scholarly journals Oncogenic Determination of a Broad Spectrum of Phenotypes of Hepatocyte-Derived Mouse Liver Tumors

2017 ◽  
Vol 187 (12) ◽  
pp. 2711-2725 ◽  
Author(s):  
Masahiro Yamamoto ◽  
Bing Xin ◽  
Kenji Watanabe ◽  
Takako Ooshio ◽  
Kiyonaga Fujii ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Mouse Liver ◽  
Liver Tumors

p53 mutations are absent from carcinogen-induced mouse liver tumors but occur in cell lines established from these tumors

1992 ◽  
Vol 6 (2) ◽  
pp. 148-158 ◽  
Author(s):  
Stefan Kress ◽  
Jorg König ◽  
Jürgen Schweizer ◽  
Heinz Löhrke ◽  
Richard Bauer-Hofmann ◽  
...  
Keyword(s):  
Cell Lines ◽  
Mouse Liver ◽  
Liver Tumors ◽  
P53 Mutations

Determination of 5-phosphoribosyl 1-pyrophosphate in mouse liver

1974 ◽  
Vol 62 (1) ◽  
pp. 121-133 ◽  
Author(s):  
Marcel Lalanne ◽  
J.Frank Henderson
Keyword(s):  
Mouse Liver

scholarly journals The Diagnostic Value of Cytokeratin 7 and 20 in Determination of Primary and Metastatic Liver Tumors

2015 ◽  
Vol 25 (1) ◽  
Author(s):  
Deniz Nart ◽  
Banu Yaman ◽  
Serap Karaarslan ◽  
Murat Zeytunlu ◽  
Murat Kilic ◽  
...  
Keyword(s):  
Liver Tumors ◽  
Diagnostic Value ◽  
Cytokeratin 7 ◽  
Metastatic Liver Tumors ◽  
Metastatic Liver

scholarly journals Growth hormone upregulates the pro-tumorigenic galectin 1 in mouse liver

2019 ◽  
Vol 8 (8) ◽  
pp. 1108-1117 ◽  
Author(s):  
María L Bacigalupo ◽  
Verónica G Piazza ◽  
Nadia S Cicconi ◽  
Pablo Carabias ◽  
Andrzej Bartke ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Transgenic Mice ◽  
Mouse Liver ◽  
Liver Tumors ◽  
Tumor Development ◽  
Hepatic Cancer ◽  
Liver Pathology ◽  
Liver Carcinogenesis ◽  
Short Period ◽  
Hcc Cells

Transgenic mice overexpressing growth hormone (GH) spontaneously develop liver tumors, including hepatocellular carcinoma (HCC), within a year. The preneoplastic liver pathology in these mice recapitulates that observed in humans at high risk of developing hepatic cancer. Although increased expression of galectin 1 (GAL1) in liver tissue is associated with HCC aggressiveness, a link between this glycan-binding protein and hormone-related tumor development has not yet been explored. In this study, we investigated GAL1 expression during liver tumor progression in mice continuously exposed to high levels of GH. GAL1 expression was determined by Western blotting, RT-qPCR and immunohistochemistry in the liver of transgenic mice overexpressing GH. Animals of representative ages at different stages of liver pathology were studied. GAL1 expression was upregulated in the liver of GH-transgenic mice. This effect was observed at early ages, when animals displayed no signs of liver disease or minimal histopathological alterations and was also detected in young adults with preneoplastic liver pathology. Remarkably, GAL1 upregulation was sustained during aging and its expression was particularly enhanced in liver tumors. GH also induced hepatic GAL1 expression in mice that were treated with this hormone for a short period. Moreover, GH triggered a rapid increment in GAL1 protein expression in human HCC cells, denoting a direct effect of the hormone on hepatocytes. Therefore, our results indicate that GH upregulates GAL1 expression in mouse liver, which may have critical implications in tumorigenesis. These findings suggest that this lectin could be implicated in hormone-driven liver carcinogenesis.

Flow-suppressed hyperpolarized 13 C chemical shift imaging using velocity-optimized bipolar gradient in mouse liver tumors at 9.4 T

2016 ◽  
Vol 78 (5) ◽  
pp. 1674-1682 ◽  
Author(s):  
Hansol Lee ◽  
Joonsung Lee ◽  
Eunhae Joe ◽  
Seungwook Yang ◽  
Jae Eun Song ◽  
...  
Keyword(s):  
Chemical Shift ◽  
Mouse Liver ◽  
Liver Tumors ◽  
Chemical Shift Imaging
Sign in / Sign up

Export Citation Format

Share Document