scholarly journals Functional Inhibitory Control Dynamics in Impulse Control Disorders in Parkinson's Disease

2019 ◽  
Vol 35 (2) ◽  
pp. 316-325 ◽  
Author(s):  
Pedro M. Paz‐Alonso ◽  
I. Navalpotro‐Gomez ◽  
P. Boddy ◽  
R. Dacosta‐Aguayo ◽  
M. Delgado‐Alvarado ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Inhibitory Control ◽  
Impulse Control ◽  
Impulse Control Disorders

scholarly journals Inhibitory control dysfunction in parkinsonian impulse control disorders

Brain ◽  
2020 ◽  
Author(s):  
Garance M Meyer ◽  
Charlotte Spay ◽  
Alina Beliakova ◽  
Gabriel Gaugain ◽  
Gianni Pezzoli ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Inhibitory Control ◽  
Response Inhibition ◽  
Impulse Control ◽  
Supplementary Motor Area ◽  
Impulse Control Disorders ◽  
Motor Area ◽  
Beta Activity ◽  
Visuomotor Task

Abstract Impulse control disorders (ICDs) in Parkinson’s disease have been associated with dysfunctions in the control of value- or reward-based responding (choice impulsivity) and abnormalities in mesocorticolimbic circuits. The hypothesis that dysfunctions in the control of response inhibition (action impulsivity) also play a role in Parkinson’s disease ICDs has recently been raised, but the underlying neural mechanisms have not been probed directly. We used high-resolution EEG recordings from 41 patients with Parkinson’s disease with and without ICDs to track the spectral and dynamical signatures of different mechanisms involved in inhibitory control in a simple visuomotor task involving no selection between competing responses and no reward to avoid potential confounds with reward-based decision. Behaviourally, patients with Parkinson’s disease with ICDs proved to be more impulsive than those without ICDs. This was associated with decreased beta activity in the precuneus and in a region of the medial frontal cortex centred on the supplementary motor area. The underlying dynamical patterns pinpointed dysfunction of proactive inhibitory control, an executive mechanism intended to gate motor responses in anticipation of stimulation in uncertain contexts. The alteration of the cortical drive of proactive response inhibition in Parkinson’s disease ICDs pinpoints the neglected role the precuneus might play in higher order executive functions in coordination with the supplementary motor area, specifically for switching between executive settings. Clinical perspectives are discussed in the light of the non-dopaminergic basis of this function.

scholarly journals Risky decision-making and affective features of impulse control disorders in Parkinson’s disease

2017 ◽  
Vol 125 (2) ◽  
pp. 131-143 ◽  
Author(s):  
Alice Martini ◽  
Simon J. Ellis ◽  
James A. Grange ◽  
Stefano Tamburin ◽  
Denise Dal Lago ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Decision Making ◽  
Parkinson's Disease ◽  
Impulse Control ◽  
Impulse Control Disorders ◽  
Risky Decision Making ◽  
Risky Decision

P.5.d.005 Reduced dopamine transporter binding predates impulse control disorders in Parkinson's disease

2013 ◽  
Vol 23 ◽  
pp. S548-S549
Author(s):  
O.A. Van den Heuvel ◽  
C. Vriend ◽  
A.H. Nordbeck ◽  
J. Booij ◽  
Y.D. Van der Werf ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopamine Transporter ◽  
Impulse Control ◽  
Impulse Control Disorders

scholarly journals Clinical and psychopathological factors associated with impulse control disorders in Parkinson's disease

2016 ◽  
Vol 31 (4) ◽  
pp. 231-238 ◽  
Author(s):  
N. Sáez-Francàs ◽  
G. Martí Andrés ◽  
N. Ramírez ◽  
O. de Fàbregues ◽  
J. Álvarez-Sabín ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Impulse Control ◽  
Impulse Control Disorders ◽  
Factors Associated

scholarly journals Impulse Control Disorders in Parkinson's Disease: Epidemiology, Pathogenesis and Therapeutic Strategies

2021 ◽  
Vol 12 ◽  
Author(s):  
Jun-Fang Zhang ◽  
Xi-Xi Wang ◽  
Ya Feng ◽  
Robert Fekete ◽  
Joseph Jankovic ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Broad Spectrum ◽  
Impulse Control ◽  
Compulsive Buying ◽  
Therapeutic Strategies ◽  
Impulse Control Disorders ◽  
Dopaminergic Therapy ◽  
Disease Epidemiology ◽  
Tremendous Impact

Impulse control disorders (ICDs) in Parkinson's disease (PD) are aberrant behavior such as pathological gambling, hypersexuality, binge eating, and compulsive buying, which typically occur as a result of dopaminergic therapy. Numerous studies have focused on the broad spectrum of ICDs-related behaviors and their tremendous impact on patients and their family members. Recent advances have improved our understanding of ICDs. In this review, we discuss the epidemiology, pathogenesis and treatment of ICDs in the setting of PD.

Neuropsychological features of patients with Parkinson’s disease and impulse control disorders

2012 ◽  
Vol 34 (7) ◽  
pp. 1207-1213 ◽  
Author(s):  
Anna Rita Bentivoglio ◽  
Eleonora Baldonero ◽  
Lucia Ricciardi ◽  
Francesca De Nigris ◽  
Antonio Daniele
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Impulse Control ◽  
Impulse Control Disorders
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