Plasma B vitamins and LINE-1 DNA methylation in leukocytes of patients with a history of colorectal adenomas

2012 ◽  
Vol 57 (4) ◽  
pp. 698-708 ◽  
Author(s):  
Audrey Y. Jung ◽  
Akke Botma ◽  
Carolien Lute ◽  
Henk J. Blom ◽  
Per M. Ueland ◽  
...  
Keyword(s):  
Dna Methylation ◽  
B Vitamins ◽  
Colorectal Adenomas ◽  
History Of

scholarly journals DNA Methylation in T-Cell Acute Lymphoblastic Leukemia: In Search for Clinical and Biological Meaning

2021 ◽  
Vol 22 (3) ◽  
pp. 1388
Author(s):  
Natalia Maćkowska ◽  
Monika Drobna-Śledzińska ◽  
Michał Witt ◽  
Małgorzata Dawidowska
Keyword(s):  
Dna Methylation ◽  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Epigenetic Modification ◽  
Lymphoblastic Leukemia ◽  
Leukemic Cells ◽  
Global Methylation ◽  
Current State ◽  
History Of ◽  
Cell Acute Lymphoblastic Leukemia

Distinct DNA methylation signatures, related to different prognosis, have been observed across many cancers, including T-cell acute lymphoblastic leukemia (T-ALL), an aggressive hematological neoplasm. By global methylation analysis, two major phenotypes might be observed in T-ALL: hypermethylation related to better outcome and hypomethylation, which is a candidate marker of poor prognosis. Moreover, DNA methylation holds more than a clinical meaning. It reflects the replicative history of leukemic cells and most likely different mechanisms underlying leukemia development in these T-ALL subtypes. The elucidation of the mechanisms and aberrations specific to (epi-)genomic subtypes might pave the way towards predictive diagnostics and precision medicine in T-ALL. We present the current state of knowledge on the role of DNA methylation in T-ALL. We describe the involvement of DNA methylation in normal hematopoiesis and T-cell development, focusing on epigenetic aberrations contributing to this leukemia. We further review the research investigating distinct methylation phenotypes in T-ALL, related to different outcomes, pointing to the most recent research aimed to unravel the biological mechanisms behind differential methylation. We highlight how technological advancements facilitated broadening the perspective of the investigation into DNA methylation and how this has changed our understanding of the roles of this epigenetic modification in T-ALL.

scholarly journals History of parvovirus B19 infection is associated with a DNA methylation signature in childhood acute lymphoblastic leukemia

Epigenetics ◽  
2011 ◽  
Vol 6 (12) ◽  
pp. 1436-1443 ◽  
Author(s):  
Gisele M. Vasconcelos ◽  
Brock C. Christensen ◽  
E. Andrés Houseman ◽  
Jianqiao Xiao ◽  
Carmen J. Marsit ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Acute Lymphoblastic Leukemia ◽  
Parvovirus B19 ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
History Of ◽  
Parvovirus B19 Infection

scholarly journals Genetic susceptibility in the development of colorectal adenomas according to family history of colorectal cancer

2018 ◽  
Vol 144 (3) ◽  
pp. 489-502 ◽  
Author(s):  
Carla J. Gargallo ◽  
Ángel Lanas ◽  
Patricia Carrera‐Lasfuentes ◽  
Ángel Ferrandez ◽  
Enrique Quintero ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Genetic Susceptibility ◽  
Colorectal Adenomas ◽  
History Of

scholarly journals Prediagnostic breast milk DNA methylation alterations in women who develop breast cancer

2020 ◽  
Vol 29 (4) ◽  
pp. 662-673 ◽  
Author(s):  
Lucas A Salas ◽  
Sara N Lundgren ◽  
Eva P Browne ◽  
Elizabeth C Punska ◽  
Douglas L Anderton ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Breast Milk ◽  
Cancer Diagnosis ◽  
Breast Biopsy ◽  
Disease Risk ◽  
Breast Cancer Diagnosis ◽  
Milk Samples ◽  
Cpg Sites ◽  
History Of

