scholarly journals Metal transporter Slc30a1 controls pharyngeal neural crest differentiation via the zinc‐Snai2‐Jag1 cascade

MedComm ◽  
2021 ◽  
Author(s):  
Zhidan Xia ◽  
Xinying Bi ◽  
Sisi Yang ◽  
Xiu Yang ◽  
Zijun Song ◽  
...  
Keyword(s):  
Neural Crest ◽  
Metal Transporter ◽  
Neural Crest Differentiation

BRD4 orchestrates genome folding to promote neural crest differentiation

2021 ◽  
Vol 53 (10) ◽  
pp. 1480-1492
Author(s):  
Ricardo Linares-Saldana ◽  
Wonho Kim ◽  
Nikhita A. Bolar ◽  
Haoyue Zhang ◽  
Bailey A. Koch-Bojalad ◽  
...  
Keyword(s):  
Neural Crest ◽  
Neural Crest Differentiation

scholarly journals A new transgenic reporter line reveals Wnt-dependent Snai2 re-expression and cranial neural crest differentiation in Xenopus

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Jiejing Li ◽  
Mark Perfetto ◽  
Christopher Materna ◽  
Rebecca Li ◽  
Hong Thi Tran ◽  
...  
Keyword(s):  
Neural Crest ◽  
Cranial Neural Crest ◽  
Reporter Line ◽  
Neural Crest Differentiation

scholarly journals New genes in the evolution of the neural crest differentiation program

2007 ◽  
Vol 8 (3) ◽  
pp. R36 ◽  
Author(s):  
Juan-Ramon Martinez-Morales ◽  
Thorsten Henrich ◽  
Mirana Ramialison ◽  
Joachim Wittbrodt ◽  
Juan-Ramon Martinez-Morales
Keyword(s):  
Neural Crest ◽  
New Genes ◽  
Neural Crest Differentiation

BMP signaling initiates a neural crest differentiation program in embryonic rat CNS stem cells

2004 ◽  
Vol 188 (2) ◽  
pp. 205-223 ◽  
Author(s):  
Shyam Gajavelli ◽  
Patrick M. Wood ◽  
Diane Pennica ◽  
Scott R. Whittemore ◽  
Pantelis Tsoulfas
Keyword(s):  
Stem Cells ◽  
Neural Crest ◽  
Bmp Signaling ◽  
Neural Crest Differentiation ◽  
Rat Cns

scholarly journals Amphioxus and lamprey AP-2 genes: implications for neural crest evolution and migration patterns

Development ◽  
2002 ◽  
Vol 129 (21) ◽  
pp. 4953-4962 ◽  
Author(s):  
Daniel Meulemans ◽  
Marianne Bronner-Fraser
Keyword(s):  
Neural Crest ◽  
Neural Tube ◽  
Neural Crest Cells ◽  
Vertebrate Evolution ◽  
Cranial Neural Crest ◽  
Vertebrate Lineage ◽  
Evolutionary Transitions ◽  
And Migration ◽  
Differentiation And Proliferation ◽  
Neural Crest Differentiation

The neural crest is a uniquely vertebrate cell type present in the most basal vertebrates, but not in cephalochordates. We have studied differences in regulation of the neural crest marker AP-2 across two evolutionary transitions: invertebrate to vertebrate, and agnathan to gnathostome. Isolation and comparison of amphioxus, lamprey and axolotl AP-2 reveals its extensive expansion in the vertebrate dorsal neural tube and pharyngeal arches, implying co-option of AP-2 genes by neural crest cells early in vertebrate evolution. Expression in non-neural ectoderm is a conserved feature in amphioxus and vertebrates, suggesting an ancient role for AP-2 genes in this tissue. There is also common expression in subsets of ventrolateral neurons in the anterior neural tube, consistent with a primitive role in brain development. Comparison of AP-2 expression in axolotl and lamprey suggests an elaboration of cranial neural crest patterning in gnathostomes. However,migration of AP-2-expressing neural crest cells medial to the pharyngeal arch mesoderm appears to be a primitive feature retained in all vertebrates. Because AP-2 has essential roles in cranial neural crest differentiation and proliferation, the co-option of AP-2 by neural crest cells in the vertebrate lineage was a potentially crucial event in vertebrate evolution.

scholarly journals TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation

2020 ◽  
Author(s):  
Xiaochen Fan ◽  
V. Pragathi Masamsetti ◽  
Jane Q. J. Sun ◽  
Kasper Engholm-Keller ◽  
Pierre Osteil ◽  
...  
Keyword(s):  
Neural Crest ◽  
Cell Fate ◽  
Neural Crest Cell ◽  
Genetic Circuit ◽  
Cellular Functions ◽  
Chromatin Regulators ◽  
Regulatory Module ◽  
Network Propagation ◽  
Neural Crest Differentiation ◽  
Crest Cell

AbstractProtein interaction is critical molecular regulatory activity underlining cellular functions and precise cell fate choices. Using TWIST1 BioID-proximity-labelling and network propagation analyses, we discovered and characterized a TWIST-chromatin regulatory module (TWIST1-CRM) in the neural crest cell (NCC). Combinatorial perturbation of core members of TWIST1-CRM: TWIST1, CHD7, CHD8, and WHSC1 in cell models and mouse embryos revealed that loss of the function of the regulatory module resulted in abnormal specification of NCCs and compromised craniofacial tissue patterning. Our results showed that in the course of cranial neural crest differentiation, phasic activity of TWIST1 and the interacting chromatin regulators promote the choice of NCC fate while suppressing neural stem cell fates, and subsequently enhance ectomesenchyme potential and cell motility. We have revealed the connections between TWIST1 and potential neurocristopathy factors which are functionally interdependent in NCC specification. Moreover, the NCC module participate in the genetic circuit delineating dorsal-ventral patterning of neural progenitors in the neuroepithelium.

scholarly journals Publisher Correction: BRD4 orchestrates genome folding to promote neural crest differentiation

2021 ◽  
Author(s):  
Ricardo Linares-Saldana ◽  
Wonho Kim ◽  
Nikhita A. Bolar ◽  
Haoyue Zhang ◽  
Bailey A. Koch-Bojalad ◽  
...  
Keyword(s):  
Neural Crest ◽  
Neural Crest Differentiation
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