scholarly journals Association of XPC Gene Polymorphisms with Colorectal Cancer Risk in a Southern Chinese Population: A Case-Control Study and Meta-Analysis

Genes ◽  
2016 ◽  
Vol 7 (10) ◽  
pp. 73 ◽  
Author(s):  
Rui-Xi Hua ◽  
Jinhong Zhu ◽  
Dan-Hua Jiang ◽  
Shao-Dan Zhang ◽  
Jiang-Bo Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Colorectal Cancer Risk ◽  
Southern Chinese ◽  
Control Study

Dietary B vitamin and methionine intakes and risk for colorectal cancer: a case–control study in China

2020 ◽  
Vol 123 (11) ◽  
pp. 1277-1289 ◽  
Author(s):  
Chu-Yi Huang ◽  
Alinuer Abulimiti ◽  
Xin Zhang ◽  
Xiao-Li Feng ◽  
Hong Luo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Chinese Population ◽  
Case Control Study ◽  
Case Control ◽  
B Vitamins ◽  
Colorectal Cancer Risk ◽  
Vitamin B ◽  
Nucleotide Synthesis ◽  
Control Study

AbstractB vitamins (including folate, vitamin B2, vitamin B6 and vitamin B12) and methionine are essential for methylation reactions, nucleotide synthesis, DNA stability and DNA repair. However, epidemiological evidence among Chinese populations is limited. The objective of this study was to evaluate B vitamins and methionine in relation to colorectal cancer risk in a Chinese population. A case–control study was conducted from July 2010 to April 2019. A total of 2502 patients with colorectal cancer were recruited along with 2538 age- (5-year interval) and sex-matched controls. Dietary data were collected using a validated FFQ. Multivariable logistic regression was used to assess OR and 95 % CI. The intake of folate, vitamin B2, vitamin B6 and vitamin B12 was inversely associated with colorectal cancer risk. The multivariable OR for the highest quartile v. the lowest quartile were 0·62 (95 % CI 0·51, 0·74; Ptrend < 0·001) for folate, 0·46 (95 % CI 0·38, 0·55; Ptrend < 0·001) for vitamin B2, 0·55 (95 % CI 0·46, 0·76; Ptrend < 0·001) for vitamin B6 and 0·72 (95 % CI 0·60, 0·86; Ptrend < 0·001) for vitamin B12. No statistically significant association was found between methionine intake and colorectal cancer risk. Stratified analysis by sex showed that the inverse associations between vitamin B12 and methionine intake and colorectal cancer risk were found only among women. This study indicated that higher intake of folate, vitamin B2, vitamin B6 and vitamin B12 was associated with decreased risk of colorectal cancer in a Chinese population.

MYELOPEROXIDASE GENE POLYMORPHISMS AND COLORECTAL CANCER RISK: A CASE-CONTROL STUDY IN TAIWAN

Epidemiology ◽  
2005 ◽  
Vol 16 (5) ◽  
pp. S37 ◽  
Author(s):  
C C. Yeh ◽  
L L. Hsieh ◽  
R Tang ◽  
C R. Chang-Chieh ◽  
R M. Santella
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Gene Polymorphisms ◽  
Case Control Study ◽  
Case Control ◽  
Colorectal Cancer Risk ◽  
Control Study

scholarly journals Choline and Betaine Intake and Colorectal Cancer Risk in Chinese Population: A Case-Control Study

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0118661 ◽  
Author(s):  
Min-Shan Lu ◽  
Yu-Jing Fang ◽  
Zhi-Zhong Pan ◽  
Xiao Zhong ◽  
Mei-Chun Zheng ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Chinese Population ◽  
Case Control Study ◽  
Case Control ◽  
Colorectal Cancer Risk ◽  
Control Study

scholarly journals The Dietary Inflammatory Index Is Positively Associated with Colorectal Cancer Risk in a Chinese Case-Control Study

Nutrients ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 232
Author(s):  
Alinuer Abulimiti ◽  
Xin Zhang ◽  
Nitin Shivappa ◽  
James R. Hébert ◽  
Yu-Jing Fang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Chinese Population ◽  
Case Control Study ◽  
Case Control ◽  
Colorectal Cancer Risk ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index ◽  
Inflammatory Score ◽  
Control Study

Diet may modulate chronic inflammation. The aim of this study is to investigate whether the dietary inflammatory index (DII®) was associated with the risk of colorectal cancer in a Chinese population. A case-control study was conducted from July 2010 to April 2019, in Guangzhou, China. A total of 2502 eligible cases were recruited along with 2538 age- (5-year interval) and sex-matched controls. Dietary data derived from a validated food frequency questionnaire were used to calculate the energy-adjusted DII (E-DII) scores. Odds ratios (ORs) and 95% confidence intervals (CIs) for colorectal cancer risk were estimated using unconditional logistic regression models. In this study, E-DII scores ranged from −5.96 (the most anti-inflammatory score) to +6.01 (the most pro-inflammatory score). A positive association was found between the E-DII and colorectal cancer risk, with the OR = 1.40 (95% CI 1.16, 1.68; Ptrend < 0.01) for the highest E-DII quartile compared with the lowest quartile after adjusting for potential confounders. When stratified based on cancer subsite, sex, body mass index, and smoking status, significant associations were not observed in women or underweight individuals. Results from this study confirmed that a higher E-DII score was associated with an increased risk of colorectal cancer in a Chinese population.

scholarly journals Carbohydrate, dietary glycaemic index and glycaemic load, and colorectal cancer risk: a case–control study in China

2018 ◽  
Vol 119 (8) ◽  
pp. 937-948 ◽  
Author(s):  
Jing Huang ◽  
Yu-Jing Fang ◽  
Ming Xu ◽  
Hong Luo ◽  
Nai-Qi Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Chinese Population ◽  
Case Control Study ◽  
Glycaemic Index ◽  
Case Control ◽  
Colorectal Cancer Risk ◽  
Total Carbohydrate ◽  
Glycaemic Load ◽  
Control Study

AbstractA carbohydrate-rich diet results in hyperglycaemia and hyperinsulinaemia; it may further induce the carcinogenesis of colorectal cancer. However, epidemiological evidence among Chinese population is quite limited. The aim of this study was to investigate total carbohydrate, non-fibre carbohydrate, total fibre, starch, dietary glycaemic index (GI) and glycaemic load (GL) in relation to colorectal cancer risk in Chinese population. A case–control study was conducted from July 2010 to April 2017, recruiting 1944 eligible colorectal cancer cases and 2027 age (5-year interval) and sex frequency-matched controls. Dietary information was collected by using a validated FFQ. The OR and 95 % CI of colorectal cancer risk were assessed by multivariable logistic regression models. There was no clear association between total carbohydrate intake and colorectal cancer risk. The adjusted OR was 0·85 (95 % CI 0·70, 1·03,Ptrend=0·08) comparing the highest with the lowest quartile. Total fibre was related to a 53 % reduction in colorectal cancer risk (adjusted ORquartile 4v.10·47; 95 % CI 0·39, 0·58). However, dietary GI was positively associated with colorectal cancer risk, with an adjusted ORquartile 4v.1of 3·10 (95 % CI 2·51, 3·85). No significant association was found between the intakes of non-fibre carbohydrate, starch and dietary GL and colorectal cancer risk. This study indicated that dietary GI was positively associated with colorectal cancer risk, but no evidence supported that total carbohydrate, non-fibre carbohydrate, starch or high dietary GL intake were related to an increased risk of colorectal cancer in a Chinese population.

scholarly journals Association between phytosterol intake and colorectal cancer risk: a case–control study

2017 ◽  
Vol 117 (6) ◽  
pp. 839-850 ◽  
Author(s):  
Jing Huang ◽  
Ming Xu ◽  
Yu-Jing Fang ◽  
Min-Shan Lu ◽  
Zhi-Zhong Pan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Chinese Population ◽  
Case Control Study ◽  
Positive Association ◽  
Case Control ◽  
Colorectal Cancer Risk ◽  
Inverse Association ◽  
Increased Risk ◽  
Control Study

AbstractA study in rodent models showed that phytosterols protected against colon carcinogenesis, probably by inhibiting dysregulated cell cycle progression and inducing cellular apoptosis. However, epidemiological studies on the relationship between phytosterols and colorectal cancer risk are quite limited. The aim of this study was to investigate dietary phytosterol intake in relation to colorectal cancer risk in the Chinese population. A case–control study was conducted from July 2010 to June 2016, recruiting 1802 eligible colorectal cancer cases plus 1813 age (5-year interval) and sex frequency-matched controls. Dietary information was collected by using a validated FFQ. The OR and 95 % CI of colorectal cancer risk were assessed by multivariable logistic regression models. A higher total intake of phytosterols was found to be associated with a 50 % reduction in colorectal cancer risk. After adjusting for various confounders, the OR of the highest quartile intake compared with the lowest quartile intake was 0·50 (95 % CI 0·41, 0·61, Ptrend<0·01) for total phytosterols. An inverse association was also found between the consumption of β-sitosterol, campesterol, campestanol and colorectal cancer risk. However, stigmasterol intake was related to an increased risk of colorectal cancer. No statistically significant association was found between β-sitostanol and colorectal cancer risk. Stratified analysis by sex showed that the positive association of stigmasterol intake with colorectal cancer risk was found only in women. These data indicated that the consumption of total phytosterols, β-sitosterol, campesterol and campestanol is inversely associated with colorectal cancer risk in a Chinese population.

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