scholarly journals Novel cell sources for bone regeneration

MedComm ◽  
2021 ◽  
Author(s):  
Chenshuang Li ◽  
Zane Mills ◽  
Zhong Zheng
Keyword(s):  
Bone Regeneration ◽  
Cell Sources

scholarly journals Stem Cells for Bone Regeneration: From Cell-Based Therapies to Decellularised Engineered Extracellular Matrices

2016 ◽  
Vol 2016 ◽  
pp. 1-15 ◽  
Author(s):  
James N. Fisher ◽  
Giuseppe M. Peretti ◽  
Celeste Scotti
Keyword(s):  
Tissue Engineering ◽  
Bone Marrow ◽  
Bone Regeneration ◽  
Bone Growth ◽  
Long Bone ◽  
Advantages And Disadvantages ◽  
Naturally Occurring ◽  
Cell Sources ◽  
Alternative Techniques ◽  
Developmental Engineering

Currently, autologous bone grafting represents the clinical gold standard in orthopaedic surgery. In certain cases, however, alternative techniques are required. The clinical utility of stem and stromal cells has been demonstrated for the repair and regeneration of craniomaxillofacial and long bone defects although clinical adoption of bone tissue engineering protocols has been very limited. Initial tissue engineering studies focused on the bone marrow as a source of cells for bone regeneration, and while a number of promising results continue to emerge, limitations to this technique have prompted the exploration of alternative cell sources, including adipose and muscle tissue. In this review paper we discuss the advantages and disadvantages of cell sources with a focus on adipose tissue and the bone marrow. Additionally, we highlight the relatively recent paradigm of developmental engineering, which promotes the recapitulation of naturally occurring developmental processes to allow the implant to optimally respond to endogenous cues. Finally we examine efforts to apply lessons from studies into different cell sources and developmental approaches to stimulate bone growth by use of decellularised hypertrophic cartilage templates.

scholarly journals Advances on Bone Substitutes through 3D Bioprinting

2020 ◽  
Vol 21 (19) ◽  
pp. 7012 ◽  
Author(s):  
Tullio Genova ◽  
Ilaria Roato ◽  
Massimo Carossa ◽  
Chiara Motta ◽  
Davide Cavagnetto ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
New Technologies ◽  
Treatment Options ◽  
Three Dimensional ◽  
Bone Substitutes ◽  
Biological Properties ◽  
3D Bioprinting ◽  
Cell Sources ◽  
Biological Cost ◽  
Living Tissues

Reconstruction of bony defects is challenging when conventional grafting methods are used because of their intrinsic limitations (biological cost and/or biological properties). Bone regeneration techniques are rapidly evolving since the introduction of three-dimensional (3D) bioprinting. Bone tissue engineering is a branch of regenerative medicine that aims to find new solutions to treat bone defects, which can be repaired by 3D printed living tissues. Its aim is to overcome the limitations of conventional treatment options by improving osteoinduction and osteoconduction. Several techniques of bone bioprinting have been developed: inkjet, extrusion, and light-based 3D printers are nowadays available. Bioinks, i.e., the printing materials, also presented an evolution over the years. It seems that these new technologies might be extremely promising for bone regeneration. The purpose of the present review is to give a comprehensive summary of the past, the present, and future developments of bone bioprinting and bioinks, focusing the attention on crucial aspects of bone bioprinting such as selecting cell sources and attaining a viable vascularization within the newly printed bone. The main bioprinters currently available on the market and their characteristics have been taken into consideration, as well.

Decellularized bone extracellular matrix in skeletal tissue engineering

2020 ◽  
Vol 48 (3) ◽  
pp. 755-764
Author(s):  
Benjamin B. Rothrauff ◽  
Rocky S. Tuan
Keyword(s):  
Tissue Engineering ◽  
Bone Regeneration ◽  
Tissue Regeneration ◽  
Animal Studies ◽  
Tumor Resection ◽  
Regenerative Capacity ◽  
Skeletal Tissue ◽  
Large Bone

Bone possesses an intrinsic regenerative capacity, which can be compromised by aging, disease, trauma, and iatrogenesis (e.g. tumor resection, pharmacological). At present, autografts and allografts are the principal biological treatments available to replace large bone segments, but both entail several limitations that reduce wider use and consistent success. The use of decellularized extracellular matrices (ECM), often derived from xenogeneic sources, has been shown to favorably influence the immune response to injury and promote site-appropriate tissue regeneration. Decellularized bone ECM (dbECM), utilized in several forms — whole organ, particles, hydrogels — has shown promise in both in vitro and in vivo animal studies to promote osteogenic differentiation of stem/progenitor cells and enhance bone regeneration. However, dbECM has yet to be investigated in clinical studies, which are needed to determine the relative efficacy of this emerging biomaterial as compared with established treatments. This mini-review highlights the recent exploration of dbECM as a biomaterial for skeletal tissue engineering and considers modifications on its future use to more consistently promote bone regeneration.

Placenta mesenchymal stem cells on a chorion scaffold as a potential osteogenic graft for peripartal bone regeneration

2008 ◽  
Vol 68 (S 01) ◽  
Author(s):  
S Mohr ◽  
BC Portmann-Lanz ◽  
A Schoeberlein ◽  
R Sager ◽  
DV Surbek
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Regeneration

Combination of novel two-photon photopolymerised scaffolds and bioactive elastin-like-recombinamers induce bone regeneration

2016 ◽  
Author(s):  
Carina Kampleitner ◽  
Gerhard Hildebrand ◽  
Klaus Liefeith ◽  
Constancio Gonzalez ◽  
Jose Carlos Rodriguez-Cabello ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Two Photon

SauFRa technique for the fixation of resorbable membranes in horizontal guided bone regeneration - a technical report

2020 ◽  
Author(s):  
Saurabh Mohan Kamat ◽  
Rakshit Khandeparker ◽  
Francis Akkara ◽  
Vikas Dhupar ◽  
Ashwin Mysore
Keyword(s):  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Novel Technique ◽  
Technical Report ◽  
Suturing Techniques ◽  
Graft Migration

Membrane fixation in guided bone regeneration (GBR) has been traditionally achieved using resorbable pins, titanium tacks or miniscrews. However, these techniques are marredwith a number of clinical challenges. This article presents the “SauFRa” technique, a novel technique for stabilization of resorbable membranes in both, single as well as multiple implant sites while avoiding the shortcomings of other suturing techniques described in literature. Furthermore, the technique also eliminates the possibility of complications observed when using resorbable pins, titanium tacks or miniscrews, such as damage to adjacent roots during insertion. The authors’ employed this technique in 89 patients (51 male and 35 female) and found no complications like tissue dehiscence, infection or graft migration.

C and CX3C Chemokines: Cell Sources and Physiopathological Implications

2004 ◽  
Vol 24 (3) ◽  
pp. 205-288 ◽  
Author(s):  
Laura Stievano ◽  
Erich Piovan ◽  
Alberto Amadori
Keyword(s):  
Cell Sources
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