Studies on the carbohydrate metabolism of sheep. 5. The effect of hyperglycaemia and of insulin on the rate of extrahepatic glucose assimilation

1952 ◽  
Vol 3 (2) ◽  
pp. 160 ◽  
Author(s):  
RL Reid
Keyword(s):  
Blood Glucose ◽  
General Circulation ◽  
Glucose Absorption ◽  
Partial Explanation ◽  
Intravenous Glucose ◽  
Glucose Injection ◽  
Direct Administration ◽  
Extrahepatic Tissues ◽  
Carbohydrate Digestion ◽  
Glucose Assimilation

Significant increases in the arterio-venous glucose difference have not been observed constantly in sheep either during the hyperglycaemia which follows intravenous glucose injection or during the period in which the blood glucose is falling after insulin administration. It is suggested that the low rate of extrahepatic glucose assimilation at hyperglycaemic levels provides a partial explanation of the relatively slow rate of clearance of injected glucose from the general circulation of ruminants. Blood-glucose curves, obtained after direct administration of glucose into the abomasum, are discussed in the light of these findings, and it is concluded that the rate of glucose absorption from the intestine of the sheep is low compared with the rate in non-ruminants. It is suggested further that hexokinase activity in the extrahepatic tissues of the sheep is relatively low, and that the findings described are conditioned principally by the nature of carbohydrate digestion and metabolism in the ruminant.

APPLICATION DE LA DOUBLE ÉPREUVE D'HYPERGLYCÉMIE INTRAVEINEUSE À L'ÉTUDE DU DIABÈTE

1960 ◽  
Vol XXXIII (II) ◽  
pp. 157-167
Author(s):  
T. Rodari ◽  
G. Specchia
Keyword(s):  
Glucose Tolerance ◽  
Pancreatic Islet ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Intravenous Glucose Tolerance Test ◽  
Intravenous Glucose ◽  
Intravenous Glucose Tolerance ◽  
Glucose Assimilation

ABSTRACT The double intravenous glucose tolerance test does not modify the assimilation coefficient in normal and thin diabetic subjects. On the contrary, in fat diabetic subjects the second coefficient of assimilation increases significantly, but not the first one. From these researches it is evident that the valuation of glucose assimilation by double venous hyperglycaemic test indicates the functional behaviour of the pancreas in different diabetic states. The interpretation of this behaviour of pancreatic islet response to the double venous hyperglycaemic test is discussed.

scholarly journals Mechanisms of Glucose Absorption in the Small Intestine in Health and Metabolic Diseases and Their Role in Appetite Regulation

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2474
Author(s):  
Lyudmila V. Gromova ◽  
Serguei O. Fetissov ◽  
Andrey A. Gruzdkov
Keyword(s):  
Small Intestine ◽  
Blood Glucose ◽  
Metabolic Diseases ◽  
Glucose Absorption ◽  
Cellular Mechanisms ◽  
Physiological Conditions ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
New Strategy ◽  
Intestinal Glucose Absorption

The worldwide prevalence of metabolic diseases such as obesity, metabolic syndrome and type 2 diabetes shows an upward trend in recent decades. A characteristic feature of these diseases is hyperglycemia which can be associated with hyperphagia. Absorption of glucose in the small intestine physiologically contributes to the regulation of blood glucose levels, and hence, appears as a putative target for treatment of hyperglycemia. In fact, recent progress in understanding the molecular and cellular mechanisms of glucose absorption in the gut and its reabsorption in the kidney helped to develop a new strategy of diabetes treatment. Changes in blood glucose levels are also involved in regulation of appetite, suggesting that glucose absorption may be relevant to hyperphagia in metabolic diseases. In this review we discuss the mechanisms of glucose absorption in the small intestine in physiological conditions and their alterations in metabolic diseases as well as their relevance to the regulation of appetite. The key role of SGLT1 transporter in intestinal glucose absorption in both physiological conditions and in diabetes was clearly established. We conclude that although inhibition of small intestinal glucose absorption represents a valuable target for the treatment of hyperglycemia, it is not always suitable for the treatment of hyperphagia. In fact, independent regulation of glucose absorption and appetite requires a more complex approach for the treatment of metabolic diseases.

