Longitudinal study of the motor response to levodopa in Parkinson's disease

2006 ◽  
Vol 21 (12) ◽  
pp. 2116-2121 ◽  
Author(s):  
Benjamin G. Clissold ◽  
Craig D. McColl ◽  
Katrina R. Reardon ◽  
Mark Shiff ◽  
Peter A. Kempster
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Longitudinal Study ◽  
Motor Response

Longitudinal study of the levodopa motor response in Parkinson's disease: Relationship between cognitive decline and motor function

2009 ◽  
pp. NA-NA ◽  
Author(s):  
Jane E. Alty ◽  
Benjamin G. Clissold ◽  
Craig D. McColl ◽  
Katrina A. Reardon ◽  
Mark Shiff ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Longitudinal Study ◽  
Cognitive Decline ◽  
Motor Function ◽  
Motor Response

The duration of the motor response to apomorphine boluses is conditioned by the length of a prior infusion in Parkinson's disease

2009 ◽  
Vol 24 (5) ◽  
pp. 762-766 ◽  
Author(s):  
Julia Vaamonde ◽  
José M. Flores ◽  
Roberto Weisser ◽  
Ramón Ibañez ◽  
José A. Obeso
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Response

THUR 117 The L-DOPA response in pathologically confirmed parkinson’s disease

2018 ◽  
Vol 89 (10) ◽  
pp. A12.4-A13
Author(s):  
Vanessa Pitz ◽  
Naveed Malek ◽  
Katherine A Grosset ◽  
Donald G Grosset
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Response ◽  
Standard Treatment ◽  
Disease Onset ◽  
Lewy Body Disease ◽  
Amyloid Angiopathy ◽  
Brain Pathology ◽  
Diffuse Lewy Body Disease ◽  
Available Information

Backgroundl-dopa is the standard treatment for Parkinson’s disease, but the response is variable.AimSystematic review of papers reporting the l-dopa response (motor response and/or complications) in pathologically confirmed Parkinson’s disease.Results467 cases of pathologically confirmed Parkinson’s were identified: 60.2% male, age at disease onset 63.3 years (SD 10.3), age at death 76.7 years (SD 7.8). Data on a graded l-dopa response were available in 411 cases (88.0% of 467). The motor response was excellent in 148/411 cases (36.0%), good in 179/411 (43.6%), moderate in 51/411 (12.4%) and poor/absent in 33/411 (8.0%). Data about motor complications were available for 161 patients: 71/161 (44.1%) had motor fluctuations and 89/161 (55.3%) had dyskinesia. Comorbid brain pathology was evaluated in 251/411 cases (61.1%), and was present in 148/251 (59.0%): cerebrovascular in 65/148 (43.9%), Alzheimer’s in 55/148 (37.2%), amyloid angiopathy in 18/148 (12.2%), and diffuse Lewy body disease in 10/148 (6.8%). Data linking the graded l-dopa response to comorbid pathologies were available in only 17 cases, of whom 8/17 (47.1%) had a good/excellent response.ConclusionThere is variation in the l-dopa response in pathologically confirmed Parkinson’s disease. The limited available information suggests a possible association of motor response to comorbid brain pathology.

scholarly journals Writers Are Common among Parkinson’s Disease Patients: A Longitudinal Study

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Anna Aasly ◽  
Jan O. Aasly
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Longitudinal Study ◽  
General Population ◽  
Personality Disorders ◽  
Disease Progression ◽  
Medical Record ◽  
Disease Onset ◽  
Psychological Characteristics ◽  
Personality Profile

Parkinson’s disease (PD) patients may have a specific personality profile, which includes being introvert, cautious and devoted to hard work. The evaluation of psychological characteristics must be evaluated according to methods for assessments of personality disorders. Such evaluations are often time-consuming and available only in research settings. The “parkinsonian trait” may be established early in life but may change with disease progression. To overcome this long interval before onset of PD questions on literary activities were included in the medical record. Three percent of PD patients could be defined as writers, significantly higher than observed in the general population. PD writers published their first books long before onset of disease. Being a writer is an extrovert trait meaning that the patient is prepared for criticism and publicity. We suggest that questions regarding personal activities prior to disease onset add valuable information on personality which differs significantly from traits observed later in the disease period.

Motor response to levodopa and the evolution of motor fluctuations in the first decade of treatment of Parkinson's disease

2002 ◽  
Vol 17 (6) ◽  
pp. 1227-1234 ◽  
Author(s):  
Craig D. McColl ◽  
Katrina A. Reardon ◽  
Mark Shiff ◽  
Peter A. Kempster
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Response ◽  
Motor Fluctuations

Examining the Reserve Hypothesis in Parkinson's Disease: A Longitudinal Study

2019 ◽  
Vol 34 (11) ◽  
pp. 1663-1671 ◽  
Author(s):  
Pei‐Chen Lee ◽  
Fanny Artaud ◽  
Florence Cormier‐Dequaire ◽  
Olivier Rascol ◽  
Franck Durif ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Longitudinal Study
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