Alterations in the methylation status and expression of theraf oncogene in phenobarbital-induced and spontaneous B6C3F1 mouse liver tumors

1994 ◽  
Vol 9 (3) ◽  
pp. 155-166 ◽  
Author(s):  
Jean S. Ray ◽  
Margaret L. Harbison ◽  
R. Michael McClain ◽  
Jay I. Goodman
Keyword(s):  
Mouse Liver ◽  
Liver Tumors ◽  
Methylation Status ◽  
B6c3f1 Mouse

Activated oncogenes in B6C3F1 mouse liver tumors: implications for risk assessment

Science ◽  
1987 ◽  
Vol 237 (4820) ◽  
pp. 1309-1316 ◽  
Author(s):  
S. Reynolds ◽  
S. Stowers ◽  
R. Patterson ◽  
R. Maronpot ◽  
S. Aaronson ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Mouse Liver ◽  
Liver Tumors ◽  
B6c3f1 Mouse

scholarly journals Activation of H-ras oncogenes in male B6C3F1 mouse liver tumors induced by vinthionine or 2-chloroethyl methyl sulfide

1996 ◽  
Vol 17 (6) ◽  
pp. 1361-1364 ◽  
Author(s):  
Yeo-Won Sohn ◽  
Gang-Hong Lee ◽  
Amy Liem ◽  
James A. Miller
Keyword(s):  
Mouse Liver ◽  
Liver Tumors ◽  
Methyl Sulfide ◽  
B6c3f1 Mouse ◽  
Ras Oncogenes

Analysis of activated protooncogenes in B6C3F1 mouse liver tumors induced by ciprofibrate, a potent peroxisome proliferator

1993 ◽  
Vol 14 (1) ◽  
pp. 145-149 ◽  
Author(s):  
Monika E. Hegi ◽  
Tony R. Fox ◽  
Steven A. Belinsky ◽  
Theodora R. Devereux ◽  
Marshall W. Anderson
Keyword(s):  
Mouse Liver ◽  
Liver Tumors ◽  
Peroxisome Proliferator ◽  
B6c3f1 Mouse

p53 mutations are absent from carcinogen-induced mouse liver tumors but occur in cell lines established from these tumors

1992 ◽  
Vol 6 (2) ◽  
pp. 148-158 ◽  
Author(s):  
Stefan Kress ◽  
Jorg König ◽  
Jürgen Schweizer ◽  
Heinz Löhrke ◽  
Richard Bauer-Hofmann ◽  
...  
Keyword(s):  
Cell Lines ◽  
Mouse Liver ◽  
Liver Tumors ◽  
P53 Mutations

scholarly journals Growth hormone upregulates the pro-tumorigenic galectin 1 in mouse liver

2019 ◽  
Vol 8 (8) ◽  
pp. 1108-1117 ◽  
Author(s):  
María L Bacigalupo ◽  
Verónica G Piazza ◽  
Nadia S Cicconi ◽  
Pablo Carabias ◽  
Andrzej Bartke ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Transgenic Mice ◽  
Mouse Liver ◽  
Liver Tumors ◽  
Tumor Development ◽  
Hepatic Cancer ◽  
Liver Pathology ◽  
Liver Carcinogenesis ◽  
Short Period ◽  
Hcc Cells

Transgenic mice overexpressing growth hormone (GH) spontaneously develop liver tumors, including hepatocellular carcinoma (HCC), within a year. The preneoplastic liver pathology in these mice recapitulates that observed in humans at high risk of developing hepatic cancer. Although increased expression of galectin 1 (GAL1) in liver tissue is associated with HCC aggressiveness, a link between this glycan-binding protein and hormone-related tumor development has not yet been explored. In this study, we investigated GAL1 expression during liver tumor progression in mice continuously exposed to high levels of GH. GAL1 expression was determined by Western blotting, RT-qPCR and immunohistochemistry in the liver of transgenic mice overexpressing GH. Animals of representative ages at different stages of liver pathology were studied. GAL1 expression was upregulated in the liver of GH-transgenic mice. This effect was observed at early ages, when animals displayed no signs of liver disease or minimal histopathological alterations and was also detected in young adults with preneoplastic liver pathology. Remarkably, GAL1 upregulation was sustained during aging and its expression was particularly enhanced in liver tumors. GH also induced hepatic GAL1 expression in mice that were treated with this hormone for a short period. Moreover, GH triggered a rapid increment in GAL1 protein expression in human HCC cells, denoting a direct effect of the hormone on hepatocytes. Therefore, our results indicate that GH upregulates GAL1 expression in mouse liver, which may have critical implications in tumorigenesis. These findings suggest that this lectin could be implicated in hormone-driven liver carcinogenesis.

scholarly journals Oncogenic Determination of a Broad Spectrum of Phenotypes of Hepatocyte-Derived Mouse Liver Tumors

2017 ◽  
Vol 187 (12) ◽  
pp. 2711-2725 ◽  
Author(s):  
Masahiro Yamamoto ◽  
Bing Xin ◽  
Kenji Watanabe ◽  
Takako Ooshio ◽  
Kiyonaga Fujii ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Mouse Liver ◽  
Liver Tumors
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