scholarly journals Fibrin‐based biomaterial systems to enhance anterior cruciate ligament healing

2020 ◽  
Author(s):  
Grant Scull ◽  
Matthew B. Fisher ◽  
Ashley C. Brown
Keyword(s):  
Anterior Cruciate Ligament ◽  
Cruciate Ligament ◽  
Ligament Healing ◽  
Anterior Cruciate

Medial collateral knee ligament healing: Combined medial collateral and anterior cruciate ligament injuries studied in rabbits

1997 ◽  
Vol 68 (2) ◽  
pp. 142-148 ◽  
Author(s):  
Savio L-Y Woo ◽  
Christopher Niyibizi ◽  
John Matyas ◽  
Karl Kavalkovich ◽  
Colleen Weaver-Green ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
Cruciate Ligament ◽  
Ligament Injuries ◽  
Knee Ligament ◽  
Anterior Cruciate Ligament Injuries ◽  
Ligament Healing ◽  
Anterior Cruciate

MRI of Anterior Cruciate Ligament Healing

1996 ◽  
Vol 20 (2) ◽  
pp. 317-321 ◽  
Author(s):  
Hidetoshi Ihara ◽  
Megumi Miwa ◽  
Keizo Deya ◽  
Kenji Torisu
Keyword(s):  
Anterior Cruciate Ligament ◽  
Cruciate Ligament ◽  
Ligament Healing ◽  
Anterior Cruciate

scholarly journals Image Guided Injection of Anterior Cruciate Ligament Tears with Autologous Bone Marrow Concentrate and Platelets: Midterm Analysis from A Randomized Controlled Trial

2022 ◽  
Vol 3 (SP2) ◽  
pp. e7-e20
Author(s):  
Christopher Centeno ◽  
Matthew Lucas ◽  
Ian Stemper ◽  
Ehren Dodson
Keyword(s):  
Bone Marrow ◽  
Anterior Cruciate Ligament ◽  
Exercise Therapy ◽  
Cruciate Ligament ◽  
Post Treatment ◽  
Percutaneous Injection ◽  
Bone Marrow Concentrate ◽  
Recent Emergence ◽  
Ligament Healing ◽  
Anterior Cruciate

Background: There has been a recent emergence in the use of orthobiologics, including platelet-rich plasma (PRP) and bone marrow concentrate (BMC), in the treatment of various musculoskeletal conditions. The goal of this study was to determine if injection of BMC and platelet products into partial and full-thickness anterior cruciate ligament (ACL) tears can facilitate primary ligament healing in patients failing conservative care, resulting in improved outcomes compared to exercise therapy.Methods: Patients were randomized to either exercise therapy or percutaneous injection of autologous BMC with PRP and platelet lysate into the ACL under fluoroscopic guidance. Pain and function were assessed at baseline and at 1, 3, 6, 12, and 24 months. Baseline and 6-month post-treatment magnetic resonance imaging (MRI) were obtained to evaluate interval healing. Laxity was assessed using the Telos device.Results: There was significant improvement in functional outcomes in the BMC group, compared to base-line for LEFS at time points 3 up to 24 months s = 0.000000005), and significant improvement in pain in the BMC group at 6 (p = 0.00054), 12 (p = 0.00127), and 24 months (p = 0.002). There was no significant improvement in pain or function at any time point in the exercise therapy group. There was significant improvement in ACL MRI ImageJ quantitative assessment in the BMC group (p = 0.001) and no difference in the exercise group (p > 0.05). No serious adverse events were reported.Conclusion: Autologous BMC and platelet product injection into ACL tears improved patient function compared to exercise, observed through 24 months. Patients treated with BMC demonstrated quantitative improvements in post-treatment MRI scans suggestive of interval ligament healing.

scholarly journals Biologic agents for anterior cruciate ligament healing: A systematic review

2016 ◽  
Vol 7 (9) ◽  
pp. 592 ◽  
Author(s):  
Berardo Di Matteo ◽  
Markus Loibl ◽  
Luca Andriolo ◽  
Giuseppe Filardo ◽  
Johannes Zellner ◽  
...  
Keyword(s):  
Systematic Review ◽  
Anterior Cruciate Ligament ◽  
Cruciate Ligament ◽  
Biologic Agents ◽  
Ligament Healing ◽  
Anterior Cruciate

Anterior Cruciate Ligament Healing and Advances in Imaging

2013 ◽  
Vol 32 (1) ◽  
pp. 13-20 ◽  
Author(s):  
Stephen J. Rabuck ◽  
Michael G. Baraga ◽  
Freddie H. Fu
Keyword(s):  
Anterior Cruciate Ligament ◽  
Cruciate Ligament ◽  
Ligament Healing ◽  
Anterior Cruciate

Higher Gene Expression of Healing Factors in Anterior Cruciate Ligament Remnant in Acute Anterior Cruciate Ligament Tear

2018 ◽  
Vol 46 (7) ◽  
pp. 1583-1591 ◽  
Author(s):  
João Victor Novaretti ◽  
Diego Costa Astur ◽  
Davi Casadio ◽  
Alexandre Pedro Nicolini ◽  
Alberto de Castro Pochini ◽  
...  
Keyword(s):  
Gene Expression ◽  
Anterior Cruciate Ligament ◽  
Cruciate Ligament ◽  
Intermediate Group ◽  
Remnant Preservation ◽  
Acute Group ◽  
Microscopic Evaluation ◽  
Ligament Healing ◽  
Anterior Cruciate ◽  
Time From Injury

Background: Anterior cruciate ligament (ACL) reconstruction with remnant preservation has been described and related to potential advantages. Literature is lacking regarding gene expression of potential factors related to ligament healing in the ACL remnant and its relation to time from injury. Hypothesis: The mRNA expression of ligament healing factors in the ACL remnant would be higher in acute tears (<3 months from injury) than in intermediate (3-12 months) and chronic (>12 months) injuries. Study Design: Controlled laboratory study. Methods: Gene expression of 21 genes related to ligament healing factors was analyzed in 46 ACL remnants biopsied during surgical reconstruction with quantitative real-time polymerase chain reaction technique. Specimens were divided into 3 groups according to time from injury: acute (<3 months from injury; n = 19), intermediate (3-12 months; n = 12), and chronic (>12 months; n = 15). Histological and immunohistochemical evaluation was performed by analysis of hematoxylin and eosin, CD-34, and S-100 staining. Results: Expression of COL1A1, COL1A2, COL3A1, COL5A1, COL5A2, COL12A1, LOX, PLOD1, and TNC genes in ACL remnant was greater in acute compared with chronic injuries. COL1A1, COL5A1, COL12A1, and TNC genes were also expressed more in the acute group compared with the intermediate group. Furthermore, expression of the genes COL1A1 and COL5A2 was significantly higher in female than in male patients. No difference in the number of blood vessels and mechanoreceptors among groups was observed in the microscopic evaluation. Conclusion: The present study demonstrates that expression of COL1A1, COL1A2, COL3A1, COL5A1, COL5A2, COL12A1, LOX, PLOD1, and TNC genes in ACL remnant is greater in acute (<3 months from injury) compared with chronic (>12 months) injuries. Furthermore, COL1A1, COL5A1, COL12A1, and TNC genes were expressed more in the acute group compared with the intermediate group (3-12 months from injury). Clinical Relevance: ACL reconstructions with remnant preservation should be performed in patients with acute injuries, as in these cases the ACL remnant may present the greatest healing potential.

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