Insulin resistance induced by long-term sleep deprivation in rhesus macaques can be attenuated by Bifidobacterium

2021 ◽  
Author(s):  
Ying Zhao ◽  
Yan Shu ◽  
Ning Zhao ◽  
Zili Zhou ◽  
Xiong Jia ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Circadian Rhythm ◽  
Blood Glucose ◽  
Glucose Metabolism ◽  
Sleep Deprivation ◽  
Rhesus Macaques ◽  
Intravenous Glucose ◽  
Increased Risk ◽  
The Impact

Long-term sleep deprivation (SD) is a bad lifestyle habit, especially among specific occupational practitioners, characterized by circadian rhythm misalignment and abnormal sleep/wake cycles. SD is closely associated with an increased risk of metabolic disturbance, particularly obesity and insulin resistance. The incretin hormone, glucagon-like peptide-1 (GLP-1), is a critical insulin release determinant secreted by the intestinal L-cell upon food intake. Besides, the gut microbiota participates in metabolic homeostasis and regulates GLP-1 release in a circadian rhythm manner. As a commonly recognized intestinal probiotic, Bifidobacterium has various clinical indications regarding its curative effect. However, few studies have investigated the effect of Bifidobacterium supplementation on sleep disorders. In the present study, we explored the impact of long-term SD on the endocrine metabolism of rhesus monkeys and determined the effect of Bifidobacterium supplementation on the SD-induced metabolic status. Lipids concentrations, body weight, fast blood glucose, and insulin levels increased after SD. Furthermore, after two months of long-term SD, the intravenous glucose tolerance test (iVGTT) showed that the glucose metabolism was impaired and the insulin sensitivity decreased. Moreover, one month of Bifidobacterium oral administration significantly reduced blood glucose and attenuated insulin resistance in rhesus macaques. Overall, our results suggested that Bifidobacterium might be used to alleviate SD-induced aberrant glucose metabolism and improve insulin resistance. Also, it might help in better understanding the mechanisms governing the beneficial effects of Bifidobacterium.

scholarly journals Potential of Syzygium polyanthum (Daun Salam) in Lowering Blood Glucose Level: A Review

2021 ◽  
Vol 29 (4) ◽  
Author(s):  
Nur Salsabeela Mohd Rahim ◽  
Ida Farah Ahmad ◽  
Terence Yew Chin Tan
Keyword(s):  
Blood Glucose ◽  
Scientific Evidence ◽  
Safety Evaluation ◽  
Underlying Mechanism ◽  
Glucose Absorption ◽  
Diabetic Patients ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Herbal Decoction ◽  
Intestinal Glucose Absorption

Syzygium polyanthum is a herb widely used in Malaysia and Indonesia in cuisines. Traditionally, the herbal decoction of S. polyanthum (daun salam) leaves is often used by diabetic patients in Indonesia. Therefore, our objective is to evaluate the scientific evidence available for S. polyanthum in lowering blood glucose levels (BGL). We systematically searched Pubmed, Google Scholar, Scopus, CENTRAL. LILAC and clinicaltrials.gov databases up to 23rd October 2020 using the keywords “Syzygium polyanthum” and “antidiabetic”. From the selected 413 articles, eight studies involving rodents were included. All results showed a significant effect in lowering BGL without any adverse effects. The possible underlying mechanism of action is attributed to inhibiting intestinal glucose absorption and enhancing glucose uptake by the muscles. Chemical families responsible for the effect were determined as flavonoids, alkaloids and terpenoids. Thus, S. polyanthum leaves showed potential antidiabetic properties, but further research is required to identify the active compounds followed by the safety evaluation of this compound.

