Drug delivery systems designed to overcome antimicrobial resistance

2019 ◽  
Vol 39 (6) ◽  
pp. 2343-2396 ◽  
Author(s):  
Thanh‐Nhat Pham ◽  
Pauline Loupias ◽  
Alexandra Dassonville‐Klimpt ◽  
Pascal Sonnet
Keyword(s):  
Drug Delivery ◽  
Antimicrobial Resistance ◽  
Drug Delivery Systems ◽  
Delivery Systems

scholarly journals Incorporation of Antibiotics into Solid Lipid Nanoparticles: A Promising Approach to Reduce Antibiotic Resistance Emergence

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1251
Author(s):  
Lide Arana ◽  
Lucia Gallego ◽  
Itziar Alkorta
Keyword(s):  
Drug Delivery ◽  
Antibiotic Resistance ◽  
Antimicrobial Resistance ◽  
Solid Lipid Nanoparticles ◽  
Drug Delivery Systems ◽  
Lipid Nanoparticles ◽  
Resistance Mechanisms ◽  
Delivery Systems ◽  
Solid Lipid Nanoparticle ◽  
Solid Lipid

Antimicrobial resistance is one of the biggest threats to global health as current antibiotics are becoming useless against resistant infectious pathogens. Consequently, new antimicrobial strategies are urgently required. Drug delivery systems represent a potential solution to improve current antibiotic properties and reverse resistance mechanisms. Among different drug delivery systems, solid lipid nanoparticles represent a highly interesting option as they offer many advantages for nontoxic targeted drug delivery. Several publications have demonstrated the capacity of SLNs to significantly improve antibiotic characteristics increasing treatment efficiency. In this review article, antibiotic-loaded solid lipid nanoparticle-related works are analyzed to summarize all information associated with applying these new formulations to tackle the antibiotic resistance problem. The main antimicrobial resistance mechanisms and relevant solid lipid nanoparticle characteristics are presented to later discuss the potential of these nanoparticles to improve current antibiotic treatment characteristics and overcome antimicrobial resistance mechanisms. Moreover, solid lipid nanoparticles also offer new possibilities for other antimicrobial agents that cannot be administrated as free drugs. The advantages and disadvantages of these new formulations are also discussed in this review. Finally, given the progress of the studies carried out to date, future directions are discussed.

Antimicrobial Resistance and Antimicrobial Nanomaterials

2021 ◽  
pp. 1-28
Author(s):  
Muthupandian Saravanan ◽  
Melaku Ashagrie Belete ◽  
Selam Niguse ◽  
Ephrem Tsegay ◽  
Tadele Araya ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Antimicrobial Resistance ◽  
Drug Delivery Systems ◽  
New Technology ◽  
Modern Medicine ◽  
Delivery Systems ◽  
Inorganic Nanoparticles ◽  
Social Burden ◽  
Conventional Drug ◽  
Global Issue

Back in the mid-nineties, the discovery of antimicrobials denoted a profound and remarkable achievement in medicine which was capable of saving lives. However, recently, antimicrobial resistance became a major global issue facing modern medicine and significantly increased among bacteria, fungi, and viruses which results in reduced efficacy of many clinically important and lifesaving antimicrobials. The growing rise of antimicrobial resistance inflicts a remarkable economic and social burden on the health care system globally. The replacement of conventional antimicrobials by new technology to counteract and lessen antimicrobial resistance is currently ongoing. Nanotechnology is an advanced approach to overcome challenges of such resisted conventional drug delivery systems mainly based on the development and fabrication of nanoparticulate structures. Numerous forms of nanoparticulate systems have been discovered and tried as prospective drug delivery systems, comprising organic and inorganic nanoparticles.

Nanoemulsion Delivery Systems for Enhanced Efficacy of Antimicrobials and Essential Oils

2022 ◽  
Author(s):  
Celine Renea Garcia ◽  
Muhammad H. Malik ◽  
Sujit Biswas ◽  
Vincent H. Tam ◽  
Kendra P Rumbaugh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Antimicrobial Resistance ◽  
Infectious Diseases ◽  
Essential Oils ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Optimal Drug

The ever-growing threat of new and existing infectious diseases in combination with antimicrobial resistance requires the need for innovative and effective forms of drug delivery. Optimal drug delivery systems for...

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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