Normal human chromosome 11 suppresses tumorigenicity of human cervical tumor cell line SiHa

1989 ◽  
Vol 2 (1) ◽  
pp. 12-21 ◽  
Author(s):  
Minoru Koi ◽  
Hiroyuki Morita ◽  
Hideto Yamada ◽  
Hitoshi Satoh ◽  
J. Carl Barrett ◽  
...  
Science ◽  
1987 ◽  
Vol 236 (4798) ◽  
pp. 175-180 ◽  
Author(s):  
B. Weissman ◽  
P. Saxon ◽  
Pasquale ◽  
G. Jones ◽  
A. Geiser ◽  
...  

1995 ◽  
Vol 13 (4) ◽  
pp. 220-232 ◽  
Author(s):  
William B. Coleman ◽  
Karen D. McCullough ◽  
Gwyn L. Esch ◽  
Chris J. Civalier ◽  
Elizabeth Livanos ◽  
...  

2003 ◽  
Vol 79 (1) ◽  
pp. 151-157 ◽  
Author(s):  
Akiko Fujii ◽  
Tasuku Harada ◽  
Nobuhiro Yamauchi ◽  
Tomio Iwabe ◽  
Yoshihiro Nishi ◽  
...  

Science ◽  
1991 ◽  
Vol 254 (5029) ◽  
pp. 293-295
Author(s):  
SF Dowdy ◽  
CL Fasching ◽  
D Araujo ◽  
KM Lai ◽  
E Livanos ◽  
...  

Wilms tumor has been associated with genomic alterations at both the 11p13 and 11p15 regions. To differentiate between the involvement of these two loci, a chromosome 11 was constructed that had one or the other region deleted, and this chromosome was introduced into the tumorigenic Wilms tumor cell line G401. When assayed for tumor-forming activity in nude mice, the 11p13-deleted, but not the 11p15.5-p14.1-deleted chromosome, retained its ability to suppress tumor formation. These results provide in vivo functional evidence for the existence of a second genetic locus (WT2) involved in suppressing the tumorigenic phenotype of Wilms tumor.


1990 ◽  
Vol 42 (3) ◽  
pp. 135-142 ◽  
Author(s):  
Mitsuo Oshimura ◽  
Hiroyuki Kugoh ◽  
Minoru Koi ◽  
Motoyuki Shimizu ◽  
Hideto Yamada ◽  
...  

1983 ◽  
Vol 48 (2) ◽  
pp. 377-383 ◽  
Author(s):  
E Knust ◽  
W Dietrich ◽  
B Fleckenstein ◽  
W Bodemer

2019 ◽  
Vol 26 (09) ◽  
pp. 1950058
Author(s):  
SADEQ H. LAFTA ◽  
ALI ABDULRAHMAN TAHA ◽  
MUHAMMAD M. FARHAN ◽  
SHAIMA Y. ABDULFATTAH

Nanoparticles of alpha ferric oxide ([Formula: see text]-Fe2O3) were prepared by the hydrothermal method. Structural properties of [Formula: see text]-Fe2O3 were determined by XRD, SEM and AFM measurements. The particles had a good matching with standard pattern. Average particle size was about 90[Formula: see text]nm and the distribution extended from about 20[Formula: see text]nm to 120[Formula: see text]nm. Biocompatibility study of ferric oxide nanoparticles against bacteria, parasites, tumor cell line and normal cells was determined. No antibacterial activity was observed for the concentration, of ferric oxide nanoparticles in distilled water, up to 1.5[Formula: see text]mg/ml vs. E. coli and S. aureus. Moreover, MTT assay was used to determine the cytotoxicity against parasites and cells. Intermediate cytotoxicity (53.30%) of 1.5[Formula: see text]mg/ml of prepared nanoparticles was noted against L. tropica, while weak cytotoxicity of 5.20% was observed against L. donovani at the same concentration of ferric oxide nanoparticles. On the other hand, the prepared nanoparticles revealed low cytotoxicity (47.28%) against SR tumor cell line, while no cytotoxicity was shown against lymphocytes, as a model of normal cells.


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