Abstract Prior candidate gene studies have shown tumor suppressor DNA methylation in breast milk related with history of breast biopsy, an established risk factor for breast cancer. To further establish the utility of breast milk as a tissue-specific biospecimen for investigations of breast carcinogenesis, we measured genome-wide DNA methylation in breast milk from women with and without a diagnosis of breast cancer in two independent cohorts. DNA methylation was assessed using Illumina HumanMethylation450k in 87 breast milk samples. Through an epigenome-wide association study we explored CpG sites associated with a breast cancer diagnosis in the prospectively collected milk samples from the breast that would develop cancer compared with women without a diagnosis of breast cancer using linear mixed effects models adjusted for history of breast biopsy, age, RefFreeCellMix cell estimates, time of delivery, array chip and subject as random effect. We identified 58 differentially methylated CpG sites associated with a subsequent breast cancer diagnosis (q-value <0.05). Nearly all CpG sites associated with a breast cancer diagnosis were hypomethylated in cases compared with controls and were enriched for CpG islands. In addition, inferred repeat element methylation was lower in breast milk DNA from cases compared to controls, and cases exhibited increased estimated epigenetic mitotic tick rate as well as DNA methylation age compared with controls. Breast milk has utility as a biospecimen for prospective assessment of disease risk, for understanding the underlying molecular basis of breast cancer risk factors and improving primary and secondary prevention of breast cancer.

scholarly journals Global DNA methylation levels in girls with and without a family history of breast cancer

Epigenetics ◽  
2011 ◽  
Vol 6 (1) ◽  
pp. 29-33 ◽  
Author(s):  
Hui-Chen Wu ◽  
Esther M. John ◽  
Jennifer S. Ferris ◽  
Theresa H. Keegan ◽  
Wendy K. Chung ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Family History ◽  
Global Dna Methylation ◽  
History Of

Risk factors of colorectal adenoma recurrence among individuals under 50 years of age compared to those 50 years of age or older.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 1554-1554
Author(s):  
Christine Louise Sardo Molmenti ◽  
Jingyan Yang ◽  
Cynthia A Thomson ◽  
Elizabeth A Hibler ◽  
Gloria Ho ◽  
...  
Keyword(s):  
Risk Factors ◽  
Colorectal Adenoma ◽  
Colorectal Adenomas ◽  
Age Group ◽  
Current Smoking ◽  
Adenoma Recurrence ◽  
Younger Age ◽  
History Of ◽  
Colorectal Adenoma Recurrence

1554 Background: Colorectal cancer incidence and mortality are increasing among individuals < 50 years of age. Data are limited regarding the epidemiology of colorectal adenomas in this younger age group. This study investigated and compared risk factors associated with recurrence of adenomas in individuals under and over 50 years of age. Methods: Pooled analyses from the Wheat Bran Fiber and Ursodeoxycholic Acid phase III, randomized, controlled clinical trials included 1,623 participants, aged 40-80 years. Each completed baseline questionnaires related to family history and lifestyle habits, had one or more colorectal adenomas removed at baseline, and had a follow-up colonoscopy during the trial (mean follow up 36 months). Univariate and multivariate logistic regression modeling estimated the association between age and colorectal adenoma recurrence, and evaluate multiple risk factors, while controlling for confounding factors. Results: A statistically significant increased trend was found for colorectal adenoma recurrence with increasing age ( Ptrend= < 0.001). Multivariate logistic regression revealed that risk factors significantly associated with adenoma recurrence in the ≥50 age group (n = 1,523) included history of previous polyps, characteristics of adenomas removed at baseline (multiple adenomas and villous feature), current smoking, and an increased waist circumference. Although risk profile in the < 50 age group (n = 95) shared similarities with that in the ≥50 age group (e.g., current smoking), there were a few notable differences: history of previous polyps was a more prominent predictor for recurrence for the < 50 (OR< 50 = 4.76 and OR≥50 = 1.33, Pinteraction = 0.042), whereas baseline characteristics of adenomas were more important for the ≥50 (multiple adenomas: OR< 50 = 0.40 and OR≥50 = 2.28, Pinteraction = 0.043). Conclusions: Predisposition to colorectal adenoma is a more important risk factor for recurrence in the < 50 as compared to the ≥50. Future studies need to identify susceptibility factors contributing to the increasing incidence of colorectal cancer in this younger age group.

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