scholarly journals Cancer chemoprevention and chemotherapy: Dietary polyphenols and signalling pathways

2008 ◽  
Vol 52 (5) ◽  
pp. 507-526 ◽  
Author(s):  
Sonia Ramos
Keyword(s):  
Cancer Chemoprevention ◽  
Signalling Pathways ◽  
Dietary Polyphenols

Cancer Chemoprevention by Dietary Polyphenols, Flavonoids, Terpenoids, and Saponins

2019 ◽  
pp. 91-109 ◽  
Author(s):  
Rahul L. Gajbhiye ◽  
Sanjit K. Mahato ◽  
Anushree Achari ◽  
Parasuraman Jaisankar ◽  
V. Ravichandiran
Keyword(s):  
Cancer Chemoprevention ◽  
Dietary Polyphenols

scholarly journals Cancer chemoprevention by dietary polyphenols: Promising role for epigenetics

2010 ◽  
Vol 80 (12) ◽  
pp. 1771-1792 ◽  
Author(s):  
Alexander Link ◽  
Francesc Balaguer ◽  
Ajay Goel
Keyword(s):  
Cancer Chemoprevention ◽  
Dietary Polyphenols

scholarly journals Cancer Chemoprevention by Flavonoids, Dietary Polyphenols and Terpenoids

2020 ◽  
Vol 11 (1) ◽  
pp. 8502-8537 ◽  
Keyword(s):  
Gut Microbiota ◽  
Human Health ◽  
Qualitative Content Analysis ◽  
Cancer Chemoprevention ◽  
Research Literature ◽  
Microbial Interactions ◽  
Bibliographic Databases ◽  
World Population ◽  
Dietary Polyphenols ◽  
Cost Effective Treatment

The world population is aging, and cancer is always considered to be one of the major causes of death all over the globe. The advent of recent drug-targeted therapies undoubtedly is going to reduce the incidence of cancer over the coming years. However, the frequency of occurrence of such chronic diseases like cancer would continue to increase. Therefore, the search for a safer and cost-effective treatment is urgently needed. Phytochemicals found in plants, foods, vegetables, tea, etc. have emerged as proven therapeutic compounds modulating signaling pathways involved in cancer. We carried out a structured search of bibliographic databases for peer-reviewed research literature using the keywords: cancer chemoprevention, flavonoids, dietary polyphenols, terpenoids, bioactive, microbiota. Quality of the retrieved papers and characteristic outcomes of the articles included in the study was assessed by employing standard tools and deductive qualitative content analysis methodology. The development of personalized supplements comprising particular phytochemicals has been the key, especially dealing with chronic inflammatory disorders like cancer. Better understanding at the molecular level explains the influence of phytochemicals on human health, which has been extensively covered through this review. Moreover, the wide collection of dietary polyphenols that has significant properties in reference to human health has been highlighted. Furthermore, the etiology of end products of such phytochemicals, especially on the modulation of gut microbiota and the host-microbial interactions thereof, need to be properly understood. The present study summarizes the chemoprevention and treatment of cancer using the bioactive components, including flavonoids, dietary polyphenols, and terpenoids. Likewise, the effect of dietary polyphenols on the human gut microbiota has been realized more recently. However, more research is needed in this field, especially focused on the communications, interlinks between the gut microbiota and polyphenols with the precise mechanism of action.

Cancer Chemoprevention by Dietary Polyphenols

2014 ◽  
pp. 1199-1216
Author(s):  
Karen Heyninck ◽  
Guy Haegeman ◽  
Ajay Goel
Keyword(s):  
Cancer Chemoprevention ◽  
Dietary Polyphenols

scholarly journals Cancer Chemoprevention by Dietary Polyphenols

10.5772/54945 ◽  
2013 ◽  
Author(s):  
Magdy Sayed ◽  
Amani Abd ElHamid Mahmou
Keyword(s):  
Cancer Chemoprevention ◽  
Dietary Polyphenols

scholarly journals Immunomodulatory phytochemicals for chemoprevention

2021 ◽  
Vol 8 (2) ◽  
pp. 49-58
Author(s):  
Surendra Agrawal ◽  
Pravin O. Patil
Keyword(s):  
Mortality Rate ◽  
Molecular Targets ◽  
Signalling Pathways ◽  
Severe Toxicity ◽  
Dietary Polyphenols ◽  
Modern System ◽  
Cox 2 ◽  
Inflammatory Action ◽  
Remarkable Progress

Chemoprevention and chemotherapeutics with traditional and complimentary system has gained importance with increase in the relapse cases treated with modern system of medicine. The increased mortality rate due to severe toxicity is another concern. The role of phytochemicals from different class viz-dietary polyphenols and saponins in chemoprevention along with different mechanistic pathways has created remarkable progress as the toxicity issues are of lesser concern. Phytochemicals can prevent the carcinogenesis process via antioxidant or anti-inflammatory action by modulating the proteins involved in different pathways like NF-kB, Nrf-2, AP-1, MAPK, and COX-2. In this review, we have focused on the potential molecular targets and signalling pathways that provoke the tumorigenesis process and the various phytochemicals that are targeted towards these signalling pathways by chemoprevention.

scholarly journals Dietary Polyphenols in Cancer Chemoprevention: Implications in Pancreatic Cancer

Antioxidants ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 651
Author(s):  
Anita Thyagarajan ◽  
Andrew S. Forino ◽  
Raymond L. Konger ◽  
Ravi P. Sahu
Keyword(s):  
Oxidative Stress ◽  
Pancreatic Cancer ◽  
Drug Targets ◽  
Folk Medicine ◽  
Antioxidant Properties ◽  
Cancer Chemoprevention ◽  
Chemotherapeutic Agents ◽  
Dietary Polyphenols ◽  
Beneficial Effects ◽  
Stress Levels

Naturally occurring dietary agents present in a wide variety of plant products, are rich sources of phytochemicals possessing medicinal properties, and thus, have been used in folk medicine for ages to treat various ailments. The beneficial effects of such dietary components are frequently attributed to their anti-inflammatory and antioxidant properties, particularly in regards to their antineoplastic activities. As many tumor types exhibit greater oxidative stress levels that are implicated in favoring autonomous cell growth activation, most chemotherapeutic agents can also enhance tumoral oxidative stress levels in part via generating reactive oxygen species (ROS). While ROS-mediated imbalance of the cellular redox potential can provide novel drug targets, as a consequence, this ROS-mediated excessive damage to cellular functions, including oncogenic mutagenesis, has also been implicated in inducing chemoresistance. This remains one of the major challenges in the treatment and management of human malignancies. Antioxidant-enriched natural compounds offer one of the promising approaches in mitigating some of the underlying mechanisms involved in tumorigenesis and metastasis, and therefore, have been extensively explored in cancer chemoprevention. Among various groups of dietary phytochemicals, polyphenols have been extensively explored for their underlying chemopreventive mechanisms in other cancer models. Thus, the current review highlights the significance and mechanisms of some of the highly studied polyphenolic compounds, with greater emphasis on pancreatic cancer chemoprevention.

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