scholarly journals Vesicular Acetylcholine Transporter Alters Cholinergic Tone and Synaptic Plasticity in DYT1 Dystonia

2021 ◽  
Author(s):  
Annalisa Tassone ◽  
Giuseppina Martella ◽  
Maria Meringolo ◽  
Valentina Vanni ◽  
Giuseppe Sciamanna ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Vesicular Acetylcholine Transporter ◽  
Dyt1 Dystonia ◽  
Cholinergic Tone

scholarly journals Inhibition of Endoplasmic Reticulum Stress Reverses Synaptic Plasticity Deficits in Striatum of DYT1 Dystonia Mice

2021 ◽  
Author(s):  
Huaying Cai ◽  
Linhui Ni ◽  
Xingyue Hu ◽  
Xianjun Ding
Keyword(s):  
Endoplasmic Reticulum ◽  
Synaptic Plasticity ◽  
Er Stress ◽  
Critical Role ◽  
Stress Protein ◽  
Long Term Potentiation ◽  
Research Field ◽  
Protein Levels ◽  
Dyt1 Dystonia

Abstract Background & objectiveStriatal plasticity alterations caused by endoplasmic reticulum (ER) stress is supposed to be critically involved in the mechanism of DYT1 dystonia. In the current study, we expanded this research field by investigating the critical role of ER stress underlying synaptic plasticity impairment imposed by mutant heterozygous Tor1a+/- in a DYT1 dystonia mouse model.Methods & resultsLong-term depression (LTD) was failed to be induced, while long-term potentiation (LTP) was further strengthened in striatal spiny neurons (SPNs) from the Tor1a+/- DYT1 dystonia mice. Spine morphology analyses revealed a significant increase of both number of mushroom type spines and spine width in Tor1a+/- SPNs. In addition, increased AMPA receptor function and the reduction of NMDA/AMPA ratio in the postsynaptic of Tor1a+/- SPNs was observed, along with increased ER stress protein levels in Tor1a+/- striatum. Notably, ER stress inhibitors, tauroursodeoxycholic acid (TUDCA), could rescue LTD as well as AMPA currents.ConclusionThe current study illustrated the role of ER stress in mediating structural and functional plasticity alterations in Tor1a+/- SPNs. Inhibition of the ER stress by TUDCA is beneficial in reversing the deficits at the cellular and molecular levels. Remedy of dystonia associated neurological and motor functional impairment by ER stress inhibitors could be a recommendable therapeutic agent in clinical practice.

scholarly journals Erratum to: Striatal and cerebellar vesicular acetylcholine transporter expression is disrupted in human DYT1 dystonia

Brain ◽  
2021 ◽  
Author(s):  
Joachim Mazere ◽  
Bixente Dilharreguy ◽  
Gwenaëlle Catheline ◽  
Marie Vidailhet ◽  
Marc Deffains ◽  
...  
Keyword(s):  
Vesicular Acetylcholine Transporter ◽  
Dyt1 Dystonia ◽  
Transporter Expression

scholarly journals Impairment of bidirectional synaptic plasticity in the striatum of a mouse model of DYT1 dystonia: role of endogenous acetylcholine

Brain ◽  
2009 ◽  
Vol 132 (9) ◽  
pp. 2336-2349 ◽  
Author(s):  
Giuseppina Martella ◽  
Annalisa Tassone ◽  
Giuseppe Sciamanna ◽  
Paola Platania ◽  
Dario Cuomo ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Mouse Model ◽  
Dyt1 Dystonia

scholarly journals Strength of cholinergic tone dictates the polarity of dopamine D2 receptor modulation of striatal cholinergic interneuron excitability in DYT1 dystonia

2017 ◽  
Vol 295 ◽  
pp. 162-175 ◽  
Author(s):  
Mariangela Scarduzio ◽  
Chelsea N. Zimmerman ◽  
Karen L. Jaunarajs ◽  
Qin Wang ◽  
David G. Standaert ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Dopamine D2 ◽  
Dyt1 Dystonia ◽  
Receptor Modulation ◽  
Cholinergic Tone ◽  
Cholinergic Interneuron

Regional specificity of synaptic plasticity deficits in a knock-in mouse model of DYT1 dystonia

2014 ◽  
Vol 65 ◽  
pp. 124-132 ◽  
Author(s):  
G. Martella ◽  
M. Maltese ◽  
R. Nisticò ◽  
T. Schirinzi ◽  
G. Madeo ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Mouse Model ◽  
Dyt1 Dystonia ◽  
Regional Specificity

scholarly journals Anticholinergic drugs rescue synaptic plasticity in DYT1 dystonia: Role of M1muscarinic receptors

2014 ◽  
Vol 29 (13) ◽  
pp. 1655-1665 ◽  
Author(s):  
Marta Maltese ◽  
Giuseppina Martella ◽  
Graziella Madeo ◽  
Irene Fagiolo ◽  
Annalisa Tassone ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Anticholinergic Drugs ◽  
Dyt1 Dystonia
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