Insulin Sensitivity Accounts for Glucose and Lactate Kinetics After Intravenous Glucose Injection

Diabetes ◽  
1995 ◽  
Vol 44 (8) ◽  
pp. 954-962 ◽  
Author(s):  
R. M. Watanabe ◽  
J. Lovejoy ◽  
G. M. Steil ◽  
M. DiGirolamo ◽  
R. N. Bergman
Keyword(s):  
Insulin Sensitivity ◽  
Intravenous Glucose ◽  
Lactate Kinetics ◽  
Glucose Injection

scholarly journals Differences in Alimentary Glucose Absorption and Intestinal Disposal of Blood Glucose After Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy

2016 ◽  
Vol 150 (2) ◽  
pp. 454-464.e9 ◽  
Author(s):  
Jean-Baptiste Cavin ◽  
Anne Couvelard ◽  
Rachida Lebtahi ◽  
Robert Ducroc ◽  
Konstantinos Arapis ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Sleeve Gastrectomy ◽  
Blood Glucose ◽  
Glucose Absorption

Comparison of two glucose-monitoring systems for use in horses

2022 ◽  
pp. 1-7
Author(s):  
Caitlin E. Malik ◽  
David M. Wong ◽  
Katarzyna A. Dembek ◽  
Katherine E. Wilson
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Concentration ◽  
Point Of Care ◽  
Glucose Monitoring ◽  
Glucose Absorption ◽  
Monitoring Systems ◽  
Oral Glucose ◽  
Clinically Normal ◽  
Freestyle Libre ◽  
Interstitial Glucose

Abstract OBJECTIVE To determine the accuracy of 2 interstitial glucose-monitoring systems (GMSs) for use in horses compared with a point-of-care (POC) glucometer and standard laboratory enzymatic chemistry method (CHEM). ANIMALS 8 clinically normal adult horses. PROCEDURES One of each GMS device (Dexcom G6 and Freestyle Libre 14-day) was placed on each horse, and blood glucose concentration was measured via POC and CHEM at 33 time points and compared with simultaneous GMS readings. An oral glucose absorption test (OGAT) was performed on day 2, and glucose concentrations were measured and compared. RESULTS Glucose concentrations were significantly correlated with one another between all devices on days 1 to 5. Acceptable agreement was observed between Dexcom G6 and Freestyle Libre 14-day when compared with CHEM on days 1, 3, 4, and 5 with a combined mean bias of 10.45 mg/dL and 1.53 mg/dL, respectively. During dextrose-induced hyperglycemia on day 2, mean bias values for Dexcom G6 (10.49 mg/dL) and FreeStyle Libre 14-day (0.34 mg/dL) showed good agreement with CHEM. CLINICAL RELEVANCE Serial blood glucose measurements are used to diagnose or monitor a variety of conditions in equine medicine; advances in near-continuous interstitial glucose monitoring allow for minimally invasive glucose assessment, thereby reducing stress and discomfort to patients. Data from this study support the use of the Dexcom G6 and Freestyle Libre 14-day interstitial glucose-monitoring systems to estimate blood glucose concentrations in horses.

Carbohydrate Tolerance Status in Patients with Myocardial Infarction

1990 ◽  
Vol 45 (1-2) ◽  
pp. 125-128
Author(s):  
M. Ataur Rahman ◽  
Hasna Begum ◽  
Abdus Samad ◽  
S. Shahjehan
Keyword(s):  
Myocardial Infarction ◽  
Glucose Tolerance ◽  
Half Life ◽  
Insulin Level ◽  
Intravenous Glucose Tolerance Test ◽  
Intravenous Glucose ◽  
Control Subjects ◽  
Intravenous Glucose Tolerance ◽  
Glucose Assimilation ◽  
Glucose Assimilation Coefficient

Abstract Hyperglycemia is an important independent risk factor in the development of coronary artery disease. Sixty one patients suffering from chronic and acute myocardial infarction out of which 12 patients were diabetic and 10 normal control subjects were investigated. The patients without diabetes and control subjects were subjected to oral and intravenous glucose tolerance tests. It was observed that the post load glucose level of most of the patients and fasting insulin level of patients without diabetes were higher as compared with control subjects. From the intravenous glucose tolerance test, half life of glucose and glucose assimilation coefficient were determined. Half life of glucose was increased significantly and glucose assimilation coefficient was decreased in the patients with myocardial infarction as compared with those of control subjects. The observations confirm that carbohydrate intolerance in myocardial infarction is not due to suppression of insulin secretion but due to peripheral utilization.

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