scholarly journals Pilot Study of the International Parkinson and Movement Disorder Society‐sponsored Non‐motor Rating Scale (MDS‐NMS)

2019 ◽  
Vol 6 (3) ◽  
pp. 227-234 ◽  
Author(s):  
Pablo Martinez‐Martin ◽  
Anette Schrag ◽  
Daniel Weintraub ◽  
Alexandra Rizos ◽  
Carmen Rodriguez‐Blazquez ◽  
...  
Keyword(s):  
Pilot Study ◽  
Movement Disorder ◽  
Rating Scale ◽  
Movement Disorder Society

scholarly journals Randomized double-blind placebo-controlled trial of hydrogen inhalation for Parkinson’s disease: a pilot study

2021 ◽  
Author(s):  
Asako Yoritaka ◽  
Yasuko Kobayashi ◽  
Tetsuo Hayashi ◽  
Shinji Saiki ◽  
Nobutaka Hattori
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Pilot Study ◽  
Movement Disorder ◽  
Molecular Hydrogen ◽  
Rating Scale ◽  
Total Duration ◽  
Hydrogen Gas ◽  
Double Blind ◽  
Movement Disorder Society

Abstract Background Oxidative stress is involved in the progression of Parkinson’s disease (PD). Recent studies have confirmed that molecular hydrogen (H2) functions as a highly effective antioxidant in animal models of PD. A placebo-controlled, randomized, double-blind, parallel-group clinical pilot study was conducted to assess the efficacy of hydrogen gas inhalation in Japanese patients with PD on treatment with levodopa. Methods Twenty participants fulfilling the Movement Disorder Society criteria were enrolled. Participants inhaled 6.5 (0.1) vol% hydrogen gas in 2 L/min of mixed air or placebo air for 16 weeks, twice a day for 1 h. Results Five participants were excluded due to deviation from the protocol of the total duration of inhalation < 112 h. No significant differences were seen in the change in the total Movement Disorder Society Unified Parkinson’s Disease Rating Scale score from baseline to the 16th week between the group that inhaled hydrogen gas and the group that inhaled placebo air (Mann–Whitney U test, p > 0.05). No adverse events were seen. The compliance to the protocol-based duration of inhalation time in all participants decreased with the elderly participants, the higher daily dose of levodopa, and the higher PDQ-39 items on emotions (n = 20, p < 0.05). Conclusion This pilot study revealed that the inhalation of molecular hydrogen gas was safe, but did not show any beneficial effects in patients with PD. Trial registration: UMIN ID: 000,039,217 (October 6, 2018)

scholarly journals Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Process, format, and clinimetric testing plan

2007 ◽  
Vol 22 (1) ◽  
pp. 41-47 ◽  
Author(s):  
Christopher G. Goetz ◽  
Stanley Fahn ◽  
Pablo Martinez-Martin ◽  
Werner Poewe ◽  
Cristina Sampaio ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Movement Disorder ◽  
Rating Scale ◽  
Disease Rating ◽  
Testing Plan ◽  
Movement Disorder Society

Factor Analysis and Clustering of the Movement Disorder Society–Non‐Motor Rating Scale

2020 ◽  
Vol 35 (6) ◽  
pp. 969-975
Author(s):  
Pablo Martinez‐Martin ◽  
Jose Manuel Rojo‐Abuín ◽  
Daniel Weintraub ◽  
Kallol Ray Chaudhuri ◽  
Carmen Rodriguez‐Blázquez ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Movement Disorder ◽  
Rating Scale ◽  
Movement Disorder Society

scholarly journals Relación entre los síntomas musculoesqueléticos y la funcionalidad en personas con enfermedad de Parkinson

2018 ◽  
Vol 5 (2) ◽  
pp. 14
Author(s):  
Araceli Ortiz-Rubio ◽  
Irene Cabrera-Martos ◽  
Irene Torres-Sánchez ◽  
Laura López-López ◽  
Janet Rodríguez-Torres ◽  
...  
Keyword(s):  
Physical Activity ◽  
Movement Disorder ◽  
Rating Scale ◽  
Frailty Index ◽  
Brief Pain Inventory ◽  
Severity Scale ◽  
Disease Rating ◽  
Fatigue Severity ◽  
Ability Measure ◽  
Movement Disorder Society

Introducción: La enfermedad de Parkinson (EP) es una de las enfermedades más frecuentes del sistema nervioso central, y además de los síntomas motores clásicos, ahora se sabe que los pacientes también sufren una variedad de síntomas no motores que afectan negativamente a la independencia funcional. Objetivo: El objetivo de este estudio fue evaluar la relación entre los síntomas musculoesqueléticos y la funcionalilidad en personas con EP. Materiales y Métodos: Este estudio es un estudio observacional transversal que involucra a pacientes con enfermedad de Parkinson utilizando los siguientes instrumentos: Movement Disorder Society-Unified Parkinson’s Disease Rating Scale (MDS- UPDRS), Fahn-Tolosa-Marín Tremor Rating Scale (TRS), Manual Ability Measure-16 (MAM-16), Evaluative Frailty Index for Physical Activity (EFIP), Coin Rotation Task (CRT), Fatigue Severity Scale (FSS), Brief Pain Inventory (BPI). Resultados: Se incluyeron 24 pacientes, con una edad media de 72,54 ± 9,4 años.  Se encontró relación (p < 0,05) entre las variables severidad del Parkinson, temblor, destreza, fatiga y dolor con las variables de funcionalidad. Conclusiones: Puntuaciones altas en las afecciones musculoesqueléticas se asocian con discapacidad. El enfoque de la gestión en la EP debe cambiar a una estrategia integral que incorpore el cuidado de síntomas motores como el temblor o la destreza y síntomas no motores como la fatiga y el dolor.

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