scholarly journals Associations between polymorphisms of the ACYP2 gene and Liver cancer risk: A case‐control study and meta‐analysis

2019 ◽  
Vol 7 (7) ◽  
Author(s):  
Wenhui Zhao ◽  
Xu Liu ◽  
Zhendong Yu ◽  
Zichao Xiong ◽  
Jiamin Wu ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Control Study

scholarly journals The association of POLR2E rs3787016 polymorphism and cancer risk: a Chinese case–control study and meta-analysis

2018 ◽  
Vol 38 (6) ◽  
Author(s):  
Bifeng Chen ◽  
Shang Wang ◽  
Guangxin Ma ◽  
Jin Han ◽  
Jingli Zhang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lung Cancer ◽  
Liver Cancer ◽  
Cancer Risk ◽  
Cancer Patients ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
A Genome ◽  
Control Study

How single nucleotide polymorphisms in long non-coding RNAs are involved in cancer susceptibility remains poorly understood. We hypothesized that polymerase II polypeptide E (POLR2E) rs3787016 polymorphism, identified in a genome-wide association study of prostate cancer, might be a common genetic risk factor for cancer risk. To address this issue, we here conducted a case–control study to investigate the association of POLR2E rs3787016 polymorphism with risk of liver and lung cancer (including 800 normal controls, 480 liver cancer patients, and 550 lung cancer patients), followed by a meta-analysis. The genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism and confirmed by sequencing. Although no significant association was found for rs3787016 with risk of liver or lung cancer, the further stratified analysis identified that rs3787016 contributed to liver cancer risk particularly for over than 60 years individuals who drink. Moreover, the meta-analysis demonstrated that rs3787016 was associated with overall cancer risk and prostate cancer risk. Collectively, the POLR2E rs3787016 polymorphism may be a valuable biomarker for cancer predisposition.

AA genotype of cyclin D1 G870A polymorphism increases breast cancer risk: Findings of a case‐control study and meta‐analysis

2019 ◽  
Vol 120 (10) ◽  
pp. 16452-16466 ◽  
Author(s):  
Naseem Akhter ◽  
Faisal Abdulrahman Alzahrani ◽  
Sajad Ahmad Dar ◽  
Mohd Wahid ◽  
Real Sumayya Abdul Sattar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Cyclin D1 ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Control Study
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