Intrauterine programming of lipid metabolic alterations in the heart of the offspring of diabetic rats is prevented by maternal diets enriched in olive oil

2015 ◽  
Vol 59 (10) ◽  
pp. 1997-2007 ◽  
Author(s):  
Evangelina Capobianco ◽  
Magalí Pelesson ◽  
Valeria Careaga ◽  
Daiana Fornes ◽  
Ivana Canosa ◽  
...  
Keyword(s):  
Olive Oil ◽  
Diabetic Rats ◽  
Metabolic Alterations ◽  
Intrauterine Programming

scholarly journals Diet Enriched with Olive Oil Attenuates Placental Dysfunction in Rats with Gestational Diabetes Induced by Intrauterine Programming

2018 ◽  
Vol 62 (19) ◽  
pp. 1800263 ◽  
Author(s):  
Evangelina Capobianco ◽  
Dalmiro Gomez Ribot ◽  
Daiana Fornes ◽  
Theresa L. Powell ◽  
Cecilia Levieux ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Olive Oil ◽  
Placental Dysfunction ◽  
Intrauterine Programming

Placental alterations in a new experimental model of gestational diabetes generated by intrauterine programming in the offspring of mild diabetic rats

Placenta ◽  
2014 ◽  
Vol 35 (9) ◽  
pp. A27
Author(s):  
Evangelina Capobianco ◽  
Daiana Fornes ◽  
Magalí Pelesson ◽  
Verónica White ◽  
Alicia Jawerbaum
Keyword(s):  
Gestational Diabetes ◽  
Experimental Model ◽  
Diabetic Rats ◽  
Intrauterine Programming

Olive oil supplementation prevents extracellular matrix deposition and reduces prooxidant markers and apoptosis in the offspring´s heart of diabetic rats

2020 ◽  
Vol 95 ◽  
pp. 137-147
Author(s):  
Sabrina L. Roberti ◽  
Romina Higa ◽  
Hugo Sato ◽  
Dalmiro Gomez Ribot ◽  
Evangelina Capobianco ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Olive Oil ◽  
Diabetic Rats ◽  
Matrix Deposition ◽  
Extracellular Matrix Deposition

scholarly journals Peroxisome proliferator-activated receptor ligands regulate lipid content, metabolism, and composition in fetal lungs of diabetic rats

2014 ◽  
Vol 220 (3) ◽  
pp. 345-359 ◽  
Author(s):  
M Kurtz ◽  
E Capobianco ◽  
V Careaga ◽  
N Martinez ◽  
M B Mazzucco ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Olive Oil ◽  
Lung Development ◽  
Maternal Diabetes ◽  
Diabetic Rats ◽  
Lipid Homeostasis ◽  
Safflower Oil ◽  
Peroxisome Proliferator ◽  
Fetal Lungs ◽  
Ppar Ligands

Maternal diabetes impairs fetal lung development. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors relevant in lipid homeostasis and lung development. This study aims to evaluate the effect ofin vivoactivation of PPARs on lipid homeostasis in fetal lungs of diabetic rats. To this end, we studied lipid concentrations, expression of lipid metabolizing enzymes and fatty acid composition in fetal lungs of control and diabetic rats i) after injections of the fetuses with Leukotriene B4(LTB4, PPARα ligand) or 15deoxyΔ12,14prostaglandin J2(15dPGJ2, PPARγ ligand) and ii) fed during pregnancy with 6% olive oil- or 6% safflower oil-supplemented diets, enriched with PPAR ligands were studied. Maternal diabetes increased triglyceride concentrations and decreased expression of lipid-oxidizing enzymes in fetal lungs of diabetic rats, an expression further decreased by LTB4and partially restored by 15dPGJ2in lungs of male fetuses in the diabetic group. In lungs of female fetuses in the diabetic group, maternal diets enriched with olive oil increased triglyceride concentrations and fatty acid synthase expression, while those enriched with safflower oil increased triglyceride concentrations and fatty acid transporter expression. Both olive oil- and safflower oil-supplemented diets decreased cholesterol and cholesteryl ester concentrations and increased the expression of the reverse cholesterol transporter ATP-binding cassette A1 in fetal lungs of female fetuses of diabetic rats. In fetal lungs of control and diabetic rats, the proportion of polyunsaturated fatty acids increased with the maternal diets enriched with olive and safflower oils. Our results revealed important changes in lipid metabolism in fetal lungs of diabetic rats, and in the ability of PPAR ligands to modulate the composition of lipid species relevant in the lung during the perinatal period.

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