Clinical role of lipid transfer proteins in food allergy

2004 ◽  
Vol 48 (5) ◽  
pp. 356-362 ◽  
Author(s):  
Elide A. Pastorello ◽  
Anna M. Robino
Keyword(s):  
Food Allergy ◽  
Lipid Transfer ◽  
Lipid Transfer Proteins ◽  
Clinical Role

Role of plant lipid transfer proteins in plant cell physiology—A concise review

Peptides ◽  
2007 ◽  
Vol 28 (5) ◽  
pp. 1144-1153 ◽  
Author(s):  
André de Oliveira Carvalho ◽  
Valdirene Moreira Gomes
Keyword(s):  
Plant Cell ◽  
Cell Physiology ◽  
Lipid Transfer ◽  
Lipid Transfer Proteins ◽  
Plant Lipid ◽  
Concise Review

scholarly journals Role of the Sec22b–E-Syt complex in neurite growth and ramification

2020 ◽  
Vol 133 (18) ◽  
pp. jcs247148 ◽  
Author(s):  
Alessandra Gallo ◽  
Lydia Danglot ◽  
Francesca Giordano ◽  
Bailey Hewlett ◽  
Thomas Binz ◽  
...  
Keyword(s):  
Nervous System ◽  
Opposite Effect ◽  
Neurite Growth ◽  
Lipid Transfer ◽  
Wild Type ◽  
Lipid Transfer Proteins ◽  
Contact Sites ◽  
Developing Neurons ◽  
Clostridial Neurotoxin

ABSTRACTAxons and dendrites are long and often ramified neurites that need particularly intense plasma membrane (PM) expansion during the development of the nervous system. Neurite growth depends on non-fusogenic Sec22b–Stx1 SNARE complexes at endoplasmic reticulum (ER)–PM contacts. Here, we show that Sec22b interacts with members of the extended synaptotagmin (E-Syt) family of ER lipid transfer proteins (LTPs), and this interaction depends on the longin domain of Sec22b. Overexpression of E-Syts stabilizes Sec22b–Stx1 association, whereas silencing of E-Syts has the opposite effect. Overexpression of wild-type E-Syt2, but not mutants unable to transfer lipids or attach to the ER, increase the formation of axonal filopodia and ramification of neurites in developing neurons. This effect is inhibited by a clostridial neurotoxin cleaving Stx1, and expression of the Sec22b longin domain and a Sec22b mutant with an extended linker between the SNARE and transmembrane domains. We conclude that Sec22b–Stx1 ER–PM contact sites contribute to PM expansion by interacting with LTPs, such as E-Syts.This article has an associated First Person interview with the first author of the paper.

scholarly journals Sensitisation to lipid transfer proteins in pollen – allergic adults with food allergy

2020 ◽  
Vol 37 (4) ◽  
pp. 508-512
Author(s):  
Adam Wawrzeńczyk ◽  
Magdalena Żbikowska-Gotz ◽  
Anna Wawrzenczyk ◽  
Zbigniew Bartuzi
Keyword(s):  
Food Allergy ◽  
Lipid Transfer ◽  
Lipid Transfer Proteins

Characterization of asparagus allergens: A relevant role of lipid transfer proteins

2002 ◽  
Vol 110 (5) ◽  
pp. 790-796 ◽  
Author(s):  
Araceli Díaz-Perales ◽  
Ana I. Tabar ◽  
Rosa Sánchez-Monge ◽  
Blanca E. García ◽  
Belén Gómez ◽  
...  
Keyword(s):  
Lipid Transfer ◽  
Lipid Transfer Proteins ◽  
Relevant Role

Wheat IgE-Mediated Food Allergy in European Patients: α-Amylase Inhibitors, Lipid Transfer Proteins and Low-Molecular-Weight Glutenins

2007 ◽  
Vol 144 (1) ◽  
pp. 10-22 ◽  
Author(s):  
Elide A. Pastorello ◽  
Laura Farioli ◽  
Amedeo Conti ◽  
Valerio Pravettoni ◽  
Simona Bonomi ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Food Allergy ◽  
Low Molecular Weight ◽  
Lipid Transfer ◽  
Lipid Transfer Proteins ◽  
Ige Mediated ◽  
Amylase Inhibitors

The role of lipid transfer proteins in plasma lipoprotein metabolism

1987 ◽  
Vol 113 (2) ◽  
pp. 538-542 ◽  
Author(s):  
Philip J Barter ◽  
Garry J Hopkins ◽  
Ying C Ha
Keyword(s):  
Lipoprotein Metabolism ◽  
Plasma Lipoprotein ◽  
Lipid Transfer ◽  
Lipid Transfer Proteins

scholarly journals The Role of Lipid Transfer Proteins as Food and Pollen Allergens Outside the Mediterranean Area

2021 ◽  
Vol 21 (2) ◽  
Author(s):  
Stephan Scheurer ◽  
Ronald van Ree ◽  
Stefan Vieths
Keyword(s):  
Mediterranean Area ◽  
Food Allergies ◽  
Lipid Transfer ◽  
Pollen Allergens ◽  
Lipid Transfer Proteins ◽  
High Exposure ◽  
The Mediterranean ◽  
Specific Lipid ◽  
Pru P 3

Abstract Purpose of Review To provide an overview of the prevalence and clinical manifestation of non-specific lipid transfer proteins (LTP)-mediated allergies outside the Mediterranean area and to address potential reasons for the different geographical significance of LTP-driven allergies. Recent Findings LTPs are major allergens in the Mediterranean area, which frequently can elicit severe reactions. Pru p 3 the LTP from peach is reported as genuine allergen and is considered a prototypic marker for LTP-mediated allergies. However, both food and pollen LTP allergies exist outside the Mediterranean area, but with lower clinical significance, different immunogenicity, and less clarified role. Summary Evidence has been reported that in areas with high exposure to pollen, in particular to mugwort, pollen-derived LTPs can act as a primary sensitizer to trigger secondary food allergies. Co-sensitization to unrelated allergens might be causative for less severe reactions in response to LTPs. However, the reason for the geographical different sensitization patterns to LTPs remains unclear.

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