfunction in Rats with Gestational Diabetes Induced by Intrauterine Programming

2018 ◽  
Vol 62 (19) ◽  
pp. 1800263 ◽  
Author(s):  
Evangelina Capobianco ◽  
Dalmiro Gomez Ribot ◽  
Daiana Fornes ◽  
Theresa L. Powell ◽  
Cecilia Levieux ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Olive Oil ◽  
Placental Dysfunction ◽  
Intrauterine Programming

Placental dysfunction and stillbirth in gestational diabetes mellitus

2009 ◽  
Vol 9 (1) ◽  
pp. 38-40 ◽  
Author(s):  
Ian W Campbell ◽  
Catriona Duncan ◽  
Rennie Urquhart ◽  
Margaret Evans
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Placental Dysfunction

Placental alterations in a new experimental model of gestational diabetes generated by intrauterine programming in the offspring of mild diabetic rats

Placenta ◽  
2014 ◽  
Vol 35 (9) ◽  
pp. A27
Author(s):  
Evangelina Capobianco ◽  
Daiana Fornes ◽  
Magalí Pelesson ◽  
Verónica White ◽  
Alicia Jawerbaum
Keyword(s):  
Gestational Diabetes ◽  
Experimental Model ◽  
Diabetic Rats ◽  
Intrauterine Programming

Intrauterine programming of lipid metabolic alterations in the heart of the offspring of diabetic rats is prevented by maternal diets enriched in olive oil

2015 ◽  
Vol 59 (10) ◽  
pp. 1997-2007 ◽  
Author(s):  
Evangelina Capobianco ◽  
Magalí Pelesson ◽  
Valeria Careaga ◽  
Daiana Fornes ◽  
Ivana Canosa ◽  
...  
Keyword(s):  
Olive Oil ◽  
Diabetic Rats ◽  
Metabolic Alterations ◽  
Intrauterine Programming

Metabolic abnormalities in the fetal liver of rats with gestational diabetes induced by intrauterine programming

Placenta ◽  
2015 ◽  
Vol 36 (4) ◽  
pp. 492
Author(s):  
Daiana Fornes ◽  
Romina Higa ◽  
Ivana Linenberg ◽  
Evangelina Capobianco ◽  
Alicia Jawerbaum
Keyword(s):  
Gestational Diabetes ◽  
Fetal Liver ◽  
Metabolic Abnormalities ◽  
Intrauterine Programming

Does a MediDiet with additional extra virgin olive oil (EVOO) and pistachios reduce the incidence of gestational diabetes?

2021 ◽  
Author(s):  
Li’na Zhao ◽  
Pinghua Zhang ◽  
Qianqian Zheng ◽  
Anupam Deka ◽  
Rupshikha Choudhury ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Olive Oil ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil

scholarly journals Addition of olive oil to diet of rats with mild pre-gestational diabetes impacts offspring β-cell development

2020 ◽  
Vol 246 (2) ◽  
pp. 175-187
Author(s):  
Bushra Taqui ◽  
Farzad Asadi ◽  
Evangelina Capobianco ◽  
Daniel Barry Hardy ◽  
Alicia Jawerbaum ◽  
...  
Keyword(s):  
Oleic Acid ◽  
Gestational Diabetes ◽  
Olive Oil ◽  
Metabolic Diseases ◽  
Cell Mass ◽  
Male Offspring ◽  
Chow Diet ◽  
Peroxisome Proliferator ◽  
Β Cells ◽  
Β Cell

Maternal diabetes impairs fetal development and increases the risk of metabolic diseases in the offspring. Previously, we demonstrated that maternal dietary supplementation with 6% of olive oil prevents diabetes-induced embryo and fetal defects, in part, through the activation of peroxisome proliferator-activated receptors (PPARs). In this study, we examined the effects of this diet on neonatal and adult pancreatic development in male and female offspring of mothers affected with pre-gestational diabetes. A mild diabetic model was developed by injecting neonatal rats with streptozotocin (90 mg/kg). During pregnancy, these dams were fed a chow diet supplemented or not with 6% olive oil. Offspring pancreata was examined at day 2 and 5 months of age by immunohistochemistry followed by morphometric analysis to determine number of islets, α and β cell clusters and β-cell mass. At 5 months, male offspring of diabetic mothers had reduced β-cell mass that was prevented by maternal supplementation with olive oil. PPARα and PPARγ were localized mainly in α cells and PPARβ/δ in both α and β cells. Although Pparβ/δ and Pparγ RNA expression showed reduction in 5-month-old male offspring of diabetic rats, Pparβ/δ expression returned to control levels after olive-oil supplementation. Interestingly, in vitro exposure to oleic acid (major component of olive oil) and natural PPAR agonists such as LTB4, CPC and 15dPGJ2 also significantly increased expression of all Ppars in αTC1–6 cells. However, only oleic acid and 15dPGJ2 increased insulin and Pdx-1 expression in INS-1E cells suggesting a protective role in β-cells. Olive oil may be considered a dietary supplement to improve islet function in offspring of affected mothers with pre-gestational diabetes.

A novel rat model of gestational diabetes induced by intrauterine programming is associated with alterations in placental signaling and fetal overgrowth

2016 ◽  
Vol 422 ◽  
pp. 221-232 ◽  
Author(s):  
Evangelina Capobianco ◽  
Daiana Fornes ◽  
Ivana Linenberg ◽  
Theresa L. Powell ◽  
Thomas Jansson ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Rat Model ◽  
Intrauterine Programming

Olive Oil Supplementation Reduces Proinflammatory Markers in the Placenta in a GDM Rat Model Induced by Intrauterine Programming

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1398-P
Author(s):  
DALMIRO L. GOMEZ RIBOT ◽  
EVANGELINA CAPOBIANCO ◽  
CECILIA P. LEVIEUX ◽  
DAIANA FORNES ◽  
ALICIA JAWERBAUM
Keyword(s):  
Olive Oil ◽  
Rat Model ◽  
Intrauterine Programming
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