scholarly journals Parkinson's disease age at onset genome‐wide association study: Defining heritability, genetic loci, and α‐synuclein mechanisms

2019 ◽  
Vol 34 (6) ◽  
pp. 866-875 ◽  
Author(s):  
Cornelis Blauwendraat ◽  
Karl Heilbron ◽  
Costanza L. Vallerga ◽  
Sara Bandres‐Ciga ◽  
Rainer von Coelln ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Age At Onset ◽  
Genome Wide Association ◽  
Genetic Loci ◽  
Genome Wide

scholarly journals Genome-wide association studies of LRRK2 modifiers of Parkinson's disease

2020 ◽  
Author(s):  
Dongbing Lai ◽  
Babak Alipanahi ◽  
Pierre Fontanillas ◽  
Tae-Hwi Schwantes-An ◽  
Jan Aasly ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Age At Onset ◽  
Genome Wide Association ◽  
P Value ◽  
Polygenic Risk Score ◽  
Polygenic Risk ◽  
Genome Wide

Objective: The aim of this study was to search for genes/variants that modify the effect of LRRK2 mutations in terms of penetrance and age-at-onset of Parkinson's disease. Methods: We performed the first genome-wide association study of penetrance and age-at-onset of Parkinson's disease in LRRK2 mutation carriers (776 cases and 1,103 non-cases at their last evaluation). Cox proportional hazard models and linear mixed models were used to identify modifiers of penetrance and age-at-onset of LRRK2 mutations, respectively. We also investigated whether a polygenic risk score derived from a published genome-wide association study of Parkinson's disease was able to explain variability in penetrance and age-at-onset in LRRK2 mutation carriers. Results: A variant located in the intronic region of CORO1C on chromosome 12 (rs77395454; P-value=2.5E-08, beta=1.27, SE=0.23, risk allele: C) met genome-wide significance for the penetrance model. A region on chromosome 3, within a previously reported linkage peak for Parkinson's disease susceptibility, showed suggestive associations in both models (penetrance top variant: P-value=1.1E-07; age-at-onset top variant: P-value=9.3E-07). A polygenic risk score derived from publicly available Parkinson's disease summary statistics was a significant predictor of penetrance, but not of age-at-onset. Interpretation: This study suggests that variants within or near CORO1C may modify the penetrance of LRRK2 mutations. In addition, common Parkinson's disease associated variants collectively increase the penetrance of LRRK2 mutations.

Linking a genome-wide association study signal to aLRRK2coding variant in Parkinson's disease

2015 ◽  
Vol 31 (4) ◽  
pp. 484-487 ◽  
Author(s):  
Jia Nee Foo ◽  
Sun Ju Chung ◽  
Louis C. Tan ◽  
Herty Liany ◽  
Ho-Sung Ryu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals Web-Based Genome-Wide Association Study Identifies Two Novel Loci and a Substantial Genetic Component for Parkinson's Disease

PLoS Genetics ◽  
2011 ◽  
Vol 7 (6) ◽  
pp. e1002141 ◽  
Author(s):  
Chuong B. Do ◽  
Joyce Y. Tung ◽  
Elizabeth Dorfman ◽  
Amy K. Kiefer ◽  
Emily M. Drabant ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genetic Component ◽  
Genome Wide Association ◽  
Web Based ◽  
Genome Wide

scholarly journals Genome-wide association study reveals genetic risk underlying Parkinson's disease

2009 ◽  
Vol 41 (12) ◽  
pp. 1308-1312 ◽  
Author(s):  
Javier Simón-Sánchez ◽  
Claudia Schulte ◽  
Jose M Bras ◽  
Manu Sharma ◽  
J Raphael Gibbs ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Association Study ◽  
Genetic Risk ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide
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