scholarly journals Genome-wide association study reveals genetic risk underlying Parkinson's disease

2009 ◽  
Vol 41 (12) ◽  
pp. 1308-1312 ◽  
Author(s):  
Javier Simón-Sánchez ◽  
Claudia Schulte ◽  
Jose M Bras ◽  
Manu Sharma ◽  
J Raphael Gibbs ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Association Study ◽  
Genetic Risk ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

2009 ◽  
Vol 41 (12) ◽  
pp. 1303-1307 ◽  
Author(s):  
Wataru Satake ◽  
Yuko Nakabayashi ◽  
Ikuko Mizuta ◽  
Yushi Hirota ◽  
Chiyomi Ito ◽  
...  
Keyword(s):  
Risk Factors ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Association Study ◽  
Genetic Risk ◽  
Genome Wide Association Study ◽  
Genetic Risk Factors ◽  
Genome Wide Association ◽  
Common Variants ◽  
Genome Wide

scholarly journals Genome-Wide Association Study Meta-Analysis for Parkinson’s Disease Motor Subtypes

2020 ◽  
Author(s):  
Isabel Alfradique-Dunham ◽  
Rami Al-Ouran ◽  
Rainer von Coelln ◽  
Cornelis Blauwendraat ◽  
Emily Hill ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Association Study ◽  
Essential Tremor ◽  
Genetic Risk ◽  
Genome Wide Association Study ◽  
Meta Analysis ◽  
Genome Wide Association ◽  
Risk Variants ◽  
Genome Wide

AbstractOBJECTIVETo discover genetic determinants of Parkinson disease (PD) motor subtypes, including Tremor Dominant (TD) and Postural Instability/Gait Difficulty (PIGD) forms.METHODSIn 3,212 PD cases of European ancestry, we performed a genome-wide association study (GWAS) examining two complementary outcome traits derived from the Unified Parkinson’s Disease Rating Scale (UPDRS), including dichotomous motor subtype (TD vs. PIGD) or a continuous tremor / PIGD score ratio. Logistic or linear regression models were adjusted for sex, age of onset, disease duration, and 5 ancestry principal components, followed by meta-analysis.RESULTSAmong 71 established PD risk variants, we detected multiple suggestive associations with PD motor subtype, including GPNMB (rs199347, psubtype = 0.01, pratio = 0.03), SH3GL2 (rs10756907, psubtype = 0.02, pratio = 0.01), HIP1R (rs10847864, psubtype = 0.02), RIT2 (rs12456492, psubtype = 0.02), and FBRSL1 (rs11610045, psubtype = 0.02). A PD genetic risk score integrating all 71 PD risk variants was also associated with subtype ratio (p = 0.026, ß = −0.04, 95% CI = −0.07, 0). Based on top results of our GWAS, we identify a novel suggestive association at the STK32B locus (rs2301857, pratio = 6.6×10−7), which harbors an independent risk allele for essential tremor.CONCLUSIONSMultiple PD risk alleles may also modify clinical manifestations to influence PD motor subtype. The discovery of a novel variant at STK32B suggests a possible overlap between genetic risk for essential tremor and tremor-dominant PD.

Linking a genome-wide association study signal to aLRRK2coding variant in Parkinson's disease

2015 ◽  
Vol 31 (4) ◽  
pp. 484-487 ◽  
Author(s):  
Jia Nee Foo ◽  
Sun Ju Chung ◽  
Louis C. Tan ◽  
Herty Liany ◽  
Ho-Sung Ryu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals Web-Based Genome-Wide Association Study Identifies Two Novel Loci and a Substantial Genetic Component for Parkinson's Disease

PLoS Genetics ◽  
2011 ◽  
Vol 7 (6) ◽  
pp. e1002141 ◽  
Author(s):  
Chuong B. Do ◽  
Joyce Y. Tung ◽  
Elizabeth Dorfman ◽  
Amy K. Kiefer ◽  
Emily M. Drabant ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genetic Component ◽  
Genome Wide Association ◽  
Web Based ◽  
Genome Wide
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