scholarly journals Genetic susceptibility in the development of colorectal adenomas according to family history of colorectal cancer

2018 ◽  
Vol 144 (3) ◽  
pp. 489-502 ◽  
Author(s):  
Carla J. Gargallo ◽  
Ángel Lanas ◽  
Patricia Carrera‐Lasfuentes ◽  
Ángel Ferrandez ◽  
Enrique Quintero ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Genetic Susceptibility ◽  
Colorectal Adenomas ◽  
History Of

scholarly journals Risk of colorectal adenomas in patients with a family history of colorectal cancer: some implications for screening programmes.

Gut ◽  
1996 ◽  
Vol 39 (1) ◽  
pp. 105-108 ◽  
Author(s):  
J F Aitken ◽  
C J Bain ◽  
M Ward ◽  
V Siskind ◽  
R MacLennan
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Colorectal Adenomas ◽  
History Of

Colorectal Cancer in the Royal Navy – an opportunity to intervene?

1995 ◽  
Vol 81 (1) ◽  
pp. 16-26
Author(s):  
N P J Cripps ◽  
L B Cannon
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Early Detection ◽  
Disease Incidence ◽  
Occult Blood ◽  
Population Based ◽  
Colorectal Adenomas ◽  
Royal Navy ◽  
History Of ◽  
The Impact

AbstractColorectal cancer is uncommon in Royal Naval personnel; an average of two cases are diagnosed annually, often with disease advanced at presentation. During the next five years, IO serving individuals arelikely to present with colorectal cancer and many, ifnot all of these, already harbour premalignantadenomas or asymptomatic colonic malignancy.Currently over 2,000 servicemen are estimated tocarry undiagnosed colorectal adenomas..Requests for hospital appointments for those reporting a family history of colorectal cancer and who request screening are increasing in frequency. An understanding of the personal implications of a familyhistory of colorectal cancer and a basis for the management of these individuals will be provided.This paper considers ways in which the impact of colorectal cancer on the Royal Navy and its pensioners could be altered. Evidence derived from population based and family hi story based colorectal cancer screening studies are organised into a protocol by which the Royal Navy might be examined. The effect of a family history of colorectal cancer on disease incidence and the percentage of positives resulting from faecal occult blood testing are applied to the ageprofile of the Royal Navy. These show that amaximum of 56 flexible sigmoidoscopies and 90colonoscopies would be needed in the first year of aprogramme to attempt the early detection of neoplasia.This paper is aimed at gaining feedback from primary and secondary care practitioners so that the possibility of introducing a programme for the early detection of colorectal cancer in the Royal Navy canbe considered.

scholarly journals Variables associated with the risk of colorectal adenomas in asymptomatic patients with a family history of colorectal cancer.

Gut ◽  
1995 ◽  
Vol 36 (3) ◽  
pp. 385-390 ◽  
Author(s):  
P Gaglia ◽  
W S Atkin ◽  
S Whitelaw ◽  
I C Talbot ◽  
C B Williams ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Colorectal Adenomas ◽  
Asymptomatic Patients ◽  
History Of

scholarly journals Flow cytometric DNA ploidy in colorectal adenomas and family history of colorectal cancer

Cancer ◽  
1988 ◽  
Vol 61 (1) ◽  
pp. 114-120 ◽  
Author(s):  
Stefania Sciallero ◽  
Hugo Aste ◽  
Silvia Bruno ◽  
Angela Di Vinci ◽  
Elio Geido ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Dna Ploidy ◽  
Colorectal Adenomas ◽  
Flow Cytometric ◽  
History Of

scholarly journals Clinical, Pathological and Molecular Characteristics of Chilean Patients with Early-, Intermediate- and Late-Onset Colorectal Cancer

Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 631
Author(s):  
Karin Alvarez ◽  
Alessandra Cassana ◽  
Marjorie De La Fuente ◽  
Tamara Canales ◽  
Mario Abedrapo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Age Of Onset ◽  
Late Onset ◽  
Molecular Characteristics ◽  
Family History Of Cancer ◽  
Molecular Features ◽  
Age Of Diagnosis ◽  
History Of ◽  
History Of Cancer

Colorectal cancer (CRC) is the second most frequent neoplasm in Chile and its mortality rate is rising in all ages. However, studies characterizing CRC according to the age of onset are still lacking. This study aimed to identify clinical, pathological, and molecular features of CRC in Chilean patients according to the age of diagnosis: early- (≤50 years; EOCRC), intermediate- (51–69 years; IOCRC), and late-onset (≥70 years; LOCRC). The study included 426 CRC patients from Clinica Las Condes, between 2007 and 2019. A chi-square test was applied to explore associations between age of onset and clinicopathological characteristics. Body Mass Index (BMI) differences according to age of diagnosis was evaluated through t-test. Overall (OS) and cancer-specific survival (CSS) were estimated by the Kaplan–Meier method. We found significant differences between the age of onset, and gender, BMI, family history of cancer, TNM Classification of Malignant Tumors stage, OS, and CSS. EOCRC category was characterized by a family history of cancer, left-sided tumors with a more advanced stage of the disease but better survival at 10 years, and lower microsatellite instability (MSI), with predominant germline mutations. IOCRC has shown clinical similarities with the EOCRC and molecular similarities to the LOCRC, which agrees with other reports.

scholarly journals The Association of Tumor Microsatellite Instability Phenotype with Family History of Colorectal Cancer

2009 ◽  
Vol 18 (3) ◽  
pp. 967-975 ◽  
Author(s):  
Bharati Bapat ◽  
Noralane M. Lindor ◽  
John Baron ◽  
Kim Siegmund ◽  
Lin Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Microsatellite Instability ◽  
History Of ◽  
Instability Phenotype

939 Association Between Family History of Colorectal Cancer and Incident Colorectal Cancer in the PLCO Trial

2014 ◽  
Vol 146 (5) ◽  
pp. S-162-S-163
Author(s):  
Anthony Razzak ◽  
Kelly Yu ◽  
Paul Pinsky ◽  
Tom Riley ◽  
Robert E. Schoen
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
History Of
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