scholarly journals Corrigendum: Molecular targeting therapies for neuroblastoma: Progress and challenges

2021 ◽  
Keyword(s):  
Molecular Targeting

scholarly journals Molecular Targeting of VEGF with a Suramin Fragment–DOCA Conjugate by Mimicking the Action of Low Molecular Weight Heparins

Biomolecules ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 46
Author(s):  
Jooho Park ◽  
Tae-Bong Kang ◽  
Ji-Hong Lim ◽  
Hyung-Sik Won
Keyword(s):  
Therapeutic Potential ◽  
Umbilical Vein ◽  
Pharmaceutical Research ◽  
Molecular Targeting ◽  
Drug Candidate ◽  
Heparin Binding ◽  
Vegf Inhibitor ◽  
Acid Conjugate ◽  
Pathogenic Action ◽  
Umbilical Vein Endothelial Cells

Molecular targeting of growth factors has shown great therapeutic potential in pharmaceutical research due to their roles in pathological conditions. In the present study, we developed a novel suramin fragment and deoxycholic acid conjugate (SFD) that exhibited the potential to bind to the heparin-binding site (HBD) of vascular endothelial growth factor (VEGF) and to inhibit its pathogenic action for the first time. Notably, SFD was optimally designed for binding to the HBD of VEGF using the naphthalenetrisulfonate group, allowing to observe its excellent binding efficacy in a surface plasmon resonance (SPR) study, showing remarkable binding affinity (KD = 3.8 nM) as a small molecule inhibitor. In the tubular formation assay, it was observed that SFD could bind to HBD and exhibit antiangiogenic efficacy by inhibiting VEGF, such as heparins. The cellular treatment of SFD resulted in VEGF-inhibitory effects in human umbilical vein endothelial cells (HUVECs). Therefore, we propose that SFD can be employed as a novel drug candidate to inhibit the pathophysiological action of VEGF in diseases. Consequently, SFD, which has a molecular structure optimized for binding to HBD, is put forward as a new chemical VEGF inhibitor.

scholarly journals Imaging and treatment of brain tumors through molecular targeting: recent clinical advances

2021 ◽  
pp. 109842
Author(s):  
Fulvio Zaccagna ◽  
James T. Grist ◽  
Natale Quartuccio ◽  
Frank Riemer ◽  
Francesco Fraioli ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Molecular Targeting ◽  
Clinical Advances
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