Parkinson's Disease, NOTCH3 Genetic Variants, and White Matter Hyperintensities

2020 ◽  
Vol 35 (11) ◽  
pp. 2090-2095
Author(s):  
Joel Ramirez ◽  
Allison A. Dilliott ◽  
Malcolm A. Binns ◽  
David P. Breen ◽  
Emily C. Evans ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
Genetic Variants ◽  
White Matter Hyperintensities

White matter hyperintensities as a predictor of freezing of gait in Parkinson's disease

2019 ◽  
Vol 66 ◽  
pp. 105-109 ◽  
Author(s):  
Seok Jong Chung ◽  
Yang Hyun Lee ◽  
Han Soo Yoo ◽  
Jungsu S. Oh ◽  
Jae Seung Kim ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Freezing Of Gait

Effect of olfactory impairment and white matter hyperintensities on cognition in Parkinson's disease

2016 ◽  
Vol 24 ◽  
pp. 95-99 ◽  
Author(s):  
Jee Hyun Ham ◽  
Jae Jung Lee ◽  
Mun-Kyung Sunwoo ◽  
Jin Yong Hong ◽  
Young H. Sohn ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Olfactory Impairment

scholarly journals White matter hyperintensities: a marker for apathy in Parkinson’s disease without dementia?

2020 ◽  
Vol 7 (9) ◽  
pp. 1692-1701
Author(s):  
Yu Zhang ◽  
Guo yong Zhang ◽  
Zi en Zhang ◽  
An qi He ◽  
Jing Gan ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
White Matter Hyperintensities

Brain-Area Specific White Matter Hyperintensities: Associations to Falls in Parkinson’s Disease

2018 ◽  
Vol 8 (3) ◽  
pp. 455-462 ◽  
Author(s):  
Meltem Ciliz ◽  
Jennifer Sartor ◽  
Tobias Lindig ◽  
Andrea Pilotto ◽  
Eva Schäffer ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Brain Area

White matter hyperintensities, cerebrospinal amyloid-β and dementia in Parkinson's disease

2016 ◽  
Vol 367 ◽  
pp. 284-290 ◽  
Author(s):  
Yaroslau Compta ◽  
Mariateresa Buongiorno ◽  
Núria Bargalló ◽  
Francesc Valldeoriola ◽  
Esteban Muñoz ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Amyloid Β

White Matter Hyperintensities and Mild Cognitive Impairment in Parkinson's Disease

2015 ◽  
Vol 25 (5) ◽  
pp. 754-760 ◽  
Author(s):  
Elijah Mak ◽  
Michael G. Dwyer ◽  
Deepa P. Ramasamy ◽  
Wing Lok Au ◽  
Louis C.S. Tan ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
White Matter Hyperintensities

scholarly journals White Matter Hyperintensities and Cognitive Decline in de Novo Parkinson’s Disease Patients

2017 ◽  
Author(s):  
Mahsa Dadar ◽  
Yashar Zeighami ◽  
Yvonne Yau ◽  
Seyed-Mohammad Fereshtehnejad ◽  
Josefina Maranzano ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
Cognitive Decline ◽  
White Matter Hyperintensities ◽  
De Novo ◽  
Cognitive Test ◽  
Cortical Thinning

AbstractObjectiveWhite Matter Hyperintensities (WMHs) are associated with cognitive decline in normative aging and Alzheimer’s disease. However, the pathogenesis of cognitive decline in Parkinson’s disease (PD) is not directly related to vascular causes, and therefore the role of WMHs in PD remains unclear. If WMH has a higher impact on cognitive decline in PD, vascular pathology should be assessed and treated with a higher priority in this population. Here we investigate whether WMH leads to increased cognitive decline in PD, and if these effects relate to cortical thinningMethodsTo investigate the role of WMHs in PD, it is essential to study recently-diagnosed/non-treated patients.De novoPD patients and age-matched controls (NPD=365,NControl=174) with FLAIR/T2-weighted scans at baseline were selected from Parkinson’s Progression Markers Initiative (PPMI). WMHs and cortical thickness were measured to analyse the relationship between baseline WMHs and future cognitive decline (follow-up:4.09±1.14 years) and cortical thinning (follow-up:1.05±0.10 years).ResultsHigh WMH load (WMHL) at baseline in PD was associated with increased cognitive decline, significantly more than i) PDs with low WMHL and ii) controls with high WMHL. Furthermore, PD patients with higher baseline WMHL showed more cortical thinning in right frontal lobe than subjects with low WMHL. Cortical thinning of this region also predicted decline in performance on a cognitive test.InterpretationPresence of WMHs inde novoPD patients predicts greater future cognitive decline and cortical thinning than in normal aging. Recognizing WMHs as a potential predictor of cognitive deficit in PD provides an opportunity for timely interventions.

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