scholarly journals Population genetic analysis of Shaanxi male Han Chinese population reveals genetic differentiation and homogenization of East Asians

2020 ◽  
Vol 8 (5) ◽  
Author(s):  
Luyao Li ◽  
Xing Zou ◽  
Guanjun Zhang ◽  
Hongyan Wang ◽  
Yongdong Su ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Genetic Differentiation ◽  
Chinese Population ◽  
Population Genetic ◽  
Han Chinese ◽  
East Asians ◽  
Population Genetic Analysis ◽  
Han Chinese Population

Genetic analysis of LRRK2 in Parkinson's disease in Han Chinese population

2018 ◽  
Vol 72 ◽  
pp. 187.e5-187.e10 ◽  
Author(s):  
Jin-Ru Zhang ◽  
Hong Jin ◽  
Kai Li ◽  
Cheng-Jie Mao ◽  
Ya-Ping Yang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Genetic Analysis ◽  
Chinese Population ◽  
Han Chinese ◽  
Han Chinese Population

scholarly journals GENETIC DIFFERENTIATION OF TWO PHENOTYPES OF PLANTAGO MEDIA L. IN SOUTH TIMAN

2020 ◽  
Author(s):  
Ilya Grigor’yevich Zakhozhiy ◽  
Dmitry Mikhaylovich Shadrin ◽  
Yana Igorevna Pylina ◽  
Ivan Fedorovich Chadin ◽  
Tamara Konstantinovna Golovko
Keyword(s):  
Genetic Analysis ◽  
Genetic Differentiation ◽  
Population Genetic ◽  
Biological Diversity ◽  
Phenotypic Variability ◽  
Issr Markers ◽  
Population Genetic Analysis ◽  
Plantago Media ◽  
Main Components ◽  
Light And Shadow

Background. The investigation of the genetic nature of plant phenotypic variability is of great importance for understanding biological diversity, distribution and adaptation of plants to environmental conditions. The aim of our work was to study the genetic differentiation of two phenotypes of Plantago media in South Timan. Materials and methods. The genetic differentiation of light and shadow phenotypes of Plantago media plants was evaluated using intersimple sequence repeats (ISSR) markers. Results. The population-genetic analysis of 210 loci revealed two clusters, which boundaries coincided with the boundaries between plants of light and shadow phenotypes. The results of the discriminatory analysis of the main components and AMOVA (FST = 0.07, p = 0.001) confirmed that there are statistically significant genetic differences between these phenotypes even though they possess a high genetic similarity. Conclusion. Light and shadow Plantago media phenotypes adapted to different ecological conditions are genetically differentiated. The population genetic analysis using ISSR markers is a sensitive tool for identifying the genetic diversity of phenotypic plant variations formed under the influence of environmental factors.

scholarly journals Genetic Structure and Forensic Feature of 38 X-Chromosome InDels in the Henan Han Chinese Population

2022 ◽  
Vol 12 ◽  
Author(s):  
Lin Zhang ◽  
Zhendong Zhu ◽  
Weian Du ◽  
Shengbin Li ◽  
Changhui Liu
Keyword(s):  
X Chromosome ◽  
Chinese Population ◽  
Population Genetic ◽  
Genetic Relationships ◽  
Han Chinese ◽  
Genetic Studies ◽  
Han Chinese Population ◽  
Han Population ◽  
Indel Markers ◽  
Indel Polymorphisms

Insertion/deletion (InDel) polymorphisms, as ideal forensic markers, show useful characteristics of both SNPs and STRs, such as low mutation rate, short amplicon size and general applicability of genotyping platform, and have been used in human identification, population genetics and biogeographic research in recent years. X-chromosome genetic markers are significant in population genetic studies and indispensable complements in some complex forensic cases. However, the population genetic studies of X-chromosome InDel polymorphisms (X-InDels) still need to be explored. In this study, the forensic utility of a novel panel including 38 X-InDel markers was evaluated in a sample of Han population from Henan province in China. It is observed that the heterozygosities ranged from 0.0054 to 0.6133, and the combined discrimination power was 1–9.18 × 10−17 for males and 1–7.22 × 10−12 for females respectively. The mean exclusion chance in trios and duos were 0.999999319 and 0.999802969 respectively. Multiple biostatistics methods, such as principal component analysis, genetic distances analysis, phylogenetic reconstruction, and structure analysis was used to reveal the genetic relationships among the studied Henan Han group and other 26 reference groups from 1,000 Genomes Project. As expected, the Henan Han population was clustered with East Asian populations, and the most intimate genetic relationships existed in three Han Chinese populations from Henan, Beijing and South China, and showed significant differences compared with other continental groups. These results confirmed the suitability of the 38 X-InDel markers both in individual identification and parentage testing in Han Chinese population, and simultaneously showed the potential application in population genetics.

scholarly journals Association of Lipoprotein (a) variants with risk of cardiovascular disease: a Mendelian randomization study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Juan Xia ◽  
Chunyue Guo ◽  
Kuo Liu ◽  
Yunyi Xie ◽  
Han Cao ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Cardiovascular Disease ◽  
Chinese Population ◽  
Left Ventricular Mass Index ◽  
Mendelian Randomization ◽  
Left Ventricular ◽  
Han Chinese ◽  
Han Chinese Population ◽  
Internal Dimension

Abstract Background There is a well-documented empirical relationship between lipoprotein (a) [Lp(a)] and cardiovascular disease (CVD); however, causal evidence, especially from the Chinese population, is lacking. Therefore, this study aims to estimate the causal association between variants in genes affecting Lp(a) concentrations and CVD in people of Han Chinese ethnicity. Methods Two-sample Mendelian randomization analysis was used to assess the causal effect of Lp(a) concentrations on the risk of CVD. Summary statistics for Lp(a) variants were obtained from 1256 individuals in the Cohort Study on Chronic Disease of Communities Natural Population in Beijing, Tianjin and Hebei. Data on associations between single-nucleotide polymorphisms (SNPs) and CVD were obtained from recently published genome-wide association studies. Results Thirteen SNPs associated with Lp(a) levels in the Han Chinese population were used as instrumental variables. Genetically elevated Lp(a) was inversely associated with the risk of atrial fibrillation [odds ratio (OR), 0.94; 95% confidence interval (95%CI), 0.901–0.987; P = 0.012)], the risk of arrhythmia (OR, 0.96; 95%CI, 0.941–0.990; P = 0.005), the left ventricular mass index (OR, 0.97; 95%CI, 0.949–1.000; P = 0.048), and the left ventricular internal dimension in diastole (OR, 0.97; 95%CI, 0.950–0.997; P = 0.028) according to the inverse-variance weighted method. No significant association was observed for congestive heart failure (OR, 0.99; 95% CI, 0.950–1.038; P = 0.766), ischemic stroke (OR, 1.01; 95%CI, 0.981–1.046; P = 0.422), and left ventricular internal dimension in systole (OR, 0.98; 95%CI, 0.960–1.009; P = 0.214). Conclusions This study provided evidence that genetically elevated Lp(a) was inversely associated with atrial fibrillation, arrhythmia, the left ventricular mass index and the left ventricular internal dimension in diastole, but not with congestive heart failure, ischemic stroke, and the left ventricular internal dimension in systole in the Han Chinese population. Further research is needed to identify the mechanism underlying these results and determine whether genetically elevated Lp(a) increases the risk of coronary heart disease or other CVD subtypes.

scholarly journals Adaptive Evolution of Relish, a Drosophila NF-κB/IκB Protein

Genetics ◽  
2000 ◽  
Vol 154 (3) ◽  
pp. 1231-1238 ◽  
Author(s):  
David J Begun ◽  
Penn Whitley
Keyword(s):  
Immune Response ◽  
Innate Immunity ◽  
Genetic Analysis ◽  
Adaptive Evolution ◽  
Strong Evidence ◽  
Population Genetic ◽  
Microbial Pathogens ◽  
Population Genetic Analysis ◽  
Evolutionary Conflict ◽  
A Site

Abstract NF-κB and IκB proteins have central roles in regulation of inflammation and innate immunity in mammals. Homologues of these proteins also play an important role in regulation of the Drosophila immune response. Here we present a molecular population genetic analysis of Relish, a Drosophila NF-κB/IκB protein, in Drosophila simulans and D. melanogaster. We find strong evidence for adaptive protein evolution in D. simulans, but not in D. melanogaster. The adaptive evolution appears to be restricted to the IκB domain. A possible explanation for these results is that Relish is a site of evolutionary conflict between flies and their microbial pathogens.

Common variants in IL17F gene contributed to the risk of hip osteoarthritis susceptibility in Han Chinese population

2020 ◽  
Vol 23 (8) ◽  
pp. 1050-1056
Author(s):  
Tianyun Zhao ◽  
Chi Ma ◽  
Wei Wang ◽  
Bin Zhao ◽  
Baopin Xie ◽  
...  
Keyword(s):  
Chinese Population ◽  
Hip Osteoarthritis ◽  
Han Chinese ◽  
Common Variants ◽  
Han Chinese Population

scholarly journals Role of CASP7 polymorphisms in noise-induced hearing loss risk in Han Chinese population

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yanmei Ruan ◽  
Jinwei Zhang ◽  
Shiqi Mai ◽  
Wenfeng Zeng ◽  
Lili Huang ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Chinese Population ◽  
Conditional Logistic Regression ◽  
Han Chinese ◽  
Control Group ◽  
Environment Interaction ◽  
Noise Induced Hearing Loss ◽  
Han Chinese Population ◽  
Hearing Thresholds ◽  
Increased Risk

AbstractGenetic factors and gene-environment interaction may play an important role in the development of noise induced hearing loss (NIHL). 191 cases and 191 controls were selected by case–control study. Among them, case groups were screened from workers exposed to noise in binaural high-frequency hearing thresholds greater than 25 dB (A). Workers with hearing thresholds ≤ 25 dB (A) in any binaural frequency band were selected to the control group, based on matching factors such as age, exposure time to noise, and operating position. The blood samples from two groups of workers were subjected to DNA extraction and SNP sequencing of CASP3 and CASP7 genes using the polymerase chain reaction ligase detection reaction method. Conditional logistic regression correction was used to analyze the genetic variation associated with susceptibility to NIHL. There was an association between rs2227310 and rs4353229 of the CASP7 gene and the risk of NIHL. Compared with the GG genotype, the CC genotype of rs2227310 reduced the risk of NIHL. Compared with CC genotype, the TT genotype of rs4353229 reduced the risk of NIHL. Workers carrying the rs2227310GG and rs4353229CC genotype had an increased risk of NIHL compared to workers without any high-risk genotype. There were additive interaction and multiplication interaction between CASP7rs2227310 and CNE, and the same interaction between CASP7rs4353229 and CNE. The interaction between the CASP7 gene and CNE significantly increased the risk of NIHL. The genetic polymorphisms of CASP7rs2227310GG and CASP7rs4353229CC were associated with an increased risk of NIHL in Han Chinese population and have the potential to act as biomarkers for noise-exposed workers